“…Transient and prolonged amenorrhea was more frequent with CMF-and CEF/CAF-type regimens compared with AC (Bines et al 1996), presumably due to a higher cumulative dose of cyclophosphamide received. Addition of taxanes has shown to increase the risk of CIA, particularly in the first year, in many (Martin et al 2005, Tham et al 2007, Han et al 2009, Swain et al 2009, Najafi et al 2011 but not in all trials (Davis et al 2005, Fornier et al 2005, Berliere et al 2008, Perez-Fidalgo et al 2010, Zhou et al 2010. However, comparison of rates of CIA across different studies is limited by considerable differences in treatments used, median age of patients, prevalence of endocrine-responsive disease, follow-up duration, and variability in the definition of CIA (from 3 months to O1 year absence of menses).…”