Chemotactic Cytokine Receptor 5 Genetic Polymorphism in Diabetic Nephropathy of the Type 2 Diabetes Mellitus

Abstract

Background and Aim: The inflammatory process can be involved in the pathophysiology of diabetic nephropathy (DN). One of the cytokine receptors in the inflammatory process is Chemotactic Cytokine Receptor 5 (CCR5), whose genetic variation can affect the incidence of DN in several populations in the world. This study aims to determine the proportion of CCR5 gene polymorphisms with DN in type 2 diabetes mellitus patients in Bali. Method: This study used a case-control design in 144 DNA samples of patients with type 2 diabetes mellitus. They were examined for the polymorphisms of the CCR5 gene by PCR-RFLP and then analyzed using Chi-Square statistical test. The p value <0.05 was significant. Results: The proportion of males more than females in subjects with diabetic nephropathy (p = 0.000). Duration of diabetes and systolic blood pressure were higher in subjects with diabetic nephropathy (p = 0.002; p = 0.002) respectively. The polymorphisms of the CCR5 gene did not differ significantly in subjects with and without diabetic nephropathy (p = 0.224). Conclusions: Gender, systolic blood pressure and duration of diabetes were associated with diabetic nephropathy, while CCR5 gene polymorphisms were not significantly associated with diabetic nephropathy in type 2 diabetes mellitus patients in Bali.