Chemotherapy-induced Takotsubo cardiomyopathy, a case report and review of the literature

Coen, Matteo; Rigamonti, Fabio; Roth, Arnaud; Koessler, Thibaud

doi:10.1186/s12885-017-3384-4

Cited by 37 publications

(20 citation statements)

References 39 publications

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“…The exact incidence of TTE changes and heart failure has not been studied thoroughly. There have been multiple reports of patients presenting with reversible cardiomyopathies, without evidence of coronary artery occlusion, consistent with features of SCM 29–35. Although our case did have non-obstructive coronaries and complete reversibility of LV dysfunction, the presence of global hypokinesis pattern is not a part of Mayo clinical criteria36 and is not commonly described in SCM 37.…”

Section: Discussionmentioning

confidence: 47%

Acute reversible left ventricular systolic dysfunction associated with 5-fluorouracil therapy: a rare and increasingly recognised cardiotoxicity of a commonly used drug

et al. 2019

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5-Fluorouracil (5-FU) is the third most common chemotherapeutic agent for treating solid cancers and the second most common to cause cardiotoxicity. We present a rare case of acute reversible severe left ventricular systolic dysfunction associated with 5-FU. A 54-year-old woman with a history of stage IV gastric cancer presented with features of transient ischaemic attack after receiving the first dose of FLOT (5-FU, leucovorin, oxaliplatin and docetaxel). During the diagnostic workup, it was found that her ejection fraction was severely reduced to 15% with features of global hypokinesis, which later improved back to 65% within 13 days. These cases challenge our current understanding of the underlying mechanisms of this cardiotoxicity. Additionally, even though the patient did not experience any cardiac symptoms, it is important to monitor these patients closely as they are at high risk for fatal complications like arrhythmia and thrombus formation.

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Section: Discussionmentioning

confidence: 47%

Acute reversible left ventricular systolic dysfunction associated with 5-fluorouracil therapy: a rare and increasingly recognised cardiotoxicity of a commonly used drug

et al. 2019

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“…In addition, we observed that the relative death risk from non‐cancer causes was higher for patients with only 2–11 months follow‐up time. It is a well‐established fact that chemotherapy is associated with better cancer survivorship on the one hand, but on the other hand, patients suffer from the chemotherapy‐associated toxicities with some even showing long‐term side effects including heart and lung diseases 35‐38 . The situation is similar for radiotherapy in RC 39 .…”

Section: Discussionmentioning

confidence: 99%

Analyzing non‐cancer causes of death of colorectal carcinoma patients in the US population for the years 2000–2016

Zhang

et al. 2020

Cancer Medicine

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Background Colorectal cancer (CRC) treatment and patient survival improved greatly. Consequently an increased incidence of non‐cancer‐related deaths is observed. This study analyzed the causes of non‐cancer death for people suffering from CRC based on the year of diagnosis, follow‐up time, and patient's age. Methods The data from patients diagnosed with CRC in the years 2000–2016 were taken from the Surveillance, Epidemiology, and End Results 18 database. Patients were categorized according to: death from CRC, non‐CRC cancer, and non‐cancer. Constituent ratios and standardized mortality ratios (SMRs) were calculated to describe the death causes distribution and relative death risks. Results Between 2000 and 2016, a stable and rapid drop for the original diagnosis as death cause for CRC patients was observed (70.19% to 49.35%). This was coupled to an increase in non‐cancer‐associated death reasons (23.38% to 40.00%). The most common non‐cancer death cause was heart disease, especially for elderly patients. However, deaths from accidents and adverse effects were frequent in younger CRC patients. Patients died from septicemia more often within the first follow‐up year; however, a 6‐fold increase in death from Alzheimer's disease was found for after at least 180 months follow‐up time. The SMRs of all 25 non‐cancer death causes initially decreased in all CRC subgroups, followed by an increase with follow‐up times. Gradually decreasing SMR values were observed with increasing age of CRC patients. Conclusions These findings could help modify and sharpen preventive measures and clinical management and raise physician's awareness to potential non‐CRC death risk factors for CRC patients.

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“…Takotsubo syndrome (TTS) is increasingly being reported in patients with cancer and in those undergoing chemotherapy. Up to 29% of patients admitted with a final diagnosis of stress TTS have had cancer . Several cases of TTS have been described in patients taking oncology drugs including fluoropyrimidines (5‐fluorouracil, capecitabine), molecular‐targeted agents (sunitinib, bevacizumab, trastuzumab), and cisplatin …”

Section: Vigibase® Analysis: Characteristics Of Patients With Stress mentioning

confidence: 99%

Takotsubo syndrome in patients with cancer treated with immune checkpoint inhibitors: a new adverse cardiac complication

Éderhy

Dolladille

Thuny

et al. 2019

European J of Heart Fail

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Chemotherapy-induced Takotsubo cardiomyopathy, a case report and review of the literature

Cited by 37 publications

References 39 publications

Acute reversible left ventricular systolic dysfunction associated with 5-fluorouracil therapy: a rare and increasingly recognised cardiotoxicity of a commonly used drug

Acute reversible left ventricular systolic dysfunction associated with 5-fluorouracil therapy: a rare and increasingly recognised cardiotoxicity of a commonly used drug

Analyzing non‐cancer causes of death of colorectal carcinoma patients in the US population for the years 2000–2016

Takotsubo syndrome in patients with cancer treated with immune checkpoint inhibitors: a new adverse cardiac complication

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