Chemotherapy for Staphylococcus Aureus in Burns

Lowbury, E. J. L.; Topley, Elizabeth; Hood, A. M.

doi:10.1016/s0140-6736(52)90693-4

Cited by 26 publications

(8 citation statements)

References 22 publications

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“…Penicillin-resistant Staph. aureus strains isolated from patients in hospital are most commonly found to belong to the 6/47 group (Barber & Whitehead, 1949;Lowbury, Topley & Hood, 1952). In this M.R.C.…”

Section: Discussionmentioning

confidence: 99%

The Acquired Resistance of Staphylococcus aureus to Bacteriophage

Lowbury

Hood

1953

Journal of General Microbiology

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SuMMaRY: To test the capacity of different staphylococci to YqUi re resistance to bacteriophage in &TO, twenty phages were grown on solid medium and in fluid medium with their propagating strains of Staphylococcus aureus, different phage types and patterns being represented.Resistant secondary growth never appeared among staphylococci of the 3 A group and often appeared among members of the 6/47 group. Some members of the 29/52 group acquired resistance readily, and others never became resistant, Cross-resistance to other phages was oornmonly acquired. Secondary growth was shown to be resistant or sensitive to the phage, or to yield a mixture of resistant and sensitive colonies.With the exception of propagating strain PS69, all staphylococci which became resistant to phage acquired lysogenicity for the sensitive parent strain. All but one of the staphylococci which had acquired resistance'to a phage appeared to be capable of absorbing that phage. A substance which caused non-specific inhibition of phage lysis on agar medium was present in phage lysates of a staphylococcus that had shown sensitive secondary growth. These results am discussed with reference to phage typing and to the possibilities of therapy by phage.

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Section: Discussionmentioning

confidence: 99%

The Acquired Resistance of Staphylococcus aureus to Bacteriophage

Lowbury

Hood

1953

Journal of General Microbiology

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“…The burns were swabbed at changes of dressings (usually every two or three days) and examined for Ps. aeruginosa and other bacteria as described elsewhere (Lowbury, 1960;Brown and Lowbury, 1965). Because of recent success in prophylaxis against Ps.…”

Section: Administration Of Carbeniciffin To Patients With Burnsmentioning

confidence: 99%

Prophylaxis and therapy for Pseudomonas aeruginosa infection with carbenicillin and with gentamicin.

Jones¹,

Lowbury²

1967

BMJ

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“…Many reports (Rountree & Thomson, 1952;Clarke, Dalgleish & Gillespie, 1952;Lowbury, Topley & Hood, 1952;Shooter et al 1958;Williams, 1959;and Barber et al 1960) have emphazised the dangerous nature of tetracycline resistant strains, their emergence and predominance in cases of hospital sepsis, and their ability to spread by cross-infection.…”

Section: Resultsmentioning

confidence: 99%

Mercury resistance and tetracycline resistance inStaphylococcus aureus

1967

J. Hyg.

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Minimum inhibitory concentrations of tetracycline to 256 tetracycline-resistant strains ofStaphylococcus aureuswere determined. M.I.C.'s tetracycline were appreciably higher among mercury resistant than among mercury sensitive strains.Mercury resistant strains representing various M.I.C.'s tetracycline grew significantly better in peptone water containing a therapeutic concentration of tetracycline than mercury sensitive strains representing the same range of resistance. The experiment was repeated after both groups had been adapted—or ‘trained’—to grow on agar containing tetracycline, 100µg./ml. The mercury sensitive strains now grew better than the mercury resistant group.The significance of these findings is discussed. It is concluded that tetracycline resistance is more stable and efficient in mercury resistant strains, and that it is probably genetic in origin—the result of mutation and selection. Tetracycline resistance in mercury sensitive strains is possibly the result of ‘training’.The associations and significance of both mercury resistance and tetracycline resistance inStaphylococcus aureusare discussed.

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Chemotherapy for Staphylococcus Aureus in Burns

Cited by 26 publications

References 22 publications

The Acquired Resistance of Staphylococcus aureus to Bacteriophage

The Acquired Resistance of Staphylococcus aureus to Bacteriophage

Prophylaxis and therapy for Pseudomonas aeruginosa infection with carbenicillin and with gentamicin.

Mercury resistance and tetracycline resistance inStaphylococcus aureus

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