Chemotherapy Reduces Para-aortic Node Recurrences in Endometrial Cancer With Positive Pelvic and Unknown Para-aortic Nodes

Abstract

In the absence of local treatment (ie, para-aortic lymphadenectomy and radiotherapy), the administration of chemotherapy seems effective in reducing recurrences in the para-aortic area among patients with stage IIIC1 endometrioid EC.

Impact of depth and extent of lymphovascular space invasion on lymph node metastasis and recurrence patterns in endometrial cancer

“…Indeed, LVSI is known to be associated with increased risk of distant‐recurrence in other types of gynecologic malignancy , and systemic chemotherapy is suggested for LVSI‐positive cases to reduce the risk of recurrence . In support of this rationale, another study reported that additional chemotherapy reduces the risk of para‐aortic lymph node recurrence among patients with pelvic lymph node metastasis, a surrogate marker for deep and extensive LVSI patterns found in our study .…”

ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma

“…319 Multiple retrospective studies indicated a survival benefit in patients with advanced stage endometrial carcinoma treated with post-operative combined treatment including radiotherapy and chemotherapy, delivered by either the sandwich or sequential method, compared with radiotherapy alone or chemotherapy alone. [326][327][328][329][330][331][332][333][334][335][336][337][338][339][340][341][342][343][344] The benefit of added chemotherapy is unclear for patients with stage I-II clear cell carcinomas. These have often been included with serous as 'non-endometrioid carcinomas'.…”

ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma

“…The older pooled analysis of the NSGO-EORTC and MANGO-ILIADE trials used sequential chemotherapy and radiotherapy (either sequence) and reported significantly longer recurrence-free survival compared with radiotherapy alone 318 . Multiple retrospective studies indicated a survival benefit in advanced-stage endometrial carcinoma patients treated with post-operative combined treatment including radiotherapy and chemotherapy, delivered by either the sandwich or sequential method, compared to radiotherapy alone or chemotherapy alone [325][326][327][328][329][330][331][332][333][334][335][336][337][338][339][340][341][342][343] .…”