Chemotherapy of Childhood Hodgkin's Disease in Uganda

Ziegler, J. L.; Fass, Leroy; Bluming, A Z; Magrath, I. T.; Templeton, A. C.

doi:10.1016/s0140-6736(72)92088-0

Cited by 45 publications

(17 citation statements)

References 6 publications

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“…This finding must be qualified by the small number of patients in the chemotherapy group, and by the fact that 7/10 children treated primarily by chemotherapy are still less than 2 years from the start of treatment. Nevertheless, our data so far support those of Ziegler et al (1972) and Olweny et al (1974) who gave combination chemotherapy to Ugandan children with early-stage disease, albeit of different histological distribution to our series, and achieved results comparable with other series where treatment was by conventional extended-field radiotherapy. Combination chemotherapy has its own disadvantages: sterility in males, at least for a time after treatment, is almost inevitable although the extent to which this will remain a longterm problem in male children is so far unknown.…”

Section: Stagingsupporting

confidence: 91%

“…Extended-field radiotherapy employing "Mantle", "inverted Y", or "total nodal" techniques (for definition see Table I) for local disease is at present considered by many to be the treatment of choice in children as well as adults (Jenkin et al, 1975;Young et al, 1973). On the other hand Fuller, Sullivan and Butler (1973) have shown that local radiotherapy (see Table I (Ziegler et al, 1972;Olweny et al, 1974 1941 and 1947, 7 from 1950 to 1959, 12 from 1960 to 1969 and 39 from 1970 to 1975. Thirty-seven children were boys and 22 girls.…”

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confidence: 99%

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Hodgkin's Disease in Children

Smith¹,

Peckham²,

McElwain³

et al. 1977

Br J Cancer

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Summary.-Fifty-nine children with Hodgkin's disease were seen over a 34-year period. Compared with Hodgkin's disease in adults, there was an increased male incidence, especially in the younger children. This was associated with an increased male incidence of lymphocyte-predominant histology. Forty-six patients underwent lymphography as part of their staging, and 13 had staging laparotomies. The 5-year survival for the entire group was 85%, with a median survival of 10 years. Response to radiotherapy in children with Stages I-IIIA disease was: 12 children treated with involved-field radiotherapy after inadequate clinical staging had a 3-year remission rate of 13%, and a median length of remission of 18 months; 24 children treated with extended-field radiotherapy after adequate clinical staging, including lymphography, had a 3-year remission rate of 72%, and a median duration of remission not yet reached; 3 children treated with elective local radiotherapy for Stage IA disease after intensive clinical staging remain in complete remission for periods of up to 34 months. Eight out of 10 children with Stages IIIB-IV disease, treated with combination chemotherapy, achieved complete remission with a 3-year remission rate of 70%; 7 children treated with combination chemotherapy following relapse after radiotherapy all achieved complete remission with a 3-year complete remission rate of 66%. Thirteen children underwent laparotomy and splenectomy as a staging procedure. Five were found to have intra-abdominal disease, including 4 with splenic involvement. These results show that there is no place for involved-field radiotherapy after inadequate clinical staging, in the management of childhood Hodgkin's disease. Extended-field radiotherapy after adequate staging, and combination chemotherapy, produce results which are as good as those for adults, but the benefits of these treatments and of staging laparotomy must be balanced against the possible complications when they are used in children. These problems are discussed and a scheme of management is proposed.

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Section: Stagingsupporting

confidence: 91%

mentioning

confidence: 99%

Hodgkin's Disease in Children

Smith¹,

Peckham²,

McElwain³

et al. 1977

Br J Cancer

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“…Ziegler et al [21] reported survival rates of 65% in CS I and CS II children following MOPP chemotherapy alone. Olweny et al [6] later updated these data and reported survival rates of 75% and 60% for early and late stage patients, respectively.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Hodgkin's disease in children with alternating mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) and adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) courses without radiotherapy

Berg

Stuve

Behrendt

1997

Med. Pediatr. Oncol.

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“…On the other hand, it is also possible that all the leukemic cells were killed by the original chemotherapy and that the so-called late relapse is a consequence of reinduction of a second bout of leukemia, due to persistance of an oncogenic virus. Recently, Ziegler has reported data on Burkitt's lymphoma that make it seem more likely the latter is the case (28). He has shown two patterns of relapse.…”

Section: Introductionmentioning

confidence: 99%

Chemical Control of Cancer

Zubrod

1972

Proc. Natl. Acad. Sci. U.S.A.

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Improvement of the present mortality from cancer depends upon a means of controlling those cancers that have spread from the original site to distant organs. Killing of tumor cells by means of drugs, whether used by themselves or in combination with surgery or irradiation, provides the strategy most likely to achieve this goal in the near future. There are now 10 disseminated cancers in man wherein drug treatment has resulted in normal life expectancy. The biological pattern of growth of these tumors is different from that of the tumors that have not been so susceptible to drugs. The new knowledge concerning the interdependence of growth pattern and drug susceptibility has led to rational animal models for selection of active drugs, in which more confidence can be placed than upon empiric models. Similarly, the prediction of drug toxicity and pharmacology from animal models has been placed on a firm scientific base. Recent developments in molecular biochemistry hold forth the hope that some day the selection of safe and effective antitumor drugs may be based on a knowledge of in vitro biochemistry.

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Chemotherapy of Childhood Hodgkin's Disease in Uganda

Cited by 45 publications

References 6 publications

Hodgkin's Disease in Children

Hodgkin's Disease in Children

Treatment of Hodgkin's disease in children with alternating mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) and adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) courses without radiotherapy

Chemical Control of Cancer

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