Chemotherapy for Lung Cancer by Intra-aortic Infusion

Freckman, Herman A.

doi:10.1001/jama.1966.03100140059015

Cited by 10 publications

(2 citation statements)

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“…Die intraarterielle Chemoperfusion (IACP) ist ein seit Langem etabliertes Therapieverfahren bei der Behandlung von Lungentumoren. In der Anfangszeit wurde es hauptsächlich in einem palliativen Kontext verwendet, um die Effizienz zu verbessern und die Komplikationen durch die Applikation von Chemotherapeutika so nah wie möglich am Zieltumor zu verringern [37]. Die IACP wurde nicht nur bei der Behandlung von Lungentumoren, sondern auch anderen Tumorarten verwendet [38].…”

Section: Intraarterielle Chemoperfusion (Iacp)unclassified

“…Intraarterial chemoperfusion (IACP) is a long-established method for the treatment of lung tumors. In the beginning, it was mainly used in a palliative context to improve performance and to reduce complications by applying chemotherapeutic agents as close as possible to the target tumor [37]. IACP was used not only for the treatment of lung tumors but also for other types of tumors [38].…”

Section: Intraarterial Chemoperfusion (Iacp)mentioning

confidence: 99%

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Intravascular Treatment Techniques for Locoregional Therapies of Lung Tumors

Vogl

Mekkawy

Thabet

2023

Rofo

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Background Lung cancer incidence has greatly increased over the past century. Moreover, the lung is the most common site of metastatic involvement. Despite improvements in the diagnosis and treatment of lung malignancies, patient prognosis is still unsatisfactory. Locoregional chemotherapeutic techniques for the treatment of lung malignancies are the current focus of research. The aim of this review article is to present different locoregional intravascular techniques and their treatment principles and to assess the pros and cons of each of them as a palliative and neoadjuvant treatment method in the treatment of lung malignancy. Method The different methods for the treatment of malignant lung lesions such as isolated lung perfusion (ILP), selective pulmonary artery perfusion (SPAP), transpulmonary chemoembolization (TPCE), bronchial artery infusion (BAI), bronchioarterial chemoembolization (BACE), and intraarteriel chemoperfusion (IACP) are evaluated comparatively. Results Locoregional intravascular chemotherapy procedures are proving to be promising treatment options in the management of malignant lung tumors. In order to achieve optimal results, the locoregional technique should be used to achieve the highest possible uptake of the chemotherapeutic agent into the target tissue with rapid systemic clearance. Conclusion Among the various treatment options for lung malignancies, TPCE is the best evaluated treatment concept. However, further studies are necessary to define the optimal treatment concept with the best clinical outcomes. Key Points Citation Format

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Section: Intraarterielle Chemoperfusion (Iacp)unclassified

Section: Intraarterial Chemoperfusion (Iacp)mentioning

confidence: 99%

Intravascular Treatment Techniques for Locoregional Therapies of Lung Tumors

Vogl

Mekkawy

Thabet

2023

Rofo

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Bronchial artery perfusion for treatment of advanced lung cancer

Cliffton¹

1969

Cancer

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Twenty‐one patients with advanced lung cancer, limited to the chest, were treated by bronchial artery perfusion using 0.4 to 0.6 mg/kg of HN2 using a double lumen, double balloon aortic catheter. The infusion was made into the aorta between levels T4 and T8. Two patients were infused 2 times. There were no serious complications in these 21 patients. Average survival of the 21 treated patients was 8 months with a range from one day to 45 months. Symptoms were improved in the majority of treated patients. Cough was improved in 80%. Pain was completely relieved in 3, almost completely relieved in 2, and improved in 4–a total 9 of the 15 patients with severe, persistent pain. There was objective evidence of improvement in 12 patients. Five had objective measured improvement in pulmonary function and, in 7 of the 21 patients (32%), there was decrease in the size of the tumor mass as recorded on official x‐ray reports. Average survival in 6 patients considered for perfusion but not completed, because of technical difficulties, was 1.8 months with a range from 1 to 3 months.

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Chemotherapy of breast cancer by regional intra-arterial infusion

Freckman¹

1970

Cancer

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Over a 7‐year period (1961‐1968), 129 patients with metastatic breast cancer were treated by the continuous intra‐arterial infusion of selected antineoplastic agents into dominant regional tumor‐bearing areas utilizing a percutaneous needle technique for catheter placement. With few exceptions, all patients had received prior surgery and/or radiation therapy. Fifty‐four (41.8%) of the 129 patients obtained an objective response of from 6 to 49 months' duration, averaging 14.7 months with a mean survival time of 20.7 months as compared to 5.7 months for the nonresponders. Fluorouracil, cyclophosphamide, vinblastine, and methotrexate were the agents administered singly or in combination. Prednisolone (orally) was concurrently administered. A total of 410 infusions were administered with a major complication rate of 0.9% and a minor complication rate of 8.9%. This simplified procedure for intraarterial infusion chemotherapy has produced clinically significant results.

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Chemotherapy for Lung Cancer by Intra-aortic Infusion

Cited by 10 publications

References 0 publications

Intravascular Treatment Techniques for Locoregional Therapies of Lung Tumors

Intravascular Treatment Techniques for Locoregional Therapies of Lung Tumors

Bronchial artery perfusion for treatment of advanced lung cancer

Chemotherapy of breast cancer by regional intra-arterial infusion

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