Chemoprophylactic activity of imidocarb, diminazene and oxytetracycline againts Babesia bovis and B. Bigemina

Kuttler, Kenneth; Johnson, LeRoy

doi:10.1016/0304-4017(86)90151-2

Cited by 30 publications

(17 citation statements)

References 6 publications

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“…This situation favors the emergence of areas of endemic instability (Guglielmone 1995, Bock et al 2004. No characteristic clinical signs of babesiosis and/or anaplasmosis were observed while visiting the farms included in this study, what may be a consequence of widespread treatment of affected cattle adopted by farmers in this region (Kuttler & Johnson 1996, Kocan et al 2010). …”

Section: Discussionmentioning

confidence: 99%

Babesiosis and anaplasmosis in dairy cattle in Northeastern Brazil

et al. 2013

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Pesq. Vet. Bras. 33(9) The goal of this study was to characterize the epidemiological situation and the factors involved in the prevalence of babesiosis and anaplasmosis in cattle in the dairy basin of Parnaíba, Piauí, Brazil. The study was conducted in 22 farms, and collected blood samples from 202 cattle to study serological, molecular and determination of the packed cell volume (PCV). On the farms were applied surveys involving epidemiological aspects. Seroprevalence rates were: Babesia bigemina 52.5%, B. bovis 68.8%, and Anaplasma marginale 89.1%. Of the samples analyzed, 73.3% were reactive for Babesia spp. and A. marginale, showing co-infection. In PCR, B. bigemina and B. bovis were positive in 52.0% and 33.2% respectively, and A. marginale in 76.2%. Of these, 51.5% amplified DNA of Babesia spp. and A. marginale. The semi-intensive management predominated in 68.0% of the farms studied. The clinical history of babesiosis and anaplasmosis, was reported from 73% of the farms. There was no significant difference (p>0.05) between age groups and for the PCV of positive compared with negative animals. The study indicates that in this region is enzootic instability for babesiosis and enzootic stability for anaplasmosis, reinforcing the fact that in Brazil there are areas of enzootic instability, even in tropical regions of the country. The PCR technique was a valuable tool for the diagnosis of these diseases and may be used to characterize a geographic region. ões tropicais do país. A técnica de PCR demonstrou ser uma ferramenta valiosa para o diagnóstico destas doenças e pode ser utilizada para caracterizar uma região geográfica.

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Section: Discussionmentioning

confidence: 99%

Babesiosis and anaplasmosis in dairy cattle in Northeastern Brazil

et al. 2013

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“…As subdoses quimioterápicas permitirão ao animal adquirir a infecção sem sinais clínicos ou com sinais brandos. Para a babesiose, tem-se empregado o imidocarb na dosagem de 1-2mg/kg/PV, com resultados satisfatórios (KUTTLER & JOHNSON, 1986), nos bezerros ao serem colocados a pasto. Esse procedimento evita a presença do agente no organismo ou mantém sua população em níveis subclínicos, estabelecendo o estado de portador ao animal.…”

Section: Controleunclassified

Epidemiologia e controle da tristeza parasitária bovina na região sudeste do Brasil

Gonçalves

2000

Cienc. Rural

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“…Chemotherapy treatments based on diminazene aceturate and imidocarb dipropionate are the most effective and rst-choice methods to manage animals with acute BB and EP [6,7]. However, the e cacy of these drugs is highly variable and treated animals need to be monitored closely for adverse effects, especially when high doses are used for attempting clearance of the parasites, which is a usual occurrence for valuable horses affected by EP [8].…”

Section: Introductionmentioning

confidence: 99%

Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi

Suárez

Silva

Bastos

et al. 2020

Preprint

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Background: The most common apicomplexan parasites causing bovine babesiosis are Babesia bovis and B. bigemina, while B. caballi and Theileria equi are responsible for equine piroplasmosis. Treatment and control of these diseases are usually achieved using potentially toxic chemotherapeutics, such as imidocarb diproprionate, but drug-resistant parasites are emerging, and alternative effective and safer drugs are needed. Endochin-like quinolones (ELQ)-300 and ELQ-316 proved safe and efficacious against related apicomplexans, such as Plasmodium spp., and ELQ-316 was also effective against B. microti, without showing toxicity in mammals.Methods: Inhibitory effects of ELQ-300 and ELQ-316 were assessed on the growth of cultured B. bovis, B. bigemina, B. caballi and T. equi. Percentage of parasitized erythrocytes was measured by flow cytometry. Effect of the ELQ drugs on the viability of actively replicating horse and bovine peripheral blood mononuclear cells (PBMC) was assessed by ELISA. Results: We calculated IC50 ranging from 0.04 to 0.37 nM for ELQ-300, and from 0.002 to 0.1 nM for ELQ-316 at 72 hr among all cultured parasites tested. None of the parasites tested were able to replicate in cultures in the presence of the ELQs-300 and ELQ-316 at IC100, which range from 1.3 to 5.7 nM for ELQ-300 and from 1.0 to 6.0 nM for ELQ-316 at 72 hours. Neither ELQ-300 nor ELQ-316 altered the viability of equine and bovine PBMC at their IC100 in in vitro testing. Conclusions: ELQ-300 and ELQ-316 have a significant inhibitory activity on the main parasites responsible for bovine babesiosis and equine piroplasmosis at doses that are tolerable to host cells. These ELQ drugs may be viable candidates for developing alternative protocols for the treatment of bovine babesiosis and equine piroplasmosis.

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Chemoprophylactic activity of imidocarb, diminazene and oxytetracycline againts Babesia bovis and B. Bigemina

Cited by 30 publications

References 6 publications

Babesiosis and anaplasmosis in dairy cattle in Northeastern Brazil

Babesiosis and anaplasmosis in dairy cattle in Northeastern Brazil

Epidemiologia e controle da tristeza parasitária bovina na região sudeste do Brasil

Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi

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