Chemotherapy of Filariasis -On the Search of New Agents Effective on the Reproductive System of Female Adult Worms

Singh, Jujhar; Seth, M.; Fatma, Nigar; Sharma, Satyavan; Bhaduri, A. P.; Chatterjee, R. K.

doi:10.1515/znc-1990-11-1221

Zeitschrift Für Naturforschung C

1990

DOI: 10.1515/znc-1990-11-1221

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Chemotherapy of Filariasis -On the Search of New Agents Effective on the Reproductive System of Female Adult Worms

Jujhar Singh

M. Seth

Nigar Fatma

et al.

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Cited by 6 publications

(1 citation statement)

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“…Pyridoquinoline derivatives are less well known, but their antimalarial and antihelmintic activities have been described 6,. 7 Recent unpublished preclinical use of 4,6‐dialkoxy‐, 4,6‐bis(alkylamino)‐ and 4,6‐bis(alkylthio)pyrido[3,2‐ g ]quinoline derivatives, currently under development for their potential antimalarial, diuretic, clastogenic and antimicrobial characteristics, has also suggested that these compounds have antitumor properties 8. In these studies, which verify antiproliferative activity by cytotoxic assays in the cell types CHO‐K1 and A‐Mel‐3, three compounds (see Fig.…”

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Analysis of pyridoquinoline derivatives by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

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Balaña‐Fouce

et al. 2001

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A method using liquid chromatography/atmospheric pressure chemical ionization mass spectrometry (LC/APCI-MS) has been developed for the characterization and determination of pyridoquinoline derivatives 4,6-bis(dimethylaminoethylamino)-2,8,10-trimethylpyrido[3,2-g]quinoline, 4,6-bis(dimethylaminoethoxy)-2,8,10-trimethylpyrido[3,2-g]quinoline and 4,6-bis[(dimethylaminoethyl)thio]-2,8,10-trimethylpyrido[3,2-g] quinoline, all with potential antitumor properties. LC separation was performed on a conventional C18 column using a binary mobile phase composed of acetonitrile and 50 mM aqueous ammonium formate at pH 3. The APCI mass spectra obtained showed that proton addition giving [M + H]+ was the common mode of ionization to the amino- and thiopyridoquinolines, whereas the alkoxypyridoquinoline was identified by the main formation of the [M - (C2H3)N(CH3)2 + H]+, followed by the [M + H]+ ion. The LC separation conditions and MS detection parameters were optimized for the determination. The analytical method was also applied to the determination of these pyridoquinoline derivatives in fetal calf serum using liquid-liquid extraction with dichloromethane. Acceptable recovery values were obtained, ranging between 45 and 98%.

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confidence: 99%

Analysis of pyridoquinoline derivatives by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

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Font

Balaña‐Fouce

et al. 2001

Rapid Comm Mass Spectrometry

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Capillary liquid chromatography as a tool for separation of hydrophobic basic drugs. Relation between tests for column characterization and real analysis

Kafková

Tesařová²,

Suchánková

et al. 2003

J of Separation Science

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Capillary liquid chromatography as a tool for separation of hydrophobic basic drugs. Relation between tests for column characterization and real analysis Two capillary columns for reversed phase (RP) capillary liquid chromatography (CLC), viz. Nucleosil 100 -5 C18 and LiChrosorb RP-select B, were characterized by the Walters test, i.e. the chromatographic test proposed for RP stationary phases. Hydrophobicity indices were determined not only in acetonitrile/water mobile phase, as proposed in the test, but they were also measured in buffered systems. This approach was used to quantify the influence of mobile phase composition on the modification of the surface of the stationary phases. In the next step, small basic compounds differing in their hydrophobicity and basicity were selected and their retention on the stationary phases in mobile phases of the same composition as used for column testing was examined. Furthermore, the retention of newly synthesized drugs, chemotherapeutics derived from thioacridine and pyridoquinoline, differing in their structures, basicity, and hydrophobicity, was also studied. The composition of the mobile phases had to be shifted to higher contents of organic modifiers -acetonitrile or methanol -in order to elute these hydrophobic compounds from the columns. The question we wanted to answer was: How is the method for testing of reversed phases related to retention, separation efficiency, and peak symmetry of various analytes?

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Determination of new pyridoquinoline derivatives and their quantification in urine by capillary liquid chromatography

Srbek

Coufal²,

Tesařová

et al. 2003

J of Separation Science

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Determination of new pyridoquinoline derivatives and their quantification in urine by capillary liquid chromatographyCapillary liquid chromatography (CLC) in reversed separation mode was applied to the quantification and impurity profile determination of eight newly synthesized pyridoquinolines. The CLC separation system consisted of Nucleosil C18 stationary phase and methanol containing 1% (v/v) of triethylamine (TEA) as the mobile phase. The optimized separation system enabled the separation of impurities from the main component and their quantification in a reasonable analysis time. The presence of TEA in the mobile phase greatly improved the peak shape and decreased the analysis time of the studied derivatives on the C18 stationary phase. Calibration curves of pyridoquinolines were plotted in a concentration range from 1.0610 -6 to 1.0610 -3 mol/L at two parallel detector wavelengths of 254 and 265 nm and subsequently used for quantification of pyridoquinoline derivatives in human urine. No pretreatment of the real biological sample was needed. Detection and quantification limits were calculated for all the derivatives and the detection limits of most of the pyridoquinolines were found to lie in the lmol/L concentration range. The proposed CLC separation system has proved to be a suitable method for quantification of test derivatives in samples containing human urine matrix.

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Chemotherapy of Filariasis -On the Search of New Agents Effective on the Reproductive System of Female Adult Worms

Cited by 6 publications

References 4 publications

Analysis of pyridoquinoline derivatives by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

Analysis of pyridoquinoline derivatives by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

Capillary liquid chromatography as a tool for separation of hydrophobic basic drugs. Relation between tests for column characterization and real analysis

Determination of new pyridoquinoline derivatives and their quantification in urine by capillary liquid chromatography

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