Chemotherapy Agents: A Primer for the Interventional Radiologist

Mihlon, Frank; Ray, Charles E.; Messersmith, Wells A.

doi:10.1055/s-0030-1267852

Cited by 26 publications

(24 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The response to chemotherapy in BC patients with evolution from 5 to 9 years and elevation of LDH and GGT enzymes were influenced by the W/Ins-Ins/Ins CBS genotype in this study; but it is well known that the response to chemotherapy depends on several factors. Adjuvant chemotherapy can induce persistent resistance to the drugs with longer exposure, and the anthracyclines have achieved longer time to progression and survival time compared with cyclophosphamide/methotrexate/5-fluorouracil-based chemotherapy [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

The association between the 844ins68 polymorphism in the CBS gene and breast cancer

Gallegos‐Arreola¹,

Figuera²,

Ramos-Silva³

et al. 2014

aoms

View full text Add to dashboard Cite

IntroductionThe cystathionine beta synthase (CBS) gene plays an important role in homocysteine metabolism because it catalyzes the first step of the transsulfuration pathway, during which homocysteine is converted to cystathionine. Polymorphisms of CBS have been associated with cancer.Material and methodsWe examined the role of the 844ins68 polymorphism by comparing the genotypes of 371 healthy Mexican women with the genotypes of 323 Mexican women with breast cancer (BC).ResultsThe observed genotype frequencies for controls and BC patients were 1% and 2% for Ins/Ins, 13% and 26% for W/Ins, and 86% and 72% for W/W, respectively. We found that the odds ratio (OR) was 2.2, with a 95% confidence interval (95% CI) of 1.5–3.3, p = 0.0001. The association was also evident when comparing the distribution of the W/Ins-Ins/Ins genotypes in patients in the following categories: 1) menopause and high γ-glutamyltransferase (GGT) levels (OR of 2.17, 95% CI: 1.17–4.26, p = 0.02), 2) chemotherapy response and high lactate dehydrogenase (LDH) levels (OR 2.2, 95% CI: 1.08–4.4, p = 0.027), 3) chemotherapy response and high GGT levels (OR 2.46, 95% CI: 1.2–4.8, p = 0.007), and 4) body mass index (BMI) and III–IV tumor stage (OR 3.2, 95% CI: 1.2–8.3, p = 0.013).ConclusionsWe conclude that the genotypes W/Ins-Ins/Ins of the 844ins68 polymorphism in the CBS gene contribute significantly to BC susceptibility in the analyzed sample from the Mexican population.

show abstract

Section: Discussionmentioning

confidence: 99%

The association between the 844ins68 polymorphism in the CBS gene and breast cancer

Gallegos‐Arreola¹,

Figuera²,

Ramos-Silva³

et al. 2014

aoms

View full text Add to dashboard Cite

show abstract

“…Lasting impairments to exercise tolerance are a direct physiological consequence of treatment, varying based on type of treatment and dose [157, 159, 165]. For example, intravenous chemotherapy and total body irradiation cause systemic inflammation and oxidative stress, which may damage vascular endothelial cells and skeletal muscle cells [156, 166, 167], impairing oxygen delivery and aerobic metabolism in skeletal muscles during activity [156, 167]. Anthracycline chemotherapies can cause lasting damage to cardiomyocytes, further limiting aerobic function via central mechanisms [168, 169].…”

Section: Cancermentioning

confidence: 99%

Physical activity for children with chronic disease; a narrative review and practical applications

et al. 2019

View full text Add to dashboard Cite

BackgroundPhysical activity (PA) is associated with a diverse range of health benefits. International guidelines suggest that children should be participating in a minimum of 60 min of moderate to vigorous intensity PA per day to achieve these benefits. However, current guidelines are intended for healthy children, and thus may not be applicable to children with a chronic disease. Specifically, the dose of PA and disease specific exercise considerations are not included in these guidelines, leaving such children with few, if any, evidence-based informed suggestions pertaining to PA. Thus, the purpose of this narrative review was to consider current literature in the area of exercise as medicine and provide practical applications for exercise in five prevalent pediatric chronic diseases: respiratory, congenital heart, metabolic, systemic inflammatory/autoimmune, and cancer.MethodsFor each disease, we present the pathophysiology of exercise intolerance, summarize the pediatric exercise intervention research, and provide PA suggestions. ResultsOverall, exercise intolerance is prevalent in pediatric chronic disease. PA is important and safe for most children with a chronic disease, however exercise prescription should involve the entire health care team to create an individualized program.ConclusionsFuture research, including a systematic review to create evidence-based guidelines, is needed to better understand the safety and efficacy of exercise among children with chronic disease.

show abstract

“…Second, many chemotherapeutic drugs target the microtubule network critical for segregating chromosomes during mitosis (Mihlon et al , ). These drugs disrupt microtubule dynamics either through hyperstabilizing (paclitaxel, docetaxel, and ixabepilone) or destabilizing (vincristine and vinblastine) microtubule formation.…”

Section: Introductionmentioning

confidence: 99%

Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases

2020

View full text Add to dashboard Cite

Chemotherapy is a life-saving treatment for cancer patients, but also causes long-term cognitive impairment, or "chemobrain", in survivors. However, several challenges, including imprecise diagnosis criteria, multiple confounding factors, and unclear and heterogeneous molecular mechanisms, impede effective investigation of preventions and treatments for chemobrain. With the rapid increase in the number of cancer survivors, chemobrain is an urgent but unmet clinical need. Here, we leverage the extensive knowledge in various fields of neuroscience to gain insights into the mechanisms for chemobrain. We start by outlining why the post-mitotic adult brain is particularly vulnerable to chemotherapy. Next, through drawing comparisons with normal aging, Alzheimer's disease, and traumatic brain injury, we identify universal cellular mechanisms that may underlie the cognitive deficits in chemobrain. We further identify existing neurological drugs targeting these cellular mechanisms that can be repurposed as treatments for chemobrain, some of which were already shown to be effective in animal models. Finally, we briefly describe future steps to further advance our understanding of chemobrain and facilitate the development of effective preventions and treatments.Cognitive complaints are common among cancer patients during and after chemotherapy. Cross-sectional and longitudinal studies suggest that short-term memory, working memory, and verbal ability are most frequently affected, followed by visuospatial memory, executive functions, and attention span (for meta-analyses, see

show abstract

Chemotherapy Agents: A Primer for the Interventional Radiologist

Cited by 26 publications

References 12 publications

The association between the 844ins68 polymorphism in the CBS gene and breast cancer

The association between the 844ins68 polymorphism in the CBS gene and breast cancer

Physical activity for children with chronic disease; a narrative review and practical applications

Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases

Contact Info

Product

Resources

About