Chemoradiotherapy for Squamous Cell Carcinoma of the Anal Canal: A Case Report

Abstract

: A 79-year-old woman presented to our hospital with frequent episodes of hematochezia. Colonoscopy revealed an apparent tumor with central ulceration, and analysis of biopsy specimens confirmed the presence of non-invasive squamous cell carcinoma of the anal canal. No distant metastases were identi ed on enhanced computed tomography CT . The cancer was classi ed as stage II T2N0M0 , and chemoradiotherapy CRT was selected as the rst-line treatment. A continuous intravenous infusion of 5-uorouracil with daily cisplatin was planned on days 1 to 5 of a 4-week cycle. After the rst course, the drug administration was discontinued because the patient experienced diarrhea as an adverse event, and treatment with daily oral titanium silicate-1 TS-1 was initiated. In addition, a total of 65 Gy of radiation was applied to the primary lesion, pelvis, and bilateral groin area. Four weeks after the completion of CRT, colonoscopy showed the disappearance of the tumor and analysis of biopsy specimens con rmed the absence of any viable cancer cells. CT showed no evidence of lymph node metastasis or distant metastases. At 10 months after the completion of CRT, the patient showed no recurrence and with complete response.