Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid plexus tumors

Wrede, Brigitte; Liu, Ping; Wolff, Johannes

doi:10.1007/s11060-007-9428-x

Cited by 134 publications

(106 citation statements)

References 36 publications

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“…As shown in Figure 1a, PDGF receptor a staining scores were high in 6 cases (27%); 3 cases displayed intermediate staining scores (5)(6)(7)(8), whereas low staining scores (0-4) were observed in 13 cases (59%). The proportion of tumors displaying high staining scores for PDGF receptor b was higher: 13 cases (59%) showed high staining scores for PDGF receptor b, whereas 6 cases displayed intermediate staining scores (5-8) and only 3 cases (14%) displayed low staining scores (0-4; Figure 1b).…”

Section: Pdgf Receptor Protein Expressionmentioning

confidence: 95%

“…1,2,4 Surgery remains the therapeutic mainstay, 3,5 but due to infiltrative growth and high vascularity of these tumors, gross total resection often cannot be achieved. Chemotherapy and cranial irradiation do improve survival, 6,7 but the latter is usually not an option in very young children. Therefore, development of novel therapeutic approaches would be desirable.…”

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confidence: 99%

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Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas

et al. 2008

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Platelet-derived growth factor (PDGF) receptor signaling has been implicated in the development of glial tumors, but not yet been examined in choroid plexus carcinomas, pediatric tumors with dismal prognosis for which novel treatment options would be desirable. Therefore, protein expression of PDGF receptors a and b as well as amplification status of the respective genes, PDGFRA and PDGFRB, were examined in a series of 22 patients harboring choroid plexus carcinoma using immunohistochemistry and chromogenic in situ hybridization (CISH). The majority of choroid plexus carcinomas expressed PDGF receptors with 6 cases (27%) displaying high staining scores for PDGF receptor a and 13 cases (59%) showing high staining scores for PDGF receptor b. Correspondingly, copy-number gains of PDGFRA were observed in 8 cases out of 12 cases available for CISH and 1 case displayed amplification (six or more signals per nucleus). The proportion of choroid plexus carcinomas with amplification of PDGFRB was even higher (5/12 cases). PDGFRB amplification status and PDGF receptor b protein expression scores were significantly correlated (P ¼ 0.01, Spearman). Expression status of PDGF receptor a or PDGF receptor b was not significantly associated with progressionfree survival. To conclude, expression and amplification of PDGF receptors, particularly PDGF receptor b, are frequent in choroid plexus carcinomas, providing a first rationale for the development of treatments targeting PDGF receptor signaling in these rare malignant pediatric tumors.

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Section: Pdgf Receptor Protein Expressionmentioning

confidence: 95%

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confidence: 99%

Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas

et al. 2008

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“…Several reports demonstrated that postoperative irradiation confers a survival advantage in patients who have undergone a subtotal resection as well as gross total resection [1,9,10,24,29]. Some authors recommend regional radiation [30] whereas others performed craniospinal radiation [11,24].…”

Section: Discussionmentioning

confidence: 99%

MGMT promoter methylation and temozolomide response in choroid plexus carcinoma

et al. 2011

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Choroid plexus carcinoma (CPC) is a malignant tumor with a strong tendency to spread along the cerebrospinal fluid pathway. There is no standardized chemotherapy protocol for this rare tumor. We report a 38-year-old man with CPC in the lateral ventricle with obstructive hydrocephalus. Because of the poor demarcation between thalamus and fornix, subtotal tumor resection was performed. Postoperative spine magnetic resonance (MR) image revealed whole spinal axis dissemination. After diagnosis of CPC, the patient was treated with whole ventricular and spine radiation concomitant with temozolomide chemotherapy, although the O 6 -methylguanine-DNA methyltransferase (MGMT) promoter was found to be unmethylated. Although MR images revealed transient stable disease during adjuvant therapy, tumor progression was depicted after four cycles of temozolomide therapy. We discuss the ineffectiveness of adjuvant temozolomide therapy for CPC in connection with O 6 -methylguanine-DNA methyltransferase promoter methylation.

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“…12) Prognostic improvement of CPC was reported with chemotherapy. 13) However, the efficacy of chemotherapy for ACPP is difficult to discuss because the data is too limited to analyze. Our patient underwent 4 cycles of chemotherapy using cyclophosphamide, vincristine, cisplatin, and etoposide, because the new lesion emerged adjacent to the brain stem.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Multi-staged Surgery and Adjuvant Chemotherapy for Successful Treatment of Atypical Choroid Plexus Papilloma in an Infant -Case Report-

Takahashi

Yamamoto

Aoyama

et al. 2009

Neurol. Med. Chir.(Tokyo)

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A 12-month-old girl presented with a rare atypical choroid plexus papilloma manifesting as conscious disturbance and vomiting. Magnetic resonance (MR) imaging revealed a well-delineated 5 × 6-cm lobulate mass in the right lateral ventricle. Only partial removal of the tumor was performed because of excessive intraoperative hemorrhage at the first surgery. The histological diagnosis was atypical choroid plexus papilloma. To control the intraoperative hemorrhage, embolization of the feeding artery was performed before the second surgery, and the tumor was macroscopically totally removed. MR imaging disclosed a small residual tumor which showed relatively rapid growth. The patient underwent the third removal 5 months after the second surgery. Two months later, MR imaging showed a cystic lesion with a small nodule adjacent to the midbrain, indicating dissemination of the tumor. The lesion was successfully treated with chemotherapy. Atypical choroid plexus papilloma was recently defined in the classification of the World Health Organization, so clinical data based on these criteria are lacking to establish the therapeutic strategy. Total resection of atypical choroid plexus papilloma is the most reliable treatment at present. However, postoperative chemotherapy should be considered for recurrence or dissemination.

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Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid plexus tumors

Abstract: Patients with less than completely resected CPC should receive chemotherapy.

Cited by 134 publications

References 36 publications

Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas

Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas

MGMT promoter methylation and temozolomide response in choroid plexus carcinoma

Efficacy of Multi-staged Surgery and Adjuvant Chemotherapy for Successful Treatment of Atypical Choroid Plexus Papilloma in an Infant -Case Report-

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