“…Broth assays were performed to determine MICs of compounds (Table 10, 9b-f, h, l-m, q, u-v, z showed an MIC of 0.49 µg/mL against at least one organism, significantly better than the tetramate ester analogues 8a-g, 12 highlighting the importance of a carboxamide side chain group for whole-cell antibacterial activity. However, the presence of more polar carboxamides at C-7 led to a loss of activity (see 9d' and 9e').…”