Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout

Dashwood, Roderick H.; Negishi, Tomoe; Hayatsu, Hikoya; Breinholt, Vibeke; Hendricks, Jerry D.; Bailey, George S.

doi:10.1016/s0027-5107(97)00259-5

Cited by 121 publications

(77 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many reports have suggested that medicinal plants, and phytocompound-derived chemical substances are effective in the treatment of diabetes [5,6]; produce less or no side effects.Chlorophyllin is a sodium-copper salt of chlorophyll molecule and water-soluble unlike its parent compound. CHL possess therapeutic importance due to its antimutagenic and anticarcinogenic [7], antioxidative [8], and antihyperglycemic effects DOI:10.5138/09750185.1946…”

Section: Introductionmentioning

confidence: 99%

“…Many have suggested that medicinal plants,phytocompounds, derived chemical substances are effective in the treatment of diabetes [5,6]; produce less or no side copper salt of chlorophyll unlike its parent compound. CHL possess therapeutic importance due to its antimutagenic and anticarcinogenic [7], antioxidative [8], and antihyperglycemic effects [9] in different experimental systems. However, the effect of CHL on oxidative stress in the context study has been carried out to evaluate the effect of CHL on oxidative stress in STZ-induced diabetic mice.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ameliorative Effect of Chlorophyllin on Oxidative Stress in Experimental Model of Diabetes

Patar¹,

Bhan²,

Syiem³

et al. 2017

ijpm

View full text Add to dashboard Cite

The aim of this present study was to investigate the effect of chlorophyllin (CHL) on oxidative stress in Streptozotocine (STZ) induced diabetic mice. For the study, mice were divided into Group A: normal control, Group B: diabetic control, Group C: diabetic mice treated with the ascorbic acid, and Group D: diabetic mice treated with CHL. Levels of Reactive Oxygen Species (ROS), lipid peroxidation, protein carbonyl, superoxide dismutase (CuZn SOD &Mn-SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities were examined in kidney and heart tissues of different experimental groups. Histological and ultrastructuralstudies were also carried out to evaluate any changes in tissues as well as sub-cellular organelles. ROS, lipid peroxidation, and protein carbonyl levels have been significantly decreased with concomitant increased of CuZn SOD, Mn-SOD, CAT, GPx, and GR activity in CHLtreated diabetic mice. The histological and ultrastructural studies showed that CHL attenuates the detrimental effect of oxidative stress and alleviated tissue injuries in STZ induced diabetic mice. These results suggested that CHL possesses antioxidative activity and has the potential to amelioratediabetes-associated oxidative stress in mice.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ameliorative Effect of Chlorophyllin on Oxidative Stress in Experimental Model of Diabetes

Patar¹,

Bhan²,

Syiem³

et al. 2017

ijpm

View full text Add to dashboard Cite

show abstract

“…Anti-mutagenic activity of CHL was demonstrated with respect to heterocyclic amines [1][2][3], benzo[a]pyrene [4,5], aflatoxin [6][7][8][9][10], heavy metals [11], and ionizing radiation [12]. Diversity of the agents whose antimutagenic activity was neutralized by CHL points out that different protective mechanisms may be involved.…”

Section: Introductionmentioning

confidence: 99%

The “interceptor” properties of chlorophyllin measured within the three-component system: Intercalator–DNA–chlorophyllin

Pietrzak

Wieczorek

et al. 2006

Biophysical Chemistry

View full text Add to dashboard Cite

In aqueous solutions, in the presence of double-stranded DNA, chlorophyllin (CHL) forms complexes with each of the three DNA intercalators: acridine orange (AO), quinacrine mustard (QM), and doxorubicin (DOX). The evidence for these interactions was obtained by measurement changes in the absorption and fluorescence spectra of the mixtures containing DNA and intercalators during titration with CHL. A model of simple competition between DNA and CHL for the intercalator was used to define the measured interactions. The concentrations of the complexes estimated based on this model were consistent with the concentrations obtained by actual measurement of the absorption spectra.The present data provide further support for the role of chlorophyllin as an "interceptor" that may neutralize biological activity of aromatic compounds including mutagens and antitumor drugs.

show abstract

“…Because of anti-mutagenic and anti-oxidant properties both chlorophyll and CHL are in center of interest of many research laboratories. Several studies reported that CHL protects cells against mutagenic effects of benzo[a]pyrene [1][2][3][4], cyclophosphamide [3], heterocyclic amines [5][6][7], aflatoxin [8][9][10][11][12], heavy metals [13], and ionizing radiation [14]. Because of diversity of the mutagens neutralized by CHL and different modes of their genotoxicity it is quite apparent that more than a single mechanism may be responsible for the CHL-protective effects.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of acridine mutagen ICR-191 — DNA interactions and DNA damage by the mutagen interceptor chlorophyllin

Pietrzak

Halicka

Wieczorek

et al. 2008

Biophysical Chemistry

View full text Add to dashboard Cite

We have investigated the ability of chlorophyllin (CHL) to interact with acridine mutagen ICR-191 (2-methoxy-6-chloro-9-(3-(2-chloroethyl)aminopropylamino)acridine) and also its ability to decrease binding of ICR-191 to DNA in a simple three-component competition system: CHL-ICR-DNA. Our data indicate a strong association of ICR-191 with CHL, stronger even than the association of ICR-191 with DNA. Calculations based on the measured affinity data show that a two-to threefold excess of CHL reduces by about two-fold the concentration of the mutagen-DNA complex. We also exposed human leukemic HL-60 cells to ICR-191 in the absence and presence of CHL and measured the mutagen-induced DNA damage. The extent of DNA damage was assessed by analysis of histone H2AX phosphorylation. While ICR-191 induced significant increase in expression of phosphorylated H2AX (γH2AX), particularly in DNA replicating cells, this increase was totally abolished in the cells treated with ICR-191 in the presence of CHL.

show abstract

Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout

Cited by 121 publications

References 20 publications

Ameliorative Effect of Chlorophyllin on Oxidative Stress in Experimental Model of Diabetes

Ameliorative Effect of Chlorophyllin on Oxidative Stress in Experimental Model of Diabetes

The “interceptor” properties of chlorophyllin measured within the three-component system: Intercalator–DNA–chlorophyllin

Attenuation of acridine mutagen ICR-191 — DNA interactions and DNA damage by the mutagen interceptor chlorophyllin

Contact Info

Product

Resources

About