Chemosurgery for the microscopically controlled excision of skin cancer

Abstract

Chemosurgery is a method by which cutaneous cancers can be excised under complete microscopic control by the systematic use of frozen sections. The technique consists of three main steps: (1) application of a zinc chloride fixative paste, (2) excision of a layer of fixed tissue, and (3) systematic microscopic scanning of frozen sections cut through the undersurface of the specimens. The procedure is repeated in the cancerous areas until a completely cancer‐free plane is reached. Advantages of the method are unprecedented reliability, conservatism, low operative mortality, excellent healing, and the fact that it extends operability to many patients with cancers too extensive for hope of cure by other methods. Special training is essential for optimal results. Though the method is used by over 50 physicians, more should be trained so that chemosurgery is available in every large population center.

Treatment of Facial Basal Cell Carcinoma: A Review

“…Mohs micrographic surgery (MMS) was first reported by an American physician and general surgeon, Dr. Mohs, in 1941 [21]. Excised tissue is frozen and sectioned horizontally.…”

Unusual Auricular Complications in Cutaneous Oncology

“…ported. 1,4,5,8,14 Dermatol Surg Oncol 25,1988). The diagnosis of radiochondronecrosis should be considered when erythema, edema, and warmth suggestive of cellulitis overlie previously irradiated cartilage.…”

The Use of a Curved Ophthalmic Blade to Facilitate Incising Mohs Micrographic Sections with the Desired Bevel despite Anatomic Obstructions

“…In the late 1930s, Dr. Frederic Mohs began excising tumors uniquely, by analyzing 100% of the surgical margin 1 . The surgery is normally performed by incising the specimen with a bevel at 45 degrees 2–7 .…”