Chemotherapy-induced neutropenia as a prognostic factor in patients with advanced non-small cell lung cancer treated with front-line docetaxel–gemcitabine chemotherapy

Chemotherapy-induced neutropenia as a prognostic factor in advanced non-small-cell lung cancer: results from Japan Multinational Trial Organization LC00-03

“…Furthermore, severe neutropenia (grade 3 -4) was no better than mild neutropenia (grade 1 -2) for prediction of overall survival. As a whole, these results are consistent with previous reports of the chemotherapy of NSCLC and gastric cancer (Di Maio et al, 2005;Yamanaka et al, 2007;Pallis et al, 2008), and strongly suggest that neutropenia per se is not important, but the use of neutropenia to reflect that an adequate dose has been given.…”

“…A recent study by Di Maio et al (2005) confirmed the positive correlation between chemotherapy-induced neutropenia and increased survival in a pooled analysis of three randomised trials, which included 1265 patients with advanced non-small-cell lung cancer (NSCLC). Pallis et al (2008) have also shown the association between chemotherapy-induced neutropenia and better clinical outcome for patients with NSCLC. In a prospective survey of oral fluoropyrimidine S-1 in 1055 patients with advanced gastric cancer, Yamanaka et al (2007) reported that patients with moderate (grade-2) neutropenia had the longest survival.…”

Impact of granulocyte colony–stimulating factors in metastatic colorectal cancer patients

“…A number of studies have also looked specifically at chemotherapy-induced neutropenia and survival. Studies in gastric, ovarian, breast, and lung cancers have all shown that survival was improved in patients who experienced neutropenia while on chemotherapy compared with patients who did not [31][32][33][34][35][36] .…”

The Effect of Haematological Parameters on Overall Survival in Advanced Stage Non Small Cell Lung Cancer.

“…19 Besides the presence of tumor related leucocytosis, a pooled analysis of an Italian group data from about 20 Also Pallis et al suggested that chemotherapy induced neutropenia was an independent prognopstic factor for survival. 21 Later Maione et al hypothesized if the prognostic value of chemotherapy induced neutropenia being affected by the presence of tumor related leucocytosis and if these two groups were in fact the representatives of the same population. 22 But this is still an era to be lightened by prospective trials.…”