Chemotactic Factor associated with Invasion of Cancer Cells

Hayashi, Hideo; Yoshida, Keishiro; Ozaki, Teruhisa; Ushijima, Kenichiro

doi:10.1038/226174a0

Cited by 47 publications

(9 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These properties are mediated by a variety of different factors derived from tumor as well as normal tissues, including small proteolytic fragments of collagens, complement components, and extracellular matrix constituents [reviewed in [267]. Such factors stimulate directed motility of tumor cells in vivo to sites where they have been injected [268,269]. For example, Lamet al [270] injected i.p.…”

Section: Tumor Cell Chemotaxismentioning

confidence: 99%

Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites

1988

View full text Add to dashboard Cite

The locations of distant secondary tumors in many clinical cancers and animal tumors are nonrandom, and their distributions cannot be explained by simple anatomical or mechanical hypotheses based on the simple lodgment or trapping of tumor cell cmboli in the first capillary bed encountered. Evidence from certain experimental tumor systems supports Paget's 'seed and soil' hypothesis on the nonrandom distributions of metastases, in which the unique properties of particular tumor ceils ('seeds') and the different characteristics of each organ microenvironment ('soil') collectively determine the organ preference of metastasis. Experimentally, differential tumor cell adhesion to organ-derived microvessel endothelial cells and organ parenchymal cells, differential invasion of basement membranes and organ tissues, and differential responses to organ-derived growth-stimulatory and -inhibitory factors all appear to be important determinants in explaining the organ preference of metastasis. Each tumor system may achieve organ specificity because of its own unique set of multiple metastasis-associated properties and responses to host microenvironments. As neoplasms progress to more highly malignant states multisite metastases are more likely and organ-specific metastases may be masked or circumvented owing to stochastic events, tumor cell diversification, host selection processes, and increased production of tumor autocrine molecules that may modulate adhesion, invasion, growth, and other properties important in metastasis. The importance of each of these properties, however, appears to vary considerably among different metastatic tumor systems. These and other tumor cell and host properties may eventually be used to predict and explain the unique metastastic distributions of certain human malignancies.

show abstract

Section: Tumor Cell Chemotaxismentioning

confidence: 99%

Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites

1988

View full text Add to dashboard Cite

show abstract

“…At any rate, there is some experimental evidence that the in vivo localization of tumor cells can be influenced by chemotactic factors (45,46). A review on tumor cell chemotaxis was recently published by Varani and Ward (47).…”

Section: Basic Aspects Of Cell Motility and Tumor Invasionmentioning

confidence: 99%

The role of cancer cell motility in invasion

Sträuli

Haemmerli

1984

Cancer Metast Rev

View full text Add to dashboard Cite

“…), subsequent observations in animal hosts more clearly support the concept of a chemotactic localization of tumor cells. Chemotactic factors, isolated from fetal rat bone and tumors of human and animal origins, cause amassment of tumor cells at the intradermal injection sites (206,207). Following this initial finding, Ward and his associates discovered that tumors respond chemotactically to a fragment of the fifth component, a factor released from resorbing fetal rat bone and the synthetic tri-peptide Nformylmethionylleucylalanine (208)(209)(210)(211)(212)(213).…”

Section: Chemotactic Locomotionmentioning

confidence: 99%

Tumor invasion and host extracellular matrix

et al. 1983

View full text Add to dashboard Cite

In this review some of the major mechanistic pathways by which tumor cells are thought to invade host tissues are discussed. Tumor invasion has been conceived to be the result of pathological, close-range interactions between malignant cells and host stroma. The sequence of events that characterize invasion can be summarized as follows: (a) Tumor cell clusters break from the confinement of the primary tumor. Loss of intercellular junctions (desmosomes), alterations in the chemical composition and physical properties of the cell surface coat (loss of fibronectin and heparan sulfate; excessive amounts of hyaluronate), and loosening of cell-substrate interactions (loss of hemidesmosomes, fibronectin, and heparan sulfate), are among the most frequently listed causes of tumor cell shedding. (b) Increased proteolytic activities at the invasion front cause focal alterations in the surrounding extracellular matrix, thereby changing its physical properties. Collagenases and cathepsins, as well as elastase and other neutral proteinases are the enzymes most frequently associated with matrix destruction and invasion. In some tissues this process is effectively regulated by inhibitors of matrix-degrading, proteolytic enzymes. (c) Tumor cells migrate into the altered matrix, possibly moving as aggregates along guidance tracks provided by host structures (blood vessels, lymphatics, nerves) or matrix macromolecules (collagen and fibronectin tracks). Migration seems to be preceded by increased swelling of glycosaminoglycan (i.e., hyaluronate) in the matrix, ahead of the migrating cell population. Various host cell types (mast cells, fibroblasts, endothelial cells, macrophages, etc.) may participate in these events.

show abstract

Chemotactic Factor associated with Invasion of Cancer Cells

Cited by 47 publications

References 11 publications

Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites

Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites

The role of cancer cell motility in invasion

Tumor invasion and host extracellular matrix

Contact Info

Product

Resources

About