Chemotaxonomy of Agelas (Porifera: Demospongiae)

Abstract

Chemotaxonomy of the genus AgelasBraekman, J.C.; Stoller, C.; van Soest, R.W.M. Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Download date: 09 May 2018Biochemical Systernatics and Ecology, Vol. 20. No. 5. pp, 417-431, 1992 Abstract--The secondary metabolite content of four different species of Agelas (Porifera) from the West Indies has been studied. All the compounds isolated are already known metabolites whose identification was confirmed by comparison of their spectral properties with those reported in the literature. They pertain to two different classes of compounds: terpenoids and pyrrole-2-carboxylic acid derivatives. The chemotaxonomic value of these secondary metabolites has been evaluated. Their distribution amongst the Porifera, as well as that of isocyanide derivatives, suggests a close relationship between the Agelasidae, the Axinellidae and the Halichondriidae.

A secondary metabolite, 4,5-dibromopyrrole-2-carboxylic acid, from marine sponges of the genus Agelas alters cellular calcium signals

“…If such a deterrent comprises, beside its unpalatability to the fish, any pharmacological potency was only known in part for oroidin. Oroidin is also present within the tissues of A. clathrodes, A. cervicornis, A. dispar and A. wiedenmayeri (Braekman et al, 1992;Assmann et al, 1999Assmann et al, , 2000Lindel et al, 2000;Assmann et al, in press) and has previously been shown to be cytotoxic (König et al, 1998).…”

“…Especially sponges are known to be a rich font for interesting secondary metabolites, for example the genus Agelas (Agelasidae) is well known to contain a variety of bromopyrrole alkaloids (reviewed in Braekman et al, 1992;Lindel et al, 2000). Recently, detailed studies have shown both at laboratory and field conditions, that brominated pyrrole alkaloids like 4,5-dibromopyrrole-2-carboxylic acid were the principal fish antifeedant metabolites within the sponge tissue of Agelas sponges at natural concentrations (Pawlik et al, 1995;Chanas et al, 1996;Assmann et al, 2000Assmann et al, , 2004.…”

Alcalóides alquilpiridínicos de esponjas marinhas

“…As esponjas marinhas foram objeto de intensos estudos no que se refere à sua composição química e bioquímica, com vistas à utilização de metabólitos primários ou secundários como marcadores quimiotaxonômicos [17][18][19] . Isso se deve principalmente à escassez de caracteres anatômicos de fácil observação por métodos convencionais (microscopia óptica) em boa parte das espécies de Porifera, mas também devido à plasticidade morfológica de muitos destes caracteres e à inexistência, até recentemente, de métodos objetivos para o reconhecimento de determinados grupos de esponjas 8,[107][108][109] .…”

“…Considera-se que as esponjas foram os primeiros animais marinhos estudados do ponto de vista químico [11][12][13][14][15][16] . Estudos com produtos naturais de esponjas marinhas forneceram importantes informações do ponto de vista quimiotaxonômico [17][18][19][20] , ecológi-co [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] . Sem perder tempo, ele as corta vigorosamente com uma pequena foice.…”

“…Considera-se que as esponjas foram os primeiros animais marinhos estudados do ponto de vista químico [11][12][13][14][15][16] . Estudos com produtos naturais de esponjas marinhas forneceram importantes informações do ponto de vista quimiotaxonômico [17][18][19][20] , ecológi-co [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] , e sobre sua química e bioquímica 1,[38][39][40][41][42][43] . Porém, tendose em vista que diversas espécies de esponjas apresentam associações com cianobactérias e bactérias [44][45][46][47] , considera-se que vários produtos naturais isolados de esponjas possam ser originários de microorganismos 48 .…”