Chemotherapy of Metastatic Ameloblastoma

Lanham, Richard J.

doi:10.1159/000226461

Cited by 35 publications

(3 citation statements)

References 8 publications

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“…One of these patients succumbed to AC and the response to this treatment was not described in the remaining cases. Several studies have also reported that this modality appears to have limited value in the treatment of AC ( 37 , 38 ).…”

Section: Discussionmentioning

confidence: 99%

Primary ameloblastic carcinoma of the maxilla: A case report and literature review

et al. 2014

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Ameloblastic carcinoma (AC) is a rare malignant odontogenic neoplasm that tends to occur in the mandible rather than in the maxilla. This malignancy is classified as a tumor that combines the morphological features of ameloblastoma and carcinoma, regardless of the presence or absence of metastasis. In addition, AC has been classified into two types, primary and secondary. The former develops de novo and the latter develops by malignant transformation of a pre-existing benign ameloblastoma. The present study describes the case of a 22-year-old patient with primary AC of the maxilla. A review of the literature focusing on the clinical details, treatment results and histopathological and phenotypic information available for ameloblastic carcinoma of the maxilla from a 60-year period was also performed. As a result, it was found that primary AC is dominant in the maxilla and does not exhibit an aggressive phenotype compared with secondary AC. In addition, the presence of recurrence was found to correlate with mortality, indicating that early, aggressive and complete removal of the tumor is the best treatment for survival.

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Section: Discussionmentioning

confidence: 99%

Primary ameloblastic carcinoma of the maxilla: A case report and literature review

et al. 2014

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“…A review of the literature made by Lanham concluded that chemotherapy failed to show any antitumoral activity, including doxorubicin, methotrexate, prednisolone, bleomycin, 5-fluorouracil and dacarbazin [14]. Moreover, the literature reports some patients with metastases showing long survival without receiving chemotherapy [6,15].…”

Section: Discussionmentioning

confidence: 99%

Metastatic ameloblastoma responding to combination chemotherapy: case report and review of the literature

et al. 2011

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BackgroundAmeloblastoma is a rare benign odontogenic tumor with locally aggressive behavior and a high recurrence rate. When metastases occur, which are uncommon, lungs constitute the most frequent site involved. Malignant ameloblastomas are different from ameloblastic carcinomas. Malignant ameloblastomas are tumors considered metastatic despite the appearance of well-differentiated or benign histology, while ameloblastic carcinomas are histologically malignant in both primary and metastatic sites.Case presentationA 24-year-old Moroccan man presented a malignant ameloblastoma of the mandible. The tumor was entirely resected. Five years later, a local recurrence occurred. Our patient was treated by exclusive radiotherapy with persistence of a residual disease. After two years he developed multiple lung metastases. Our patient received a combination chemotherapy using doxorubicin and cisplatin.ConclusionLess than 50 cases of ameloblastoma with metastases have been reported. There is still no standard treatment for metastatic ameloblastoma. Only through continuous reporting of such cases will clinicians be able to draw an optimal strategy for management of this pathology.

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“…Response to radiotherapy is unpredictable and it is usually used as a palliative modality for patients with inoperable metastatic deposits. While chemotherapy, especially combination chemotherapy had showed reduction in tumor size in limited reports,[ 5 ] but in most no improvement was noticed. [ 6 ]…”

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confidence: 99%

Cavitating lung metastasis secondary to ameloblastoma

et al. 2015

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Chemotherapy of Metastatic Ameloblastoma

Abstract: A case of metastatic ameloblastoma is presented which was resistant to treatment with adriamycin (doxorubicin), platinol (cis-platinum), Cytoxan (cyclophosphamide), dacarbazine (DTIC), and 5-fluorouracil (5-FU). The literature about treatment with chemotherapeutic agents is reviewed.

Cited by 35 publications

References 8 publications

Primary ameloblastic carcinoma of the maxilla: A case report and literature review

Primary ameloblastic carcinoma of the maxilla: A case report and literature review

Metastatic ameloblastoma responding to combination chemotherapy: case report and review of the literature

Cavitating lung metastasis secondary to ameloblastoma

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