Chemotherapy-related fever or infection fever?

Eroğlu, Nilgün; Erduran, Erol; Reis, Gökçe Pınar; Bahadır, Ayşenur

doi:10.1007/s00520-020-05670-z

Cited by 4 publications

(2 citation statements)

References 13 publications

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“… 15 All patients were given prophylactic sulfamethoxazole against Pneumocystis jirovecii infection during chemotherapy. The differential diagnosis for causes of fever among infection, drug, and neoplasm was made based on the review of traditional microbial detection methods, mNGS, laboratory tests, medical imaging, response to empirical antibiotic treatment, the possibility of febrile coincides with drugs that were frequently associated with fever (eg, large dose of cytarabine), 16 and the exclusion of other causes of fever in the patient. 17 The diagnosis was made by two investigators (YF and XZ) and discrepancies resolved by discussion with a third reviewer (HW).…”

Section: Methodsmentioning

confidence: 99%

Metagenomic Next-Generation Sequencing in the Diagnosis of Infectious Fever During Myelosuppression Among Pediatric Patients with Hematological and Neoplastic Diseases

Fu¹,

Zhu²,

Cao³

et al. 2022

IDR

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Purpose To analyze the contribution of metagenomic next-generation sequencing (mNGS) in the guidance of clinical treatment and outcomes of infection during myelosuppression among children with hematological and neoplastic diseases. Patients and Methods The clinical data and results of mNGS assay of febrile patients suspected of infection were retrospectively collected. The characteristics of pathogenic microorganisms and clinical course of myelosuppressed children with hematological diseases were summarized. Results Our study included 70 patients (45 males) with a median age of 5 years (range: 0.5 to 13 y). During the study period, there were 96 events of suspected infection. According to comprehensive clinical diagnosis, 73 blood infections, 43 pneumonia and 2 urinary tract infections occurred. The positive rate of mNGS was significantly higher than that of traditional microbial detection (83.3% vs 17.7%). The main pathogens detected by mNGS were Pseudomonas aeruginosa, Acinetobacter , human herpesvirus, Candida and Aspergillus . The average duration of fever was 4.9 days and 11.6 days ( P < 0.05), and the average cost of anti-infection treatment was RMB ¥28,077 and 39,898 ( P < 0.05) among children received mNGS within 48 hours and more than 48 hours after the onset of infection symptoms. Conclusion mNGS contributes to clinical management of children with infection during myelosuppression, especially among patients with negative traditional microbial detection. Early implementation of mNGS in children with symptoms has a tendency to reduce the time of infection, fever and the cost of treatment.

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Section: Methodsmentioning

confidence: 99%

Metagenomic Next-Generation Sequencing in the Diagnosis of Infectious Fever During Myelosuppression Among Pediatric Patients with Hematological and Neoplastic Diseases

Fu¹,

Zhu²,

Cao³

et al. 2022

IDR

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“…[15] In this context, paracetamol, also known as acetaminophen, is an effective antipyretic and analgesic at therapeutic dosage. It can inhibit cell proliferation, [16,17] cause programmed cell death, [18,19] and alleviate pain and fever related to cisplatin chemotherapy, [20] as well as promote a cytotoxic effect of cisplatin on the liver [21] and ovarian cancer [22] via glutathione reduction and oxidative stress induction. These cytotoxic effects of paracetamol are due to its ability to transform itself into the reactive metabolite N-acetyl-p-benzoquinone imine by cytochrome P450 family.…”

mentioning

confidence: 99%

New paracetamol hybrids as anticancer and COX‐2 inhibitors: Synthesis, biological evaluation and docking studies

Alam,

Alsenani,

Abdelhamid

et al. 2023

Archiv der Pharmazie

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Drug repurposing is an emerging field in drug development that has provided many successful drugs. In the current study, paracetamol, a known antipyretic and analgesic agent, was chemically modified to generate paracetamol derivatives as anticancer and anticyclooxygenase‐2 (COX‐2) agents. Compound 11 bearing a fluoro group was the best cytotoxic candidate with half‐maximal inhibitory concentration (IC50) values ranging from 1.51 to 6.31 μM and anti‐COX‐2 activity with IC50 = 0.29 μM, compared to the standard drugs, doxorubicin and celecoxib. The cell cycle and apoptosis studies revealed that compound 11 possesses the ability to induce cell cycle arrest in the S phase and apoptosis in colon Huh‐7 cells. These results were strongly supported by docking studies, which showed strong interactions with the amino acids of the COX‐2 protein, and in silico pharmacokinetic predictions were found to be favorable for these newly synthesized paracetamol derivatives. It can be concluded that compound 11 could block cell growth and proliferation by inhibiting the COX‐2 enzyme in cancer therapy.

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Microglial proliferation attenuates sickness responses in adult mice during endotoxin-induced inflammation

Torii

Takagi

Yoshimura

et al. 2022

Journal of Neuroimmunology

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Chemotherapy-related fever or infection fever?

Cited by 4 publications

References 13 publications

Metagenomic Next-Generation Sequencing in the Diagnosis of Infectious Fever During Myelosuppression Among Pediatric Patients with Hematological and Neoplastic Diseases

Metagenomic Next-Generation Sequencing in the Diagnosis of Infectious Fever During Myelosuppression Among Pediatric Patients with Hematological and Neoplastic Diseases

New paracetamol hybrids as anticancer and COX‐2 inhibitors: Synthesis, biological evaluation and docking studies

Microglial proliferation attenuates sickness responses in adult mice during endotoxin-induced inflammation

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