Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast cancer

Basudhar, Debashree; Cheng, Robert C.; Bharadwaj, Gaurav; Ridnour, Lisa A.; Wink, David A.; Miranda, Katrina M.

doi:10.1016/j.freeradbiomed.2015.01.029

Cited by 32 publications

(35 citation statements)

References 138 publications

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“…Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to suppress cell proliferation and carcinogenesis through different mechanisms. COX-dependent mechanisms of NSAID-suppression of breast cancer were demonstrated in human cell lines and in mice, when the inhibitory effect of NSAIDs was eliminated after genetic knockdown of COX-2 [ 174 ].…”

Section: Anti-inflammatory Drugs In Cancer Prevention and Treatmenmentioning

confidence: 99%

Role of COX-2/PGE2 Mediated Inflammation in Oral Squamous Cell Carcinoma

Nasry

Rodríguez-Lecompte

Martin

2018

Cancers

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A significant amount of research indicates that the cyclooxygenase/prostaglandin E2 (PGE2) pathway of inflammation contributes to the development and progression of a variety of cancers, including squamous cell carcinoma of the oral cavity and oropharynx (OSCC). Although there have been promising results from studies examining the utility of anti-inflammatory drugs in the treatment of OSCC, this strategy has been met with only variable success and these drugs are also associated with toxicities that make them inappropriate for some OSCC patients. Improved inflammation-targeting therapies require continued study of the mechanisms linking inflammation and progression of OSCC. In this review, a synopsis of OSCC biology will be provided, and recent insights into inflammation related mechanisms of OSCC pathobiology will be discussed. The roles of prostaglandin E2 and cluster of differentiation factor 147 (CD147) will be presented, and evidence for their interactions in OSCC will be explored. Through continued investigation into the protumourigenic pathways of OSCC, more treatment modalities targeting inflammation-related pathways can be designed with the hope of slowing tumour progression and improving patient prognosis in patients with this aggressive form of cancer.

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Section: Anti-inflammatory Drugs In Cancer Prevention and Treatmenmentioning

confidence: 99%

Role of COX-2/PGE2 Mediated Inflammation in Oral Squamous Cell Carcinoma

Nasry

Rodríguez-Lecompte

Martin

2018

Cancers

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“…IPA/NO-aspirin and DEA/NO-aspirin (Fig 3C) are two relatively new NONO-NSAIDs [249] with enhanced GI safety profiles, strong anti-inflammatory properties, and significant cytotoxcity compared to either aspirin or the parent diazeniumdiolate toward nonsmall cell lung carcinoma cells (A549) [250]. Both IPA/NO-aspirin and DEA/NO-aspirin were equally effective against hormone sensitive and insensitive breast cancer cell lines with no appreciable cytoxicity towards a related nontumorigenic cell line.…”

Section: Modulation Of No Levels As a Strategy To Treat Cancermentioning

confidence: 99%

The dichotomous role of H2S in cancer cell biology? Déjà vu all over again

Kashfi

2018

Biochemical Pharmacology

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Nitric oxide (NO) a gaseous free radical is one of the ten smallest molecules found in nature, while hydrogen sulfide (HS) is a gas that bears the pungent smell of rotten eggs. Both are toxic yet they are gasotransmitters of physiological relevance. There appears to be an uncanny resemblance between the general actions of these two gasotransmitters in health and disease. The role of NO and HS in cancer has been quite perplexing, as both tumor promotion and inflammatory activities as well as anti-tumor and antiinflammatory properties have been described. These paradoxes have been explained for both gasotransmitters in terms of each having a dual or biphasic effect that is dependent on the local flux of each gas. In this review/commentary, I have discussed the major roles of NO and HS in carcinogenesis, evaluating their dual nature, focusing on the enzymes that contribute to this paradox and evaluate the pros and cons of inhibiting or inducing each of these enzymes.

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“…Their disequilibrium has been associated with disease onset and progression in cancer, immune response and cardiovascular function among others [12–14]. In addition, the diverse pharmacology of nitroxyl (HNO), for example in treatment of heart failure, alcoholism and cancer [15–19], strongly suggests that HNO is likely biosynthesized.…”

Section: Introductionmentioning

confidence: 99%

Biological signaling by small inorganic molecules

Basudhar

Ridnour

Cheng

et al. 2016

Coordination Chemistry Reviews

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Small redox active molecules such as reactive nitrogen and oxygen species and hydrogen sulfide have emerged as important biological mediators that are involved in various physiological and pathophysiological processes. Advancement in understanding of cellular mechanisms that tightly regulate both generation and reactivity of these molecules is central to improved management of various disease states including cancer and cardiovascular dysfunction. Imbalance in the production of redox active molecules can lead to damage of critical cellular components such as cell membranes, proteins and DNA and thus may trigger the onset of disease. These small inorganic molecules react independently as well as in a concerted manner to mediate physiological responses. This review provides a general overview of the redox biology of these key molecules, their diverse chemistry relevant to physiological processes and their interrelated nature in cellular signaling.

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Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast cancer

Cited by 32 publications

References 138 publications

Role of COX-2/PGE2 Mediated Inflammation in Oral Squamous Cell Carcinoma

Role of COX-2/PGE2 Mediated Inflammation in Oral Squamous Cell Carcinoma

The dichotomous role of H2S in cancer cell biology? Déjà vu all over again

Biological signaling by small inorganic molecules

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