Chemoprophylaxis of Experimental Influenza Infections in Eggs

Rh, Green; Af, Rasmussen; Je, Smadel

doi:10.2307/4585846

Cited by 17 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In tissue-cultures all compounds retarded the growth of the viruses of mumps, influenza A, and influenza B. The results with influenza B in eggs confirmed earlier findings of Green, Rasmussen, and Smadel (1946) with Nitroakridin 3582, though Hurst (1948) and Rasmussen and Stokes (1951) detected no effect of this particular nitroacridine on influenzal infections in mice. Thompson (1947) found that in tissuecultures atabrin, proflavine, and 9-aminoacridine (as well as many other miscellaneous substances) reduced or prevented growth of vaccinia virus, while Briody and Stannard (1951) reported that proflavine inhibited growth of influenza B and vaccinia viruses in developing chick-embryos but exerted no effect on influenza A, mumps, or Newcastle disease.…”

supporting

confidence: 83%

The Action of Mepacrine and Trypan Red in a Number of Virus Diseases

Hurst

Peters

Melvin

1952

British Journal of Pharmacology and Chemotherapy

View full text Add to dashboard Cite

supporting

confidence: 83%

The Action of Mepacrine and Trypan Red in a Number of Virus Diseases

Hurst

Peters

Melvin

1952

British Journal of Pharmacology and Chemotherapy

View full text Add to dashboard Cite

“…A number of chemical substances, most notably zinc sulfate, have been shown to induce a state of decreased susceptibility to intranasal inoculation of poliomyelitis virus (14). An acridine compound (i,e., nitroakridin 3582) has been shown to have an inhibiting effect on influenza B virus in embryonated eggs (15). With the exceptions noted, it appears that there is but-little evidence which indicates that the course of a virus infection can be altered significantly, once it has been initiated, by any substance other than specific antibodies against the virus itself.…”

Section: Discussionmentioning

confidence: 93%

The Modifying Effects of Certain Substances of Bacterial Origin on the Course of Infection With Pneumonia Virus of Mice (Pvm)

Horsfall

McCarty

1947

Journal of Experimental Medicine

View full text Add to dashboard Cite

In the course of investigations concerned with problems relative to the pathogenesis of primary atypical pneumonia, a study was undertaken on the effects of inoculating mice with both a virus and a bacterium. The virus employed in these experiments is known as pneumonia virus of mice, and will hereafter be designated PVM. The bacterium used is a non-hemolytic streptococcus, designated streptococcus MG.When the first experiments were carried out, it was considered that either of two possible results might develop; first, that streptococcus MG would have no discernible influence en the course of an infection induced by PVM; or second, that it might, by contributing to the establishment of a complex infection, cause the results to be more severe than those of infections induced by PVM alone. Surprisingly, neither possibility evolved; instead, the inoculation of streptococcus MG in mice which previously had been inoculated with PVM resulted in a distinctly less severe infection.This unexpected finding was investigated in detail. It is the purpose of this paper to present the results of studies on the modifying effect of certain bacterial species upon the course of infection with PVM. It will be shown that a number of bacterial species are capable of causing such an effect and that this modification, in striking degree, is obtained when suitable bacteria are given either some days before or after inoculation with this virus. Evidence is presented which indicates that this modification phenomenon is the result of inhibition of multiplication of PVM in lung tissue infected with the virus. In addition, data are presented which suggest that the substance responsible for modification with respect to this virus may be polysaccharide in nature. MethodsVirus.NPneumonia virus of mice (PVM), strain 15 (1), was used exclusively. It was mainmined by occasional lung passage in albino Swiss mice and stored at -70°C. in a manner identical with that described previously (2).Virus Tilration$.NTitrations of PVM were carried out in groups of albino Swiss mice. Serial decimal dilutions were employed; each dilution was tested in a group of six mice and in each titration at least thirty mice were used. The technique of titrations, as well as the method of calculation of the 50 per cent maximum score end point (M.S£0), was identical with 623

show abstract

“…effective against rickettsial infections in mice and in embryonated eggs (12,30). NA inhibits the proliferation of influenza B virus (13,25), but it is without influence on the multiplication of influenza A virus (18). NA suppresses infections with the organisms of the lymphogranuloma and psittacosis groups in chick embryos and in mice (8, 14, 18), but it is ineffective against certain neurotropic viruses.…”

mentioning

confidence: 99%

Antibacterial Nitroacridine, Nitroakridin 3582: Effects on Bacterial Growth and Macromolecular Biosynthesis In Vivo

1971

View full text Add to dashboard Cite

The antibacterial drug Nitroakridin 3582 inhibited the growth of selected grampositive bacteria more strongly than it inhibited the growth of gram-negative bacilli. Nitroakridin at concentrations of the order of 5 × 10 −5 m induced lysis of Bacillus licheniformis and Micrococcus lysodeikticus . At concentrations less than 10 −4 m , Nitroakridin 3582 reduced the exponential growth rate of Escherichia coli C-2; at 10 −4 m the drug was bacteriostatic, and, at concentrations greater than 10 −4 m , it was bactericidal. Prolonged bacteriostasis resulted in the formation of long filaments by E. coli, Serratia marcescens, Shigella sonnei , and Proteus mirabilis . The reversible effects of Nitroakridin 3582 on the growth of E. coli correlated with partial inhibitions of deoxyribonucleic acid biosynthesis; ribonucleic acid and protein syntheses were inhibited less strongly. Nitroakridin 3582 at concentrations greater than 2 × 10 −4 m , which block deoxyribonucleic acid biosynthesis, produced an accelerated bactericidal action.

show abstract

Chemoprophylaxis of Experimental Influenza Infections in Eggs

Cited by 17 publications

References 0 publications

The Action of Mepacrine and Trypan Red in a Number of Virus Diseases

The Action of Mepacrine and Trypan Red in a Number of Virus Diseases

The Modifying Effects of Certain Substances of Bacterial Origin on the Course of Infection With Pneumonia Virus of Mice (Pvm)

Antibacterial Nitroacridine, Nitroakridin 3582: Effects on Bacterial Growth and Macromolecular Biosynthesis In Vivo

Contact Info

Product

Resources

About