Chemopreventive Task of Capsaicin against Benzo(a)pyrene‐induced Lung Cancer in Swiss Albino Mice

Abstract

A voluminous number of evidence suggests that an increased consumption of fruits and vegetables is a relatively easy and practical strategy to reduce significantly the incidence of cancer. The present study is an effort to identify the chemopreventive role of alkaloid capsaicin against benzo(a)pyrene-induced lung cancer in Swiss albino mice. Benzo(a)pyrene-induced lung cancer-bearing animals showed abnormal changes in body weight, lung weight, tumour incidence and alterations in the activities of marker enzymes adenosine deaminase, aryl hydrocarbon hydroxylase, γ -glutamyl transpeptidase, 5 ′ -nucleotidase and lactate dehydrogenase. On capsaicin pre-co-treatment, all the above alterations were returned to near normal. Immunohistochemical analysis of proliferating cell nuclear antigen together with lung histological examination further supported our biochemical findings that demonstrated the chemoprotective role of capsaicin against benzo(a)pyrene-induced experimental lung cancer.

Anticancer effect of Limonin against benzo(a)pyrene‐induced lung carcinogenesis in Swiss albino mice and the inhibition of A549 cell proliferation through apoptotic pathway

“…5′‐NTs is an enzyme that hydrolyzes nucleotides through a phosphate group on carbon atom 5 of ribos . In the current study, an elevated level of all the above serum marker enzymes was observed in cancer‐bearing mice and the previous study also reported the same results . Treatment with limonin reverted back the levels of these serum marker enzymes to near to normal, which is suggestive of its anticancer potential.…”

“…Though, the toxic side effects formed by some of these drugs have limited their extensive usage. Therefore, the present study is required to find out the natural compounds that have important anticancer potential without unwanted toxic effects …”

Dual effect of Algerian propolis on lung cancer: antitumor and chemopreventive effects involving antioxidant activity

“…Several epidemiological studies have shown that exposure to polycyclic aromatic hydrocarbons (PAHs) can increase the risk of multiple cancers, such as those of the lung. One of these PAHs is benzo(a)pyrene (B(a) P), which has been widely studied because of its ability to induce carcinogenicity and mutagenicity in humans and animals (Anandakumar et al, 2009;Kasala et al, 2015). However, it must be metabolically activated to the B(a)P-7,8-dihydrodiol-9,10-epoxide metabolite (BPDE) before exerting its toxic effects.…”

Anticancer potential of Tinospora cordifolia and arabinogalactan against benzo(a)pyrene induced pulmonary tumorigenesis: a study in relevance to various biomarkers

“…The considerable weight loss observed in tumor bearing mice could be related to cancer cachexia, anorexia or malabsorption, which resulted in wasting of skeletal muscle and adipose tissue (42). Several studies have shown similar observations of decrease in body weight of animals following administration of B(a) P (43). However, Aq.Tc and AG seem to prevent this alteration in body weight of lung tumor bearing mice.…”