Chemotherapy-Induced Nausea, Vomiting, and Fatigue – the Role of Individual Differences Related to Sensory Perception and Autonomic Reactivity

Zachariae, Robert; Paulsen, KD; Mehlsen, Mimi; Jensen, A. B.; Johansson, Anna L.V.; Maase, Hans von der

doi:10.1159/000107566

Cited by 42 publications

(31 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is generally accepted that chemotherapy induces fatigue. 41 However, the different compounds seem to have an interindividual association of variable strength. Different effects of prednisolone have been previously documented in the literature.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated With Fatigue in Sarcoidosis

Fleischer¹,

Hinz²,

Brähler³

et al. 2013

Respir Care

View full text Add to dashboard Cite

BACKGROUND: Fatigue is a frequent symptom of patients with sarcoidosis. The origin of fatigue associated with sarcoidosis is unclear. The aim of this study was to assess the impact of affected organs, medication, and comorbidity on fatigue related to sarcoidosis. METHOD: In collaboration with the German Sarcoidosis Society, a sample of 1,197 subjects diagnosed with sarcoidosis was examined. The participants completed a questionnaire that contained the Fatigue Assessment Scale and the Multidimensional Fatigue Inventory. RESULTS: In this study, muscles, bones, and nerves were most strongly associated with fatigue. Patients receiving prednisolone showed heightened fatigue levels. However, the association between the duration of prednisolone therapy and fatigue was weak. The concomitant diseases, pulmonary hypertension and sleep apnea, showed the greatest impact elevating fatigue (effect sizes d > 0.50). In the combined regression analysis, comorbidity was the most important predictor of fatigue. CONCLUSIONS: It is important to consider that multiple clinical factors, especially comorbidities, contribute to the high degrees of fatigue in sarcoidosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Factors Associated With Fatigue in Sarcoidosis

Fleischer¹,

Hinz²,

Brähler³

et al. 2013

Respir Care

View full text Add to dashboard Cite

show abstract

“…Autonomic imbalance, such as a state of low heart rate variability, may be associated with a wide range of psychological and medical dysfunctions [84] and may affect response to medical treatments [85]. …”

Section: Finding Pathophysiological Linksmentioning

confidence: 99%

Psychosomatic Assessment

Fava

Sonino²

2009

Psychother Psychosom

View full text Add to dashboard Cite

The primary goal of psychosomatic medicine is the incorporation of its operational strategies into clinical practice. The traditional attitude toward disease and the functional/organic dichotomy were criticized by George Engel in the early sixties. Only recently, however, there has been increasing awareness of the limitations of disease as the primary focus of medical care. It is not that certain disorders lack an organic explanation; it is our assessment that is inadequate in most clinical encounters. The research evidence which has accumulated in psychosomatic medicine offers unprecedented opportunities for the identification and treatment of medical problems. Taking full advantage of clinimetric methods (such as the use of Emmelkamp’s two levels of functional analysis and the Diagnostic Criteria for Psychosomatic Research) may greatly improve the clinical process, including shared decision making and self-management. Endorsement of the psychosomatic perspective may better clarify the pathophysiological links and mechanisms underlying symptom presentation. Pointing to individually targeted methods may improve final outcomes and quality of life.

show abstract

“…Patients deal with several challenges, including the emotional consequences of being diagnosed with a life-threatening illness [1][2][3] ; medical treatments with sometimes debilitating side effects, such as nausea and vomiting, pain, urinary incontinence, fatigue, bodily disfigurement, sexual dysfunction, neuropathies, difficulties breathing, eating, and/or swallowing [4][5][6][7][8][9][10][11] ; and existential and spiritual concerns. 12,13 However, the diagnosis of cancer in a member of the family can have significant repercussions for the entire family.…”

mentioning

confidence: 99%