Chemotaxonomy of the Ericales

Rocha, Marco Eduardo do Nascimento; Figueiredo, Maria Raquel; Kaplan, Maria Auxiliadora Coelho; Durst, Tony; Arnason, John T.

doi:10.1016/j.bse.2015.07.019

Cited by 8 publications

(2 citation statements)

References 24 publications

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“…Crockett and Robson 2011;Kinoshita 2014;Muangrom et al 2021;Muellner et al 2005;Tundis et al 2014) or at higher-level taxonomic groups (e.g. do Nascimento Rocha et al 2015;Jirschitzka et al 2012;Wink 2013).…”

Section: Introductionmentioning

confidence: 99%

Alkaloid diversification in the genus Palicourea (Rubiaceae: Palicoureeae) viewed from a (retro-)biogenetic perspective

et al. 2021

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The species-rich genus Palicourea (Rubiaceae: Palicoureeae) is source of an intriguing diversity of alkaloids derived from tryptamine and its precursor tryptophan. So far simple tryptamine analogues, polypyrroloindoline, β-carboline, and, most importantly, monoterpene-indole, i.e., tryptamine-iridoid alkaloids of various structural types including javaniside, alstrostine and strictosidine derivatives have been identified. Here the diverse alkaloids that numerous studies have found in the genus are examined and organized according to their structures and biosynthetic groups. Using a parsimony-based approach that follows the concept of retro-biogenesis usually applied in synthetic chemistry, possible biosynthetic pathways are proposed and important steps and relationships between these alkaloids are highlighted. Understanding alkaloid diversification is of importance in studying the ecological significance and evolution of biosynthetic capabilities of the genus Palicourea, and should stimulate future investigations on the biochemical and genetic background.

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Section: Introductionmentioning

confidence: 99%

Alkaloid diversification in the genus Palicourea (Rubiaceae: Palicoureeae) viewed from a (retro-)biogenetic perspective

et al. 2021

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“…This is a climbing shrub type that grows on the sandbanks of Rio de Janeiro, popularly known as “agarra-pé” (grab-foot) and is distributed in all Brazilian costal sandbanks from Paraíba State to Santa Catarina, and along the coast of Rio de Janeiro State [36,37]. The species is rich in flavonoids, considered chemosystematic markers for the Ericales order [38], and were detected in our samples by thin layer chromatography using specific reagents. Earlier, pharmacological tests were performed with this species in order to evaluate biodynamic potentials.…”

Section: Introductionmentioning

confidence: 99%

Antiviral and Immunomodulatory Effects of <b><i>Norantea brasiliensis</i></b> Choisy on Dengue Virus-2

Fialho

Silva²,

Reis³

et al. 2016

Intervirology

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Background/Aims: Severe dengue fever is a result of exacerbated immune responses and no specific treatments are available. We evaluated the antiviral and immunomodulatory effects of Norantea brasiliensis Choisy. Methods: Human adherent monocytes infected in vitro with dengue virus (DENV)-2 were incubated with the crude ethanol extract from leaves (NB1) or 3 derived fractions: dichloromethane (NB3), ethyl acetate (NB5), and butanolic (NB6) partitions. The antiviral and immunomodulatory activities were determined by intracellular detection of DENV antigen within monocytes and by secreted NS1 viral protein and cytokines. Results: The crude extract alone exhibited both antiviral activities (intracellular and secreted antigens) and all fractions derived from this extract modulated NS1 production. Regarding the immunomodulatory effect, among the secreted factors, TNF-α was inhibited by NB3 and NB6; IL-6 was inhibited by NB1, NB3, and NB6; IL-10 by NB1 and NB3; and IFN-α by NB6. The crude extract (NB1) presented the best antiviral effect, whereas the dichloromethane fraction (NB3) presented an immunomodulatory effect in the inflammatory and anti-inflammatory cytokines. Conclusion: During in vitro DENV infection, N. brasiliensis Choisy exerts both antiviral and immunomodulatory effects that are likely associated, considering that less viral load may lead to less immunostimulation.

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Chemosystematics micromolecular evolutionary trends relevant to the Urticaceae family

Maciel,

Ramos,

de Sousa

et al. 2023

Plant Syst Evol

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Chemotaxonomy of the Ericales

Cited by 8 publications

References 24 publications

Alkaloid diversification in the genus Palicourea (Rubiaceae: Palicoureeae) viewed from a (retro-)biogenetic perspective

Alkaloid diversification in the genus Palicourea (Rubiaceae: Palicoureeae) viewed from a (retro-)biogenetic perspective

Antiviral and Immunomodulatory Effects of <b><i>Norantea brasiliensis</i></b> Choisy on Dengue Virus-2

Chemosystematics micromolecular evolutionary trends relevant to the Urticaceae family

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