Chemotherapy induces stemness in osteosarcoma cells through activation of Wnt/β-catenin signaling

Martins-Neves, Sara R.; Paiva-Oliveira, Daniela I.; Wijers-Koster, Pauline M.; Abrunhosa, Antero; Ribeiro, Carlos; Bovée, Judith V.M.G.; Cleton‐Jansen, Anne‐Marie; Gomes, Célia

doi:10.1016/j.canlet.2015.11.013

Cited by 99 publications

(90 citation statements)

References 45 publications

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“…Tumour cells can switch in and out of a stem cell phenotype further increasing the complexity of the cancer stem cell hypothesis and suggesting that environmental pressure (experimental or in patients) may be a trigger for heterogeneity and plasticity. For example increased environmental pressure through chemotherapy treatment has the potential to induce a switch from a differentiated towards a stem-like phenotype in osteosarcoma (43)(44)(45)(46). This potential plasticity and the many different experimental enrichment methods may help to understand the variations of reported CSC markers between studies.…”

Section: Resultsmentioning

confidence: 99%

“…The exploitation of chemoresistant cancer cell traits was also used by Martins-Neves et al (43) Collectively the reports using chemotherapeutics show that a CSC phenotype can be induced through therapeutic challenge. It remains to be established whether different chemotherapeutic challenges will give rise to different CSC sub-populations.…”

Section: Induction Of Cancer Stem Cell Phenotype Through Chemotherapementioning

confidence: 99%

“…This chemoresistant characteristic has been exploited in a few studies investigating whether chemotherapy treated or treatmentresistant cells could contain CSCs (43)(44)(45)(46). Indeed, it was shown that methotrexate pretreated or resistant cells not only expressed CD117 + /Stro-1 + and had a side population but that these cells also formed more spheres in vitro and were more tumorigenic when injected subcutaneously into immunodeficient mice (44).…”

Section: Induction Of Cancer Stem Cell Phenotype Through Chemotherapementioning

confidence: 99%

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Cancer stem cells in osteosarcoma

2017

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Abstract:Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis.Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therapeutic targets. Cancer stem cells (CSC) represent a sub-type of tumour cells attributed to critical steps in cancer including tumour propagation, therapy resistance, recurrence and in some cases metastasis. Recent published work demonstrates evidence of cancer stem cell phenotypes in osteosarcoma with links to drug resistance and tumorigenesis. In this review we will discuss the commonly used isolation techniques for cancer stem cells in osteosarcoma as well as the identified biochemical and molecular markers.

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Section: Resultsmentioning

confidence: 99%

Section: Induction Of Cancer Stem Cell Phenotype Through Chemotherapementioning

confidence: 99%

Section: Induction Of Cancer Stem Cell Phenotype Through Chemotherapementioning

confidence: 99%

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Cancer stem cells in osteosarcoma

2017

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“…In particular, activation of Wnt/b-catenin is associated not only with presence of cancer stem cell population but also with cell transition to a cancer stem-like phenotype in OS cells following treatment with chemotherapy, thereby implying that this mechanism confers drug resistance to cancer cells. 32,33 Non-canonical Wnt signaling involves b-cateninindependent pathways such as Wnt/Ca 2þ , Wnt/planar cell polarity (PCP), and Wnt/PKA pathways. 18 These Wnt pathways are mediated through frizzleds and alternative co-receptors named receptor tyrosine kinase-like orphan receptors (RORs) and receptor-like tyrosine kinase.…”

Section: Wnt Pathwaymentioning

confidence: 99%

Deciphering signaling networks in osteosarcoma pathobiology

Adamopoulos

Gargalionis

Basdra

et al. 2016

Exp Biol Med (Maywood)

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Osteosarcoma is the most frequent type of primary bone tumors among children and adolescents. During the past years, little progress has been made regarding prognosis of osteosarcoma patients, especially for those with metastatic disease. Genomic instability and gene alterations are common, but current data do not reveal a consistent and repeatable pattern of osteosarcoma development, thus paralleling the tumor's high heterogeneity. Critical signal transduction pathways have been implicated in osteosarcoma pathobiology and are being evaluated as therapeutic targets, including receptor activator for nuclear factor-kB (RANK), Wnt, Notch, phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin, and mechanotransduction pathways. Herein, we recapitulate and discuss recent advances in the context of molecular mechanisms and signaling networks that contribute to osteosarcoma progression and metastasis, towards patient-tailored and novel-targeted treatments.

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“…Surgery and radiotherapy cannot remove and kill metastatic tumor cells, and most of the currently used chemotherapy drugs have serious side effects that greatly reduce the therapeutic outcome and quality of life of patients [2]. Moreover, some chemotherapy drugs can induce normal tumor cells to become tumor stem cells, thus accelerating tumor invasion and metastasis [3]. It is therefore of utmost importance to develop nontoxic and efficient drugs to inhibit the invasion and metastasis of lung cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Radix Glehniae extract inhibits migration and invasion of lung cancer cells

Wang¹,

Li²,

Lin³

et al. 2018

Infection International

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Objective: The aim of this study was to investigate the effect of Radix Glehniae on the migration and invasion abilities of lung cancer cells. Methods:Normal bronchial cell line 16HBE and lung cancer cell line SK-MES-1 were treated with Radix Glehniae extract. Proliferation, migration, and invasion abilities were determined by Cell Counting Kit (CCK)-8, Transwell, and Matrigel assays, respectively. The expression and secretion levels of tissue inhibitor of metalloproteinases 2 were detected by quantitative PCR and enzyme-linked immunosorbent assay, respectively. Results:Radix Glehniae extract inhibited the migration and invasion abilities of SK-MES-1 cells and enhanced TIMP2 expression and secretion by SK-MES-1 cells, without causing toxicity to 16HBE cells. Conclusion:Radix Glehniae is useful in lung cancer treatment.

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Chemotherapy induces stemness in osteosarcoma cells through activation of Wnt/β-catenin signaling

Cited by 99 publications

References 45 publications

Cancer stem cells in osteosarcoma

Cancer stem cells in osteosarcoma

Deciphering signaling networks in osteosarcoma pathobiology

Radix Glehniae extract inhibits migration and invasion of lung cancer cells

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