2001
DOI: 10.1007/bf02712689
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Chemotherapy-induced pulmonary toxicity in lung cancer management

Abstract: Because of their own prognostic and therapeuthic implications the following etiologies have to be firstly considered in the initial diagnostic approach: lung infection, either by conventional pathogens or atypical microorganisms, malignancy-related thromboembolic pulmonary disease, local tumor progression, iatrogenic intra-alveolar hemorrhage, radiotherapy-induced adverse effects, transfusion reactions, postoperative complications

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“…It is used alone or in conjugation with other antineoplastic drugs against a wide variety of malignancies [8][9][10]. Yet, the clinical use of ETP is often limited due to its toxic effects on organs including liver, kidney, heart and lungs [11][12][13][14][15][16]. ETP exerts its cytotoxic effect by impairing the activity of topoisomerase II enzyme which eventually results in single-and double-stranded DNA breaks during DNA replication.…”
Section: Introductionmentioning
confidence: 99%
“…It is used alone or in conjugation with other antineoplastic drugs against a wide variety of malignancies [8][9][10]. Yet, the clinical use of ETP is often limited due to its toxic effects on organs including liver, kidney, heart and lungs [11][12][13][14][15][16]. ETP exerts its cytotoxic effect by impairing the activity of topoisomerase II enzyme which eventually results in single-and double-stranded DNA breaks during DNA replication.…”
Section: Introductionmentioning
confidence: 99%