Chemotherapy based on “Domino-effect” combined with immunotherapy amplifying the efficacy of an anti-metastatic treatment

Abstract

In tumor immunotherapy, Treg cells are immunosuppressive cells. Generally, the main strategies of chemo immune-therapy for Treg cells are to eliminate them by using chemotherapy drugs combined with immune checkpoint...

Engineered nanomaterials trigger abscopal effect in immunotherapy of metastatic cancers

“…Although depletion of Tregs throughout the body caused tumor cell regression, it also caused severe inflammation in the body ( Lui et al, 2020 ). In one study, a homemade curcumin analog (CA) was encapsulated in α-lactalbumin (α-LA), and the Treg cell-specific antibody (mAb), as a therapeutic agent, was linked to the drug-loaded protein via matrix metalloproteinase-responded peptide (P) to form CA@α-LA-P-mAb NPs ( Du et al, 2020 ). The diameter of CA@α-LA-P-mAb NPs were 175.0 ± 8.4 nm.…”

Tumor microenvironment-regulated drug delivery system combined with sonodynamic therapy for the synergistic treatment of breast cancer

“…[20][21][22] Therefore, the synthesis and development of nanodrug delivery systems (NDDS) with the abilities to modulate TME have become research hotspots in SDT. 23 Accordingly, herein, a pH-responsive TME-regulated NDDS, hollow mesoporous manganese dioxide (H-MnO 2 , HM) nanoshells, is established. HM can efficiently load both chemotherapeutic drugs and sonosensitizers.…”

“…20–22 Therefore, the synthesis and development of nanodrug delivery systems (NDDS) with the abilities to modulate TME have become research hotspots in SDT. 23…”

Engineering a facile and versatile nanoplatform to facilitate the delivery of multiple agents for targeted breast cancer chemo-immunotherapy

“…Recently, nanotechnology has attracted tremendous attention with diverse applications in medicine. Not only do nanoparticle-based platforms provide opportunities for combining different treatment strategies such as chemotherapy and immunotherapy, but also they are able to simultaneously deliver various payloads to the pre-determined regions with high selectivity [13][14][15]. Hyaluronic acid (HA) is an anionic glycosaminoglycan, which can be found in the extracellular matrix [16].…”