Chemotherapy regimen choice and patient outcomes in early-stage triple-negative breast cancer: a retrospective analysis

Ghafouri, Sanaz N.; Nayeri, Rebecca W; McAndrew, Nicholas P.; Hurvitz, Sara A.

doi:10.1177/17588359221085556

Cited by 2 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among various anticancer therapies, chemotherapy remains one of the most common and effective ways to destroy dividing cancer cells, alleviate tumor burden, improve cancer prognoses, and significantly increase survival rates. 4 However, while eliminating tumor cells, chemotherapy will inevitably damage normal cells, resulting in a series of side effects that negatively influence eating and diet, leading to malnutrition. 5 A healthy diet may alleviate adverse nutritional outcomes after chemotherapy among breast cancer patients and could improve patient quality of life during long-term treatment and survival.…”

Section: Introductionmentioning

confidence: 99%

Dietary Behavior and Its Association with Nutrition Literacy and Dietary Attitude Among Breast Cancer Patients Treated with Chemotherapy: A Multicenter Survey of Hospitals in China

Tang,

Wang,

Yan

et al. 2023

PPA

View full text Add to dashboard Cite

Background Chemotherapy often negatively impacts the nutritional status of breast cancer patients, and healthy dietary behaviors are important for patient wellbeing. With the guidance of the “Knowledge, Attitude and Practice model” (KAP model), the objective of this survey was to determine the frequency with which patients engage in healthy dietary behaviors and to explore the association between healthy dietary behaviors and nutrition literacy and dietary attitudes. Methods This study included a total of 284 breast cancer patients undergoing chemotherapy from three hospitals spanning three cities in China. Face-to-face interviews were conducted to collect demographic and clinical characteristics as well as the Dietary Nutritional Knowledge, Attitude and Practice Questionnaire (DNKAPQ) and the Nutrition Literacy Measurement Scale for Chinese Adult (NLMS-CA). Results Participants exhibited medium to high scores for nutrition literacy, dietary attitude and dietary behavior. Nutrition literacy ( r = 0.505, p < 0.001) and dietary attitude ( r = 0.326, p < 0.001) scores were both positively correlated with the total dietary behavior score. The total nutrition literacy score was positively correlated with the total dietary behavior score ( r = 0.286, p < 0.001). In the univariate analysis, age, body mass index, living environment, education level, monthly family income, work status, menopausal status, number of comorbidities, relapse and endocrine therapy were significantly associated with dietary behavior ( p < 0.05). In the multiple linear regression analysis, patients’ dietary behavior was significantly associated with nutrition literacy ( β = 0.449, p < 0.001) and dietary attitude ( β = 0.198, p < 0.001). These two factors accounted for 28.6% of the variation in the patients’ dietary behavior scores. Conclusion There is an important need for targeted dietary and nutritional interventions designed and implemented by health professionals to improve dietary behaviors. Intervention design and content should take the patients’ nutrition literacy and dietary attitudes into consideration. In particular, women who are older, overweight, unemployed, and postmenopausal and live in rural areas, exhibit fewer comorbidities, have a lower family income and education level, have not relapsed and are currently receiving endocrine therapy are in urgent need of diet-specific intervention.

show abstract

Section: Introductionmentioning

confidence: 99%