Chemotherapy in alveolar soft part sarcomas

Reichardt, Peter; Lindner, T.; Pink, Daniel; Thuss‐Patience, Peter; Kretzschmar, Albrecht; Dörken, Bernd

doi:10.1016/s0959-8049(03)00264-8

Cited by 112 publications

(95 citation statements)

References 42 publications

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“…1,19,20 The reason for this high incidence of brain metastases is unknown. In our series, 43% (10/23) of patients had brain metastases.…”

Section: Resultsmentioning

confidence: 99%

Imaging features of primary and metastatic alveolar soft part sarcoma: single institute experience in 25 patients

Sood¹,

Baheti²,

Shinagare³

et al. 2014

BJR

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Objective: To describe imaging features of primary and metastatic alveolar soft part sarcoma (ASPS). Methods: In this institutional review board-approved and Health Insurance Portability and Accountability Actcompliant retrospective study, 25 patients (14 males; mean age, 25 years; range, 18-40 years) with pathologically proven ASPS seen at our institute between 1995 and 2013 were included. Imaging of primary tumours in 5 patients and follow-up imaging in 25 patients were reviewed by 2 radiologists in consensus. Clinical information was obtained from electronic medical records. Results: The most common sites for the primary tumour were extremities (17/25, 68%) and torso (6/25, 24%). Primary tumours (n 5 5) were well circumscribed, compared with skeletal muscle, were isodense on CT, hyperintense on T 1 and T 2 weighted images with intense post-contrast enhancement, prominent feeders on CT and flow voids on MRI. Metastases developed in 23/25 (92%) patients, 18 at presentation. The most common sites of metastases were the lungs (100%), lymph nodes (74%), bones (57%) and brain (43%). Visceral and nodal metastases were hypervascular. At the time of reporting the results, 15 patients have died, 6 are alive and 4 were lost to follow-up. Median survival was 74 months for those without brain metastases (n 5 8) and 60 months for those with brain metastases (n 5 7). Median survival was shorter for patients with metastases at presentation. Conclusion: ASPS most commonly involves the lower extremities of young adults, is hypervascular on imaging, often metastasizes at presentation, frequently to lung, nodes, bones and brain, and has an indolent course despite metastases. Brain metastases and high tumour burden (number of metastatic sites) at presentation decreased survival in our study. Advances in knowledge: ASPS has an unusual pattern of metastases to the brain and nodes in addition to lung and bones. It has an indolent course despite metastases.

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“…1,19,20 The reason for this high incidence of brain metastases is unknown. In our series, 43% (10/23) of patients had brain metastases.…”

Section: Resultsmentioning

confidence: 99%

Imaging features of primary and metastatic alveolar soft part sarcoma: single institute experience in 25 patients

Sood¹,

Baheti²,

Shinagare³

et al. 2014

BJR

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“…However, whether postoperative radiotherapies are required remains to be elucidated. ASPS associated with brain metastasis has been observed to be insensitive to chemotherapeutic drugs, therefore no specific chemotherapeutic treatment regimens have been developed (12). Notably, the patient in the present case received 30 radiotherapy doses at 60 Gy per dose and was administered 4 courses of chemotherapy with doxorubicin and ifosfamide.…”

Section: Discussionmentioning

confidence: 91%

Alveolar soft part sarcoma associated with lung and brain metastases: A case report

Wang

Huan

et al. 2016

Oncology Letters

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Abstract. The present case report aimed to improve the understanding of alveolar soft part sarcoma (ASPS) by investigating the clinical characteristics, diagnosis and therapeutic methods used to treat ASPS associated with lung and brain metastases. The clinical data of a single patient diagnosed with ASPS by postoperative pathology was studied retrospectively, and additional associated reports and previous studies of similar cases were reviewed. Clinical symptoms were markedly alleviated following surgical treatment, followed by a chemotherapy regime. During post-treatment follow-up, no tumor recurrence was observed. IntroductionAlveolar soft part sarcoma (ASPS) is a clinically rare soft tissue sarcoma (STS) of unknown histological origin, accounting for 0.5-1.0% of all STS cases, worldwide (1). ASPS associated with lung and brain metastases is a rare disease with poor prognosis, with a high risk of metastasis to the brain. Surgery is typically the primary method used in the treatment of ASPS (2). The present study outlines the case of a patient with ASPS and associated lung and brain metastases. The patient provided signed informed consent, and therefore the case is detailed in the following report, including the course of disease and patient outcome. Case reportA 39-year-old male patient was admitted to the People's Hospital of Linyi City of Shandong Province (Linyi, China) on 3 January 2014, after experiencing occasional headaches during the previous 6 months. The patient's headaches had become progressively more severe 1 month prior to admission to hospital, and were associated with right upper limb weakness and inaccurate fine motor movements. Physical examination revealed negative cranial nerve-associated signs. Breath sounds were clear in both lungs, and no rhonchi or moist rales were heard. Distal right upper limb muscle strength received grade 4 (3), and tendon reflex and pathological signs were negative. As revealed by cranial computed tomography (CT; Fig. 1A), a high-density lesion was observed in the left postfrontal area [CT values, 52 Hounsfield units, (HU)] and a peripheral low-density edematous zone was visible. Magnetic resonance imaging (MRI) was also performed and revealed an irregular lump in the left frontal lobe with T1 and T2 hyperintensity. The surrounding vessels were belt-like and anfractuous with no intensified edematous regions (Fig. 1B-D). The medical history of the patient included resection of a subcutaneous mass in the left lower limb 10 years previously, which recurred 5 years later and required a second surgery. The masses resected during these earlier surgeries had not been sent for pathological examination. The patient reported no family history of the manifestations described above. Subsequently, the patient was further examined using chest radiography, which indicated multiple pulmonary nodules on both lungs. Therefore, the patient underwent single-photon emission CT/CT, which revealed no significant abnormalities on a whole-body bone scan (Fig. 1E). The chest CT result (Fig...

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“…The most common metastatic sites are the lung, brain, bone and metastatic disease [5]. Various chemotherapeutic regimens have shown only a limited benefit in the treatment of ASPS [7]. Hence, chemotherapy as an adjuvant treatment, is not recommended.…”

Section: Discussionmentioning

confidence: 99%

“…All the margins were negative, but the deep the liver [6]. It has been reported that ASPS has a high incidence of brain metastases (about 30%), almost three times higher than other soft tissue sarcomas [1,7].…”

Section: Case Reportmentioning

confidence: 99%

Alveolar Soft Part Sarcoma-A Histological Surprise in a Male Patient who was Suspected to have Breast Cancer

Varghese

Balukrishna²,

Kandasamy³

et al. 2013

JCDR

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Alveolar Soft Part Sarcoma (ASPS) is a very rare type of soft tissue sarcoma. Its cell of origin is unclear. It usually presents in the second to fourth decade of life. The most common reported sites of ASPS are the lower extremities, the head and the neck.Because of the rarity of this disease, there is no standard treatment plan. Surgical excision with negative margins is considered as the treatment of choice. We are reporting a rare presentation of ASPS as a male breast lump.

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Chemotherapy in alveolar soft part sarcomas

Cited by 112 publications

References 42 publications

Imaging features of primary and metastatic alveolar soft part sarcoma: single institute experience in 25 patients

Imaging features of primary and metastatic alveolar soft part sarcoma: single institute experience in 25 patients

Alveolar soft part sarcoma associated with lung and brain metastases: A case report

Alveolar Soft Part Sarcoma-A Histological Surprise in a Male Patient who was Suspected to have Breast Cancer

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