Chemotherapy administered using two-route infusion of cisplatin and sodium thiosulfate and intravenous infusion of vinblastine and peplomycin in patients with oral cancer

Wada, Takuro; Harada, Masakazu; Morita, Nobuo; Oomata, Tetsuji; Koizumi, Taro; Kawashima, T.; Sakamoto, Tadayuki

doi:10.1016/0149-2918(95)80026-3

Cited by 8 publications

(5 citation statements)

References 10 publications

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“…Patients with OSCC, who underwent surgery in the Department of Oral and Maxillofacial Surgery of Wakayama Medical University, were treated with cisplatin‐based combination chemotherapy, including vinblastine and peplomycin, as neoadjuvant chemotherapy for 3 weeks 11. The criteria for a complete response (CR), partial response (PR) and no change (NC) were based on the standard definitions of the World Health Organization 12.…”

Section: Methodsmentioning

confidence: 99%

Identification of cisplatin‐resistance related genes in head and neck squamous cell carcinoma

Yamano

Uzawa

Saito

et al. 2009

Intl Journal of Cancer

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Resistance to cisplatin is a major obstacle to successful treatment of head and neck squamous cell carcinoma (HNSCC). To investigate the molecular mechanism of this resistance, we compared the gene expression profiles between the cisplatin‐sensitive SCC cell lines (Sa‐3, H‐1 and KB) and the cisplatin‐resistant cell lines established from them (Sa‐3R, H‐1R and KB‐R) using Affymetrix U133 Plus 2.0 microarray. We identified 199 genes differentially expressed in each group. To identify important functional networks and ontologies to cisplatin resistance, the 199 genes were analyzed using the Ingenuity Pathway Analysis Tool. Fifty‐one of these genes were mapped to genetic networks, and we validated the top‐10 upregulated genes by real‐time reverse transcriptase‐polymerase chain reaction. Five novel genes, LUM, PDE3B, PDGF‐C, NRG1 and PKD2, showed excellent concordance with the microarray data. In 48 patients with oral SCC (OSCC), positive immunohistochemical staining for the five genes correlated with chemoresistance to cisplatin‐based combination chemotherapy. In addition, the expression of the five genes predicted the patient outcomes with chemotherapy. Furthermore, siRNA‐directed suppressed expression of the five genes resulted in enhanced susceptibility to cisplatin‐mediated apoptosis. These results suggested that these five novel genes have great potential for predicting the efficacy of cisplatin‐based chemotherapy against OSCC. Global gene analysis of cisplatin‐resistant cell lines may provide new insights into the mechanisms underlying clinical cisplatin resistance and improve the efficacy of chemotherapy for human HNSCC.

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Section: Methodsmentioning

confidence: 99%

Identification of cisplatin‐resistance related genes in head and neck squamous cell carcinoma

Yamano

Uzawa

Saito

et al. 2009

Intl Journal of Cancer

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“…Oral squamous cell carcinoma patients, who underwent surgery in the Department of Oral and Maxillofacial Surgery of Wakayama Medical University, were treated with CDDP-based combination chemotherapy, including CDDP, vinblastine, and peplomycin, as neoadjuvant chemotherapy (Wada et al 1995). Briefly, in each patient, a catheter was inserted retrogradely into the superficial temporal artery and fixed where the primary tumors stained most intensely in a solution of indigocarmine.…”

Section: Patients and Clinical Specimensmentioning

confidence: 99%

Expression of caveolin-1 and its correlation with cisplatin sensitivity in oral squamous cell carcinoma

Nakatani

Wada

Nakamura

et al. 2005

J Cancer Res Clin Oncol

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“…Tables I through IV summarize the collective published experience with maxillary and sphenoid benign and malignant tumors according to histopathology and incidence. 7–50 , 51–100 , 101–150 , 151–200 , 201–250 , 251–300 , 301–350 , 351–400 , 401–450 , …”

Section: Resultsmentioning

confidence: 99%

Factors in the Pathogenesis of Tumors of the Sphenoid and Maxillary Sinuses: A Comparative Study

Reino

2000

The Laryngoscope

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Objectives/Hypothesis To explain the processes that lead to the development of tumors in the maxillary and sphenoid sinuses. Study Design A 32‐year review of the world's literature on neoplasms of these two sinuses and a randomized case‐controlled study comparing the normal mucosal architecture of the maxillary to the sphenoid sinus. Methods Analysis of a 32‐year world literature review reporting series of cases of maxillary and sphenoid sinus tumors. Tumors were classified by histological type and separated into subgroups if an individual incidence rate was reported. Histomorphometry of normal maxillary and sphenoid sinus mucosa was performed in 14 randomly selected patients (10 sphenoid and 4 maxillary specimens). Specimens were fixed in 10% formalin, embedded in paraffin, and stained with periodic acid–Schiff (PAS) and hematoxylin. Histomorphometric analysis was performed with a Zeiss Axioscope light microscope (Carl Zeiss Inc., Thornwood, NY) mounted with a Hamamatsu (Hamamatsu Photonics, Tokyo, Japan) color‐chilled 3 charge coupled device digital camera. The images were captured on a 17‐inch Sony (Sony Corp., Tokyo, Japan) multiscan monitor and analyzed with a Samba 4000 Image Analysis Program (Samba Corp., Los Angeles, CA). Five random areas were selected from strips of epithelium removed from each sinus, and goblet and basal cell measurements were made at magnifications ×100 and ×400. Results The literature review revealed that the number and variety of tumors in the maxillary sinus are much greater than those in the sphenoid. The incidence of metastatic lesions to each sinus is approximately equal. No recognized pattern of spread from any particular organ system could be determined. On histomorphometric study there were no statistically significant differences between the sinuses in the concentration of goblet cells, basal cells, or seromucinous glands. Conclusions Factors involved in the pathogenesis of tumors of the maxillary and sphenoid sinuses include differences in nasal physiology, embryology, morphology, and topography. There are no significant histological differences in the epithelium and submucous glands between the two sinuses to explain the dissimilar formation of neoplasms.

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Chemotherapy administered using two-route infusion of cisplatin and sodium thiosulfate and intravenous infusion of vinblastine and peplomycin in patients with oral cancer

Cited by 8 publications

References 10 publications

Identification of cisplatin‐resistance related genes in head and neck squamous cell carcinoma

Identification of cisplatin‐resistance related genes in head and neck squamous cell carcinoma

Expression of caveolin-1 and its correlation with cisplatin sensitivity in oral squamous cell carcinoma

Factors in the Pathogenesis of Tumors of the Sphenoid and Maxillary Sinuses: A Comparative Study

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