Chemotherapy or Radiation-Induced Oral Mucositis

Lalla, Rajesh V.; Saunders, Deborah; Peterson, Douglas E.

doi:10.1016/j.cden.2013.12.005

Cited by 147 publications

(138 citation statements)

References 27 publications

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“…The results on mucositis in this study are compared to several studies marked by MASCC/ISOO [7,9]. The number of patients without or with mucositis and mucositis grade I presented in this study (±70%) agree with other results described in the literature [3,25,26]. The green propolis has in its chemical constitution various flavonoids such as galangin and artepillin C, characterizing this compound as anti-inflammatory, antimicrobial and antioxidant [27,28].…”

Section: Discussionsupporting

confidence: 85%

“…In order to avoid these changes, the scientific community has been seeking ways to minimize adverse effects. The basic therapy of mucositis should include drugs that should have antifungal, antiinflammatory, antioxidants and healing effects [3,4,24]. The results on mucositis in this study are compared to several studies marked by MASCC/ISOO [7,9].…”

Section: Discussionmentioning

confidence: 96%

“…All these treatments increase the rate of comorbidities that can be reversible or irreversible [2]. Oral Mucositis refers to oral mucosa erythematous and ulcerative lesions observed in patients being treated with radiotherapy (RT) for head and neck cancer [3]. Mucositis is related as severe in 30.0-40.0% of the cases [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Propolis gel versus benzydamine in preventing oral mucositis for patients irradiated in head and neck: a preliminary study

Vras¹,

En²,

Fpcl³

et al. 2017

Cancer Rep Rev

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Oral Mucositis refers to oral mucosa erythematous and ulcerative lesions and is caused by radiation dispensed in the treatment of malignant tumors of the head and neck. Propolis shows several biological activities such as antimicrobial and anti-inflammatory properties. These biological activities should prevent a mucositis. The aim is to verify the effectiveness of Brazilian green propolis in a mucoadhesive gel, alcohol free, in preventing oral mucositis in patients that underwent radiotherapy. This research is characterized as a preliminary study with a mean duration of 12 weeks of patients' follow-up in two groups. The selection of participant's groups was randomized. The 26 selected patients were distributed between two groups, 13 in the benzydamine group and 13 in the propolis group. Patients were assessed on an average of 4.5 times totaling 116 diagnoses of mucositis. The percentage of patients who had mucositis greater or equal to 2 in this study was 30.6% for the benzydamine group and 29.6% for propolis gel. For these patients, the propolis gel shows a better performance in maintaining lower rates/grades and recovery of patients from the 17 th session of radiotherapy. This work shows a great possibility of further study in Phase III due to its good results and acceptance with patients.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 96%

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Propolis gel versus benzydamine in preventing oral mucositis for patients irradiated in head and neck: a preliminary study

Vras¹,

En²,

Fpcl³

et al. 2017

Cancer Rep Rev

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show abstract

“…The fourth level is the most severe form of mucositis, and occurs when stroma is exposed in the underlying conjuntive tissue. [2][3][6][7] There are ways to prevent or reduce the intensity of the mucositis. These include oral hygiene, rinsing using appropriate mouthwash, lip lubrication, appropriate nutrition, xerostomy control, cryotherapy, use of low-potency laser and suspension of substances and foods irritating to the mucosa, such as tobacco.…”

Section: Introductionmentioning

confidence: 99%

Prevention and Treatment of Mucositis at an Oncology Outpatient Clinic: A Collective Construction

Lopes

Rodrigues²,

Brasil³

et al. 2016

Texto contexto - enferm.

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ABSTRACT:The aim was to develop a nursing care protocol for the prevention and treatment of chemotherapy-induced mucositis at an outpatient clinic of a High Complexity Center in Oncology. A qualitative convergent-care research was undertaken. The construction of the protocol was driven by the criteria of Evidence-Based Practice. Data were collected from January to June 2013 in two steps. Firstly, we collected data on medical charts of customers to obtain sociodemographic and therapeutic data and nursing interventions performed for prevention, detection and treatment of mucositis. After this first step, workshops were held with the nurses to validate the available material and human resources, besides the feasible care to compose the protocol. Care was related to oral hygiene, mouth rinse, cryotherapy, laser therapy and interventions related to the nutritional scope. The implementation of this care protocol has standardized the care strategies. DESCRIPTORS: PREVENCIÓN Y TRATAMIENTO DE LA MUCOSITIS EN AMBULATORIO DE ONCOLOGÍA: UNA CONSTRUCCIÓN COLECTIVA RESUMEN:El objetivo fue elaborar un protocolo asistencial de enfermería para prevención y tratamiento de la mucositis inducida por quimioterapia en un ambulatorio de un Centro de Alta Complejidad en Oncología. Investigación cualitativa del tipo ConvergenteAsistencial. La construcción del protocolo fue orientada por los criterios de la Práctica Basada en Evidencias. La recopilación de datos fue realizada en el periodo de enero a junio de 2013 en dos etapas. Inicialmente, recopilamos datos en los historiales médicos de los clientes, con el fin de conocer datos sociodemográficos y terapéuticos e intervenciones de enfermería para prevención, detección y tratamiento de la mucositis. Después de esta primera etapa, se procedió a la realización de talleres con las enfermeras, con miras a la validación de los recursos materiales y humanos disponibles, además de los cuidados razonables para componer el protocolo. Han surgido cuidados relacionados con la higiene oral, enjuague bucal, crioterapia, terapia láser y intervenciones relacionadas con el ámbito nutricional. La implementación de este protocolo de cuidados estandarizó las estrategias de cuidado.DESCRIPTORES: Enfermería oncológica. Quimioterapia. Mucositis. Cuidados de enfermería.

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“…Oropharyngeal mucositis presents as mouth and throat erythema and ulcerations that are extremely painful and negatively impact oral intake [1]. Gastrointestinal mucositis may present as diarrhea, abdominal pain or nausea [2].…”

mentioning

confidence: 99%

Alleviating mucositis: are we on track for a novel therapeutic?

Lalla

2014

Expert Review of Gastroenterology & Hepatology

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Chemotherapy or Radiation-Induced Oral Mucositis

Cited by 147 publications

References 27 publications

Propolis gel versus benzydamine in preventing oral mucositis for patients irradiated in head and neck: a preliminary study

Propolis gel versus benzydamine in preventing oral mucositis for patients irradiated in head and neck: a preliminary study

Prevention and Treatment of Mucositis at an Oncology Outpatient Clinic: A Collective Construction

Alleviating mucositis: are we on track for a novel therapeutic?

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