Chemosensory function before and after multimodal treatment in chronic rhinosinusitis patients

Walliczek‐Dworschak, Ute; Pellegrino, Robert; Taube, Franziska; Mueller, Christian A.; Stuck, Boris A.; Dworschak, Philipp; Güldner, Christian; Steinbach, Silke

doi:10.1002/lary.26873

Cited by 17 publications

(44 citation statements)

References 43 publications

(64 reference statements)

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“…After close evaluation of the publications, 24 studies reached the inclusion criteria for this review. These have been published over the last 20 years and used the USPIT or single components or the whole battery of the Sniffin’ Sticks test . Almost all the included studies were published in the period from 2007 to 2018; only one earlier study from 1994 was identified …”

Section: Resultsmentioning

confidence: 99%

“…Six studies used the 40‐item UPSIT . Two studies used a combination of at least two (sub‐) tests (I and T), and seven trials used the whole TDI‐score of the Sniffin' Sticks Set …”

Section: Resultsmentioning

confidence: 99%

“…It was obvious that the more sophisticated the olfactory test (e.g., T, D, and I), the higher the percentage of impairment, which indicates that screening tests usually underestimate the grade of olfactory dysfunction. Those studies that used more than one modality showed impairment rates from 72% to 100% …”

Section: Resultsmentioning

confidence: 99%

“…In the 24 studies, 959 patients with nasal polyps and 516 without nasal polyps were described. Eight studies included patients with CRSwNP only 27,28,30,31,33,34,42,48 ; 13 studies included CRSwNP and CRSsNP patients 29,[35][36][37][38][39][40][43][44][45][46][47]49 ; and three studies with 481 patients did not comment on the patients' polyp status. 25,26,41 Testing Methods…”

Section: Number Of Study Participantsmentioning

confidence: 99%

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Recovery of olfaction after sinus surgery for chronic rhinosinusitis: A review

Haxel

2019

The Laryngoscope

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Objective Investigation of the postoperative olfactory function after sinus surgery for chronic rhinosinusitis (CRS) with and without polyps in a review. Data Sources PubMed. Review Methods A comprehensive literature search was conducted through June 2018 using relevant keywords. The titles/abstracts were reviewed to identify studies evaluating the sense of smell in CRS‐patients pre‐ and postoperatively by either using the whole or parts of the University of Pennsylvania Smell Identification Test or the Sniffin’ Sticks test. Study characteristics and outcome data of the included studies were extracted. Results In total, 106 studies were retrieved. Twenty‐four studies comprising 1,956 patients were included after quality assessment. The number of patients investigated per study was 19 to 206. In the 24 studies, 959 patients with nasal polyps and 516 without nasal polyps were described. The follow‐up times varied between 0.5 and 28 months. Twenty‐three studies reported an improved sense of smell, at least in certain subgroups. An overall improvement was seen in approximately 50% of the included patients. Nasal polyposis and preoperative anosmia were associated with a higher chance of improvement in olfaction. In those studies that commented on deterioration after sinus surgery, a decrease in olfaction was found in a range from 0% to 10% of cases. Conclusion Olfaction can be improved by sinus surgery in about every second patient, especially if the patient had chronic rhinosinusitis with polyps, was anosmic, and had no prior surgery. A deterioration of sense of smell after surgery is rare. Laryngoscope, 129:1053–1059, 2019

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Section: Resultsmentioning

confidence: 99%

“…Six studies used the 40‐item UPSIT . Two studies used a combination of at least two (sub‐) tests (I and T), and seven trials used the whole TDI‐score of the Sniffin' Sticks Set …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Number Of Study Participantsmentioning

confidence: 99%

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Recovery of olfaction after sinus surgery for chronic rhinosinusitis: A review

Haxel

2019

The Laryngoscope

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“…Impaired olfaction is one of the cardinal symptoms of CRS and can be found in 30% to 78.2% of patients, varying somewhat by age, gender, and presence of polyps . Medications, primarily in the form of oral or topical corticosteroids, have been shown to provide demonstrable improvement in olfaction . Similarly, numerous studies have confirmed significant improvement in olfactory function after sinus surgery .…”

mentioning

confidence: 99%

Correlation of mucus inflammatory proteins and olfaction in chronic rhinosinusitis

Soler

Yoo

Schlosser

et al. 2019

Int Forum Allergy Rhinol

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Background Chronic rhinosinusitis (CRS) is one of the most common causes of olfactory loss, but the pathophysiology underlying olfactory dysfunction in CRS has not been fully elucidated. Previous studies found correlations between olfactory cleft (OC) inflammatory cytokines/chemokines and olfaction in CRS. The purpose of this study was to evaluate the relationship between OC mucus inflammatory proteins and olfaction in a multi‐institutional cohort. Methods Adults with CRS were prospectively recruited. Demographics, comorbidities, olfactory assessment (Sniffin’ Sticks), computed tomography (CT), and OC mucus for protein analysis were collected. Statistical analysis was performed to determine associations between olfactory function, OC mucus protein concentrations, and CT opacification. Results Sixty‐two patients were enrolled in the study, with an average age of 48.2 (standard deviation, 16.2) years, and 56.5% were female and 59.7% were classified as CRS with nasal polyps (CRSwNP). Ten of 26 OC mucus proteins were significantly correlated with threshold, discrimination, and identification (TDI) scores and OC opacification. Subgroup analysis by polyp status revealed that, within the CRSwNP group, C‐C motif ligand 2 (CCL2), interleukin‐5 (IL‐5), IL‐6, IL‐13, IL‐10, IL‐9, tumor necrosis factor‐α (TNF‐α), CCL5, and CCL11 were significantly correlated with olfaction. For CRS without nasal polyps (CRSsNP), only C‐X‐C ligand 5 (CXCL5) showed a correlation. In CRSwNP, IL‐6, IL‐10, vascular endothelial growth factor‐A, and immunoglobulin E (IgE) correlated with OC opacification, whereas, in CRSsNP, only CXCL5 showed a correlation. OC mucus proteins and Lund‐Mackay score correlated only in the CRSsNP group (CXCL5, IL‐5, IL‐13, IgE). Conclusion Several OC mucus proteins have been found to correlate with olfactory function and OC opacification. The profile of OC mucus proteins differs between CRSsNP and CRSwNP subgroups, suggesting different mechanisms between groups, but further study is required.

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International consensus statement on allergy and rhinology: Olfaction

Patel

Holbrook

Turner

et al. 2022

Int Forum Allergy Rhinol

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Background:The literature regarding clinical olfaction, olfactory loss, and olfactory dysfunction has expanded rapidly over the past two decades, with an exponential rise in the past year. There is substantial variability in the quality of this literature and a need to consolidate and critically review the evidence. It is with that aim that we have gathered experts from around the world to produce this International Consensus on Allergy and Rhinology: Olfaction (ICAR:O). Methods: Using previously described methodology, specific topics were developed relating to olfaction. Each topic was assigned a literature review, evidence-based review, or evidence-based review with recommendations format as dictated by available evidence and scope within the ICAR:O document. Following iterative reviews of each topic, the ICAR:O document was integrated and reviewed by all authors for final consensus. Results:The ICAR:O document reviews nearly 100 separate topics within the realm of olfaction, including diagnosis, epidemiology, disease burden, diagnosis, testing, etiology, treatment, and associated pathologies. Conclusion:This critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further.

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Chemosensory function before and after multimodal treatment in chronic rhinosinusitis patients

Abstract: 4. Laryngoscope, 128:E86-E90, 2018.

Cited by 17 publications

References 43 publications

Recovery of olfaction after sinus surgery for chronic rhinosinusitis: A review

Recovery of olfaction after sinus surgery for chronic rhinosinusitis: A review

Correlation of mucus inflammatory proteins and olfaction in chronic rhinosinusitis

International consensus statement on allergy and rhinology: Olfaction

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