Chemotherapeutic and chemopreventive potentials of ρ-coumaric acid – Squid chitosan nanogel loaded with Syzygium aromaticum essential oil

Kamal, Islam; Khedr, Amgad I. M.; Alfaifi, Mohammad Y.; Elbehairi, Serag Eldin I.; Elshaarawy, Reda F.M.; Saad, Ahmed S.

doi:10.1016/j.ijbiomac.2021.08.038

Cited by 33 publications

(13 citation statements)

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“…In addition to this, it detailed the analytic methods that had been implemented in order to completely characterize the materials that had been obtained. The squid pens chitin, ultrasound-assisted deacetylated chitosan (UCS), and its low molecular-weight form (LMWUCS) were obtained from our previous work [ 25 ]. Moreover, the preparation of quaternized N-trimethyl chitosan chloride (TMC), from UCS, was depicted in the ESM† [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

“…The antioxidant activity of free VOO, OONE, TMCT, and OOHTN was evaluated using the 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (DPPH-RSA) technique reported by Kamal et al [25] with minor modifications. An aliquot of 0.5 mL of each sample solution of successive concentrations (5-320 µg/mL) was blended with an ethanolic DPPH solution (0.1 mM, 2.5 mL) in test tubes and then the mixtures were agitated and maintained in a dark area for 1 h at 25 • C. DPPH solution was employed as the standard for the experiment.…”

Section: Free Radical Scavenging Activity (Dpph Assay)mentioning

confidence: 99%

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Quaternized Chitosan Thiol Hydrogel-Thickened Nanoemulsion: A Multifunctional Platform for Upgrading the Topical Applications of Virgin Olive Oil

et al. 2022

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(1) Background: Virgin olive oil (VOO) has attracted the attention of many researchers due to its nutritional and medicinal values. However, VOO’s biological applications have been limited due to a lack of precise chemical profiling and approach to increase the physicochemical characteristics, bioactivity, and delivery of its bioactive components; (2) Methods: The current study intended to evaluate the chemical composition of VOO using the GC-MS technique and determine its major components. Furthermore, the effect of incorporating VOO into Tween 80-lecithin nanoemulsion (OONE) and a quaternized trimethyl chitosan-thiol (TMCT) hydrogel-thickened nanoemulsion system (OOHTN) on its physicochemical characteristics and biological potentials will be investigated; (3) Results: The VOO-based NEs’ physicochemical properties (particle size and zeta potential) were steady during storage for four weeks owing to the inclusion of the protective TMCT hydrogel network to OONE. Excessive fine-tuning of olive oil nanoemulsion (OONE) and the TMCT protective network’s persistent positive charge have contributed to the oil’s improved antimicrobial, anti-biofilm, and antioxidant potentials; (4) Conclusions: The Tween 80-lecithin-TMCT nanosystem might provide a unique and multifunctional nanoplatform for efficient topical therapy as well as the transdermal delivery of lipophilic bioactive compounds.

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Section: Methodsmentioning

confidence: 99%

Section: Free Radical Scavenging Activity (Dpph Assay)mentioning

confidence: 99%

Quaternized Chitosan Thiol Hydrogel-Thickened Nanoemulsion: A Multifunctional Platform for Upgrading the Topical Applications of Virgin Olive Oil

et al. 2022

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“…The specifications and suppliers of chemicals and solvents used in this work can be found in detail in the electronic Supplementary Material (ESM†). The squid pens chitin and ultrasound-assisted deacetylated chitosan (UCS) were obtained from the previous work [ 33 ].…”

Section: Methodsmentioning

confidence: 99%

Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol

et al. 2022

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Olives and virgin olive oil (VOO) are a staple of Mediterranean diets and are rich in several beneficial phenolic compounds, including hydroxytyrosol (HT). Therefore, VOO was extracted from Koroneiki olive fruits, and its volatile as well as phenolic components were identified. Meanwhile, in order to upgrade the pharmaceutical capabilities of VOO and HT, a new conjugate phenylboronic acid-chitosan nanoparticles (PBA-CSNPs, NF-1) was fabricated and applied as nanocapsules for implanting high loading and efficient delivery of VOO and HT nanoformulations (NF-2 and NF-3). Due to the H-bonding interactions and boronate ester formation between the hydroxyl groups of the phenolic content of VOO or HT and the PBA groups in the nanocapsules (NF-1), VOO and HT were successfully loaded into the PBA-CSNPs nanocapsules with high loading contents and encapsulation efficacies. The NF-2 and NF-3 nanoformulations demonstrated physicochemical stability, as revealed by their respective zeta potential values, and pH-triggered drug release characteristics. The in vitro studies demonstrated that the nascent nanocapsules were almost completely nontoxic to both healthy and cancer cells, whereas VOO-loaded (NF-2) and HT-loaded nanocapsules (NF-3) showed efficient anti-breast cancer efficiencies. In addition, the antimicrobial and antioxidant potentials of VOO and HT were significantly improved after nanoencapsulation.

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“…There, the antimicrobial activity was tested over Escherichia coli and Staphylococcus aureus , and in vitro anticancer activity was evaluated over the breast (MCF-7) and skin (A-375) cancer cell lines. It is worth noting that the reported results for those activities indicated higher values for the CS-pCA biomaterial than the essential oil [ 146 ]. A CS derivative, thiolated CS, has also been employed for the obtention of a pCA conjugate, showing an increased swelling capacity and mucoadhesion.…”

Section: Biomedical Applications Of Cs–hcas Conjugatesmentioning

confidence: 99%

Chitosan–Hydroxycinnamic Acids Conjugates: Emerging Biomaterials with Rising Applications in Biomedicine

Ojeda-Hernández

Canales-Aguirre²,

Matías‐Guiu

et al. 2022

IJMS

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Over the past thirty years, research has shown the huge potential of chitosan in biomedical applications such as drug delivery, tissue engineering and regeneration, cancer therapy, and antimicrobial treatments, among others. One of the major advantages of this interesting polysaccharide is its modifiability, which facilitates its use in tailor-made applications. In this way, the molecular structure of chitosan has been conjugated with multiple molecules to modify its mechanical, biological, or chemical properties. Here, we review the conjugation of chitosan with some bioactive molecules: hydroxycinnamic acids (HCAs); since these derivatives have been probed to enhance some of the biological effects of chitosan and to fine-tune its characteristics for its application in the biomedical field. First, the main characteristics of chitosan and HCAs are presented; then, the currently employed conjugation strategies between chitosan and HCAs are described; and, finally, the studied biomedical applications of these derivatives are discussed to present their limitations and advantages, which could lead to proximal therapeutic uses.

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Chemotherapeutic and chemopreventive potentials of ρ-coumaric acid – Squid chitosan nanogel loaded with Syzygium aromaticum essential oil

Cited by 33 publications

References 50 publications

Quaternized Chitosan Thiol Hydrogel-Thickened Nanoemulsion: A Multifunctional Platform for Upgrading the Topical Applications of Virgin Olive Oil

Quaternized Chitosan Thiol Hydrogel-Thickened Nanoemulsion: A Multifunctional Platform for Upgrading the Topical Applications of Virgin Olive Oil

Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol

Chitosan–Hydroxycinnamic Acids Conjugates: Emerging Biomaterials with Rising Applications in Biomedicine

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