Chemoresistive sensors for colorectal cancer preventive screening through fecal odor: Double-blind approach

Nanostructured SmFeO3 Gas Sensors: Investigation of the Gas Sensing Performance Reproducibility for Colorectal Cancer Screening

“…Nowadays, the market for solid-state gas sensors is constantly growing, as they are used in a wide variety of applications, including indoor and outdoor air quality monitoring, medical screening and precision farming [ 1 , 2 , 3 , 4 ]. Solid-state gas sensors are divided in four different broad categories, i.e., chemoresistive, optical, electrochemical gas sensors and quartz microbalance [ 5 ].…”

Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples

“…This depends on the fact that smaller and less aggressive tumors emanate smaller quantities of different metabolites and VOCs when compared to more aggressive or bigger neoplasms, as was proven in both the histological exam (which confirmed the different size and aggressiveness of the tumoral formations) and by comparison with ST25 650+Au, which instead could distinguish them as the less polluting cancers for the circulatory system by their mere observed responses. This is a huge confirmation of the work carried out on these particular sensors, since those materials were explicitly chosen from the assessments that the team could finalize from previous works [1][2][3][4][5][6][7], sealing the reliability of some semiconductors for neoplasms screening in vitro applications.…”

“…Our team is now gathering further data, from different cell types and tumor affected patients also, to increase the statistic pool and try PCA and machine learning approaches (as already carried out in previous studies [6,7]) on these new kinds of neoplasm, in order to visualize better defined patterns and program recognition algorithms from the resulting analysis. This comes with the following goals:…”

“…The variety of sensors chosen lays upon the will to verify if chemoresistive sensors can detect variations as a whole technology, or if only some particular semiconductors can be used for screening/detection purposes, and to visualize possible correlations between their response behaviors. Further details in the sensors' functioning, the differences between the various semiconductor materials, and their characterizations can be found in literature [1][2][3][4][5][6][7][33][34][35][36][37][38][39][40][41][42][43][44][45]. The responses are standardly defined as the average value between three output voltages measured by the sensor from the same sample, as shown in the following formula [6]:…”

“…Chemoresistive semiconductor sensors, fast responding devices commonly used for pollution and alimentary screening, could be the brand-new choice of sensing units for medical devices aimed at Sensors 2020, 20, 1411 2 of 15 this kind of approach, as multiple studies have proved their usefulness for screening applications on different biological samples [1][2][3][4][5][6][7].…”