Chemosensitizing indomethacin-conjugated chitosan oligosaccharide nanoparticles for tumor-targeted drug delivery

Lee, Jae-Young; Termsarasab, Ubonvan; Lee, Mee Yeon; Kim, Dong Hwan; Lee, Song Yi; Kim, Jung Sun; Cho, Hyun‐Jong; Kim, Dae‐Duk

doi:10.1016/j.actbio.2017.05.012

Cited by 53 publications

(38 citation statements)

References 36 publications

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“…The increased ROS resulted in stimulated intracellular and extracellular superoxide formation and was responsible for oxidative stress [15]. Heat stress generates ROS, which may modulate the inflammatory transcription factor nuclear factor-κB [16], inducing hormonal and metabolic changes, secretion of inflammatory cytokines [17], and decrease the level of antioxidant enzymes [17]. Former studies demonstrated that the pro-inflammatory cytokines level will increase under heat stress [13,14,18].…”

Section: Introductionmentioning

confidence: 99%

Chitosan Oligosaccharides Protect Sprague Dawley Rats from Cyclic Heat Stress by Attenuation of Oxidative and Inflammation Stress

Lan

Chang

et al. 2019

Animals

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Chitosan oligosaccharides (COS) exhibits antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the effects of COS on antioxidant system and inflammatory response in heat-stressed rats. A total of 30 male rats were randomly divided to three groups and reared at either 24 °C or 35 °C for 4 h/d for this 7-day experiment: CON, control group with basal diet; HS, heat stress group with basal diet; HSC, heat stress with 200mg/kg COS supplementation. Compared with the CON group, HS significantly decreased (p < 0.05) average daily gain (ADG); average daily feed intake (ADFI); the relative weight of spleen and kidney; the level of liver CAT, GSH-Px, T-AOC, and IL-10; spleen SOD, GSH-Px, GSH, and IL-10; and kidney SOD, GSH-Px, T-AOC, and IL-10, while significantly increased the MDA concentration in liver, spleen, and kidney; the liver IL-1β concentration; and spleen and kidney IL-6 and TNF-α concentration. In addition, dietary COS supplementation significantly improved (p < 0.05) ADG; the relative weight of spleen and kidney; the level of liver GSH-Px, spleen GSH-Px, GSH, and IL-10; and kidney GSH-Px, while significantly decreased (p < 0.05) liver IL-1β concentration under heat stress condition. Collectively, COS was beneficial to heat-stressed rats by alleviating oxidative damage and inflammatory response.

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Section: Introductionmentioning

confidence: 99%

Chitosan Oligosaccharides Protect Sprague Dawley Rats from Cyclic Heat Stress by Attenuation of Oxidative and Inflammation Stress

Lan

Chang

et al. 2019

Animals

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“…Qext =Qsca +Qabs or σext =σsca +σabs (2) When the intensity of the absorbed light decreased, the intensity of the scattered light increased. Since the scattering and absorption were at the same frequency, part of the absorbed energy was scattered due to resonance, which resulted in enhanced scattered light.…”

Section: =mentioning

confidence: 99%

“…The combined processes of absorbing and scattering light are referred to as light extinction [46]. According to the law of conservation of energy: Q ext = Q sca + Q abs or σ ext = σ sca + σ abs (2) When the intensity of the absorbed light decreased, the intensity of the scattered light increased. Since the scattering and absorption were at the same frequency, part of the absorbed energy was scattered due to resonance, which resulted in enhanced scattered light.…”

Section: Enhancement Of Hydrophobicitymentioning

confidence: 99%

“…The degraded products of chitosan or chitin, chito-oligosaccharides (COS) is a kind of low molecular weight oligosaccharide with good water solubility, high bioactivity and easy to be absorbed by human body because of shorter chain lengths and free amino groups in D-glucosamine units [1]. COS captured much attention from researchers on account of its good dissolvability [2] and a higher degree of deacetylation [3]. To our knowledge, COS has been proven to not only have antioxidant activity [4], and antimicrobial activity [5] but also have anti-tumor activity [6,7] and anti-inflammatory properties [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Application of Gelatin Decorated with Allura Red as Resonance Rayleigh Scattering Sensor to Detect Chito-Oligosaccharides

Zou

Sun

et al. 2020

Marine Drugs

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A convenient and sensitive triple-wavelength overlapping resonance Rayleigh scattering (TWO-RRS) method for the detection of chito-oligosaccharides (COS) was proposed based on enhancing the rigid surface of porous reticular spatial structure of gelatin and COS by introducing allura red AC (AR). The interaction and resultant porous reticular spatial structure were characterized with transmission electron microscopy (TEM), RRS, and UV-Vis spectroscopy. The results indicated that gelatin and COS formed porous reticular spatial structure with an average diameter of 1.5–2.0 μm, and the RRS value of COS-AR-gelatin ternary system with gelatin participation was significantly higher than that of COS-AR binary system. Under the optimal conditions, the enhanced TWO-RRS intensity of the system was linearly proportional to COS concentration in the range of 0.30–2.50 μg/mL, and the regression equation was ΔI = 4933.2c − 446.21 with R2 = 0.9980. The limit of detection was 0.0478 μg/mL. So, a new method for the detection of COS was established and verified in the health products with satisfactory results.

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“…Chitosan amphiphiles have been prepared by grafting hydrophilic and hydrophobic moieties onto the sugar backbone (J.‐Y. Lee, Termsarasab, et al, ). Both the amine and/or the hydroxyl groups can be used to functionalize chitosan (Sahariah & Másson, ).…”

Section: Polysaccharidesmentioning

confidence: 99%

Carbohydrate‐based nanomaterials for biomedical applications

Gim

Zhu

Seeberger

et al. 2019

WIREs Nanomed Nanobiotechnol

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Carbohydrates are abundant biomolecules, with a strong tendency to form supramolecular networks. A host of carbohydrate-based nanomaterials have been exploited for biomedical applications. These structures are based on simple monoor disaccharides, as well as on complex, polymeric systems. Chemical modifications serve to tune the shapes and properties of these materials. In particular, carbohydrate-based nanoparticles and nanogels were used for drug delivery, imaging, and tissue engineering applications. Due to the reversible nature of the assembly, often based on a combination of hydrogen bonding and hydrophobic interactions, carbohydrate-based materials are valuable substrates for the creations of responsive systems. Herein, we review the current research on carbohydratebased nanomaterials, with a particular focus on carbohydrate assembly. We will discuss how these systems are formed and how their properties are tuned. Particular emphasis will be placed on the use of carbohydrates for biomedical applications.

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Chemosensitizing indomethacin-conjugated chitosan oligosaccharide nanoparticles for tumor-targeted drug delivery

Cited by 53 publications

References 36 publications

Chitosan Oligosaccharides Protect Sprague Dawley Rats from Cyclic Heat Stress by Attenuation of Oxidative and Inflammation Stress

Chitosan Oligosaccharides Protect Sprague Dawley Rats from Cyclic Heat Stress by Attenuation of Oxidative and Inflammation Stress

Application of Gelatin Decorated with Allura Red as Resonance Rayleigh Scattering Sensor to Detect Chito-Oligosaccharides

Carbohydrate‐based nanomaterials for biomedical applications

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