Chemotherapy for Angiosarcoma of the Breast: Case Report of 30-Year Survival and Analysis of the Literature

Silverman, Lewis R.; Deligdisch, Liane; Mandeli, John; Greenspan, Ezra M.

doi:10.3109/07357909409024870

Cited by 44 publications

(22 citation statements)

References 24 publications

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“…In these 3 cases partial responses were seen after paclitaxel which let to successful surgery [5]. In one case report a 30-year remission in metastatic angiosarcoma is recorded following the use of methotrexate [6]. We could find any report relating to the use of Bevicizumab although the vascular endothelial growth factor may be overexpressed in breast angiosarcoma [7].…”

Section: Discussionmentioning

confidence: 86%

Complete Response of Radiation related Angiosarcoma of the Breast with CMF Chemotherapy

Vohra¹,

Siddiqui²

2017

Arch Can Res

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Angiosarcoma of breast or chest wall is a rare recognized side effect in breast cancer survivors secondary to Adjuvant radiation. The treatment of angiosarcoma of the breast is carried out in number of ways. We would like to report the case of a 50-year old woman. She developed an angiosarcoma of the breast following adjuvant radiation to her conserved breast and was successfully treated with classical Cyclophosphamide, Methotrexate, and 5-fluorouracil (CMF) chemotherapy leading to a successful local surgical salvage.

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Section: Discussionmentioning

confidence: 86%

Complete Response of Radiation related Angiosarcoma of the Breast with CMF Chemotherapy

Vohra¹,

Siddiqui²

2017

Arch Can Res

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“…La radioterapia adyuvante parece disminuir las recurrencias locales (20-50%) y ciertos quimioterápicos (Paclitaxel) (15,16) así como nuevos agentes (Bevacizumab, Rapamicina) (17,18) administrados de forma adyuvante muestran ciertos beneficios aplicados de forma individualizada.…”

Section: Discussionunclassified

Angiosarcoma primario de mama y carcinoma papilar de tiroides sincrónico: presentación de un caso

et al. 2013

Rev. chil. obstet. ginecol.

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RESUMENAntecedentes: El angiosarcoma primario de mama constituye un tumor infrecuente que se desarrolla de forma predominante en mujeres en la tercera y cuarta décadas de la vida. Los nódulos tiroideos incidentales son aquellos que se objetivan en pruebas de imagen realizadas por otra causa y se observan en menos de un 10% con la tomografía por emisión de positrones (PET). Objetivo: Presentar el caso excepcional de una paciente con angiosarcoma primario de mama y un carcinoma papilar de tiroides sincrónicos. Caso clínico: Mujer de 34 años con angiosarcoma primario en la mama derecha sometida a mastectomía simple. En el estudio de extensión se halló un incidentaloma tiroideo derecho compatible con carcinoma papilar que requirió tiroidectomía total y linfadenectomía del compartimento central cervical en un segundo tiempo. Comentario: Los angiosarcomas primarios suponen menos del 0,05% de todos los tumores primarios malignos de la mama. El diagnóstico definitivo de estos tumores viene definido por el estudio anatomopatológico, que establece tres grados: alto, bajo e intermedio, los cuales se relacionan de forma directa con la supervivencia. La prevalencia de los incidentalomas malignos tiroideos objetivados por PET varía del 14-30,9%, según diferentes estudios. La planificación del tratamiento quirúrgico de las neoplasias incidentales tiroideas en pacientes con otro tumor primario debe analizarse de forma individualizada, según la supervivencia esperada del tumor primario. PALABRAS CLAVE: Angiosarcoma primario mama, carcinoma papilar tiroides, nódulo incidental tiroideo SUMMARY Background:The primary angiosarcoma of breast is a rare tumor that develops predominantly in women in the third and fourth decades of life. Incidental thyroid nodules are observed in imaging tests performed for other reasons and it´s observed in less than 10% with the positron emission tomography (PET). Aims: To report the exceptional case of a patient with primary angiosarcoma of the breast and synchronous thyroid papillary carcinoma. Clinical case: Female patient 34 year old with primary angiosarcoma in the right breast, submitted to a simple mastectomy. In the extension study we found an incidental thyroid papillary carcinoma that required a total thyroidectomy and central cervical lymphadenectomy in a second time. Comments: The primary angiosarcoma are less than 0.05% of all primary malignant tumors of the breast. The definitive diagnosis is determined by the pathology, which defines three grades: high, low and intermediate, which relate directly to survival. Prevalence of malignant thyroid incidentalomas observed by PET varies from 14 to 30.9%, according different studies. Planning the surgical treatment of incidental thyroid malignancies in patients with other primary tumor should be analyzed individually, according the expected survival of the primary tumor.

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“…We support wide local excision as the best treatment, followed by adjuvant therapy (chemotherapy, radiation) if there are microscopically involved margins. Silverman et al [9] noted the statistical superiority of adjuvant chemotherapy to the more poorly differentiated tumors (29.2 vs. 4.4%; p < 0.05). In the present case, the patient received simple mastectomy of the right breast in 2005, and of the left breast in 2008.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Metachronous Bilateral Angiosarcoma of the Breast

Zhou

Wei²,

Ding³

2009

Breast Care

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Background: Primary angiosarcoma of the breast (PAB) is a rare occurrence of highly aggressive biological behavior. Bilateral PAB is even more infrequent. Case Report: We present the case of a 39-year-old Chinese woman with metachronous bilateral PAB (2005 and 2008). The diagnosis of PAB was confirmed. The respective masses were removed via simple mastectomy. The extent of malignancy differed microscopically between the two tumors and indicated a different source. After two surgeries and a 3-year follow-up, the patient is alive and well. The current case illustrates an unusual presentation of this rare type of breast sarcoma, in that none of the clinicopathological findings are thought to confer a good prognosis. We also review the literature and summarize relevant findings concerning definition, pathology, clinical features, treatment, and follow-up. Conclusions: We believe that the survival rate depends on tumor size and differentiation. Surgical resection followed by chemotherapy may prove to be effective and afford the best prognosis in the future.

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Chemotherapy for Angiosarcoma of the Breast: Case Report of 30-Year Survival and Analysis of the Literature

Cited by 44 publications

References 24 publications

Complete Response of Radiation related Angiosarcoma of the Breast with CMF Chemotherapy

Complete Response of Radiation related Angiosarcoma of the Breast with CMF Chemotherapy

Angiosarcoma primario de mama y carcinoma papilar de tiroides sincrónico: presentación de un caso

A Rare Case of Metachronous Bilateral Angiosarcoma of the Breast

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