Chemotherapy and management of tuberculosis in the United Kingdom: recommendations 1998

Joint, T

doi:10.1136/thx.53.7.536

Cited by 406 publications

(10 citation statements)

References 69 publications

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“…Differentiating between TB DILI, ART-induced DILI and immune reconstitution inflammatory syndrome (IRIS) is challenging. [10][11][12] When comparing TB DILI patients on ART v. not on ART, we observed some interesting differences. Patients on ART tended to have a significantly longer duration of TBT at DILI diagnosis, lower ALT at DILI diagnosis, longer treatment interruption until rechallenge of TBT, smaller serial changes in ALT, and higher odds of receiving a modified TBT regimen.…”

Section: Discussionmentioning

confidence: 89%

Outcomes of TB/HIV co-infected patients presenting with antituberculosis drug-induced liver injury

et al. 2015

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Section: Discussionmentioning

confidence: 89%

Outcomes of TB/HIV co-infected patients presenting with antituberculosis drug-induced liver injury

et al. 2015

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“…National guidelines suggest treatment duration of 6 months, except in severe cases, where 9-12 months treatment regimens are applied, as also recommended by WHO [17]. This is in contrast to the recommendations applied in the United Kingdom and the United States, where all TBM patients are treated for 9-12 months [18,19]. A high proportion of the patients were treated with adjuvant prednisolone treatment; this is a well-established component of TBM treatment and has been shown to significantly reduce mortality rates [20].…”

Section: Discussionmentioning

confidence: 99%

Tuberculous meningitis in Denmark: a review of 50 cases

et al. 2011

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BackgroundTuberculous meningitis is the most severe manifestation of extrapulmonary tuberculosis with a high mortality rate and a high rate of sequelae among survivors. The aim of this study is to assess the current epidemiology, clinical features, diagnostic procedures, treatment and outcome in patients with tuberculous meningitis in Denmark, a country with a low tuberculosis incidence.MethodsA nationwide retrospective study was conducted, comprising all patients notified with tuberculous meningitis (TBM) in Denmark from 2000-2008. Medical records were reviewed using a standardised protocol.ResultsFifty patients, including 12 paediatric patients, were identified. 78% of the patients were immigrants from countries of high tuberculosis endemicity. 64% of all patients had a pre-existing immunosuppressive condition; 10% were HIV positive, 48% were HIV seronegative and 42% had an unknown HIV status. Median symptom duration before admission was 14 days in the Danish patient population and 20 days in the immigrant group. Biochemical analysis of cerebrospinal fluid (CSF) samples revealed pleocytosis in 90% with lymphocyte predominance in 66%. Protein levels were elevated in 86%. The most common findings on neuro-radiological imaging were basal meningeal enhancement, tuberculomas and hydrocephalus. Lumbar puncture was performed on 42 patients; 31 of these specimens (74%) had a positive CSF culture for mycobacteria and 9.5% were smear positive for acid-fast bacilli. The overall mortality rate was 19% and 48% of the remaining patients had neurological sequelae of varying degree.ConclusionTBM is a rare but severe manifestation of extrapulmonary TB in Denmark. The clinician must be prepared to treat empirically if the suspicion of TBM has arisen to improve treatment outcome.

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“…The diagnosis of rifampin monoresistance is also critical because this automatically invalidates the use of short-course chemotherapy ( 25 ). Of the 59 correctly identified rifampin-resistant MTBC isolates, 11 were rifampin monoresistant.…”

Section: Discussionmentioning

confidence: 99%