Chemotherapy-induced reticulate pigmentation in three Indian patients including a case in the pediatric age group

Kumar, Sheetanshu; Bhattacharjee, Rajsmita; Kambhampati, Sindhura Bala Naga; Kanwar, Amrinder J.; Vinay, Keshavamurthy

doi:10.25259/ijdvl_216_20

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Interestingly, the histopathologic findings reported were similar to lichen planus pigmentosus [17,18]. Chemotherapeutic drugs, such as paclitaxel, cyclophosphamide, 5-fluorouracil, idarubicin, ifosfamide, and cytarabine, have also been implicated to cause reticulated pigmentation [19]. However, previous reports have used multiple chemotherapeutic drugs, and implicating its association in the development of reticulated pigmentation is quite limited [20].…”

Section: Reticulated Pigmentationmentioning

confidence: 96%

Drug-Induced Pigmentation

Preclaro¹

2023

Pigmentation Disorders - Etiology and Recent Advances in Treatments

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Drug-induced pigmentation occurs in up to 20% of acquired pigmentary disorders of the skin. Association of its occurrence was reported in certain drugs, including alkylating/cytotoxic agents, analgesics, antiarrhythmics, anticoagulants, antiepileptics, antimalarials, antimicrobials, antiretrovirals, metals, prostaglandin analogs, and psychotropic agents, among others. Proposed mechanisms include (1) accumulation of melanin, (2) accumulation of drug, (3) generation of new pigment, and (4) deposition of iron. Though difficult to confirm the drug association, the history, with emphasis on currently used drugs, and clinical examination may guide practitioners to an accurate diagnosis. Treatment options include cessation of the drug, adequate sun protection, and non-ablative pigment lasers.

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Section: Reticulated Pigmentationmentioning

confidence: 96%

Drug-Induced Pigmentation

Preclaro¹

2023

Pigmentation Disorders - Etiology and Recent Advances in Treatments

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Gemcitabine, a rare cause of chemotherapy-related reticulate hyperpigmentation

Savoia,

Medri,

Passardi

et al. 2024

Dermatol Reports

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Reticulate pigmentary disorders can be classified into inherited or acquired and cutaneous drug- induced reticulate hyperpigmentation belongs to this last group. The list of the drugs involved is constantly increasing and chemotherapy agents are frequently implicated. We report a new case of chemotherapy-related reticulate hyperpigmentation to gemcitabine, even though a previous chemotherapy with nanoparticle, albumin-bound (Nab®) paclitaxel and gemcitabine may have promoted the onset of the disease. Reassurance of the patients is important in these cases, in order to continue the chemotherapy, and gradual fading of the hyperpigmentation is usually observed, as in our case.

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Chemotherapy-induced reticulate pigmentation in three Indian patients including a case in the pediatric age group

Abstract: induced reticulate pigmentation in three Indian patients including a case in pediatric age group.

Cited by 2 publications

References 5 publications

Drug-Induced Pigmentation

Drug-Induced Pigmentation

Gemcitabine, a rare cause of chemotherapy-related reticulate hyperpigmentation

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