Chemosensitivity to HM90822, a novel synthetic IAP antagonist, is determined by p-AKT-inducible XIAP phosphorylation in human pancreatic cancer cells

Hong, Seung-Woo; Shin, Jae‐Sik; Moon, Jai‐Hee; Koh, Dong-In; Ryu, Yeaseong; Park, Yoon Sun; Kim, Do Yeon; Park, Sangsoo; Hong, Jun; Kim, Eun Ho; Kim, Mi Jin; Jeong, Hong-Rae; Bae, In Hwan; Ahn, Young‐Gil; Suh, Kwee Hyun; Cho, Ig-Jun; Kang, Jong Soon; Hong, Yong Sang; Lee, Jung Shin; Jin, Dayong; Kim, Tae Won

doi:10.1007/s10637-020-00956-9

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…On the other hand, XIAP regulation appears to be executed through post-translational modifications, particularly proteasome-mediated degradation. Notably, XIAP can be phosphorylated by Akt and protein kinase C (PKC), which prevents its ubiquitination and subsequent proteasomal degradation ( 54 , 55 ). XIAP is also well-known for its E3 ubiquitin ligase activity, allowing it to induce autoubiquitination.…”

Section: Discussionmentioning

confidence: 99%

Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma

Kim,

Ahn,

Shin

et al. 2023

Oncol Rep

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Hypopharyngeal squamous cell carcinoma (HSCC) is a relatively rare form of head and neck cancer that is notorious for its poor prognosis and low overall survival rate. This highlights the need for new therapeutic options for this malignancy. The objective of the present study was to examine the ability of caffeic acid phenethyl ester (CAPE), which is an active compound found in propolis, to combat HSCC tumor growth. CAPE exerted its tumor-suppressive activity in HSCC cell lines through the induction of apoptosis. Mechanistically, the CAPE-mediated apoptotic process was attributed to the perturbation of the mitochondrial membrane potential and the activation of caspase-9. CAPE also modulated survivin and X-linked inhibitor of apoptosis, which are potent members of the inhibitors of apoptosis protein family, either through transcriptional or post-translational regulation, leading to HSCC cell line death. Therefore, the findings of the present study suggested that CAPE is an effective treatment alternative for HSCC via the stimulation of mitochondria-dependent apoptosis.

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Section: Discussionmentioning

confidence: 99%