Chemopreventive potential of neem (Azadirachta indica) on 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis

Balasenthil, Seetharaman; Arivazhagan, S.; Ramachandran, C. R.; Ramachandran, V.; Nagini, Siddavaram

doi:10.1016/s0378-8741(99)00015-x

Cited by 86 publications

(56 citation statements)

References 24 publications

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“…This may cause mechanical removal of plaque and also contains chemotherapeutic agents which removes dental plaque. 8 The presence of fluoride which is having an anticariogenic action inhibits tooth decay, and silica acting as abrasive and preventing accumulation plaque. Neem is rich of astringents and salts like fluoride, chloride, calcium and sulphur.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Neem Extract on Four Microorganisms Responsible for causing Dental Caries viz Streptococcus mutans, Streptococcus salivarius, Streptococcus mitis and Streptococcus sanguis: An in vitro Study

Chava¹,

Manjunath²,

Rajanikanth³

et al. 2012

The Journal of Contemporary Dental Practice

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History and objectives:From the ancient time, neem used to be the traditional medicine for many diseases and was mainly used for cleaning the oral cavity. The incidence of dental caries was less a few decades ago but now the incidence of caries is very aggressive. This might be due to change in dietary habits, life style and more tendency toward processed food. The objective of this study is to find out the truth that if the neem is really efficacious against caries-inducing microorganisms, mainly Streptococcus mutans, Streptococcus salivarius, Streptococcus mitis and Streptococcus sanguis. Materials and methods:The dried neem sticks ground into a coarse powder and weighed into 5, 10 and 50 gm were added to 100 ml of deionized double distilled water. After soaking for 2 days, the water was filtered at 4°C and the fine filtrate was inoculated onto blood agar plates contains individual species of microorganisms and incubated at 37°C for 2 days. Results:At maximum concentrations, neem extract has shown the maximum zone of inhibition on Streptococcus mutans. At less concentration, the efficacy of neem has shown some inhibition of growth for all the four species of microorganisms. Conclusion:Neem chewing provides the maximum benefits. Hence, the use of chewing sticks of neem can be recommended.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of Neem Extract on Four Microorganisms Responsible for causing Dental Caries viz Streptococcus mutans, Streptococcus salivarius, Streptococcus mitis and Streptococcus sanguis: An in vitro Study

Chava¹,

Manjunath²,

Rajanikanth³

et al. 2012

The Journal of Contemporary Dental Practice

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“…3 We have used this model to document the chemopreventive efficacies of several dietary agents and medicinal plants. 7,8 Of late, medicinal plants rich in antioxidant phytochemicals have received growing attention as potential chemopreventive agents. These medicinal plants are recognized to exert their chemopreventive effects by scavenging ROS and detoxifying potent genotoxic carcinogens.…”

Section: Introductionmentioning

confidence: 99%

Ethanolic leaf extract of neem (Azadirachta indica) inhibits buccal pouch carcinogenesis in hamsters

Rajamanickam

Bhuvaneswari

Ramesh

et al. 2005

Cell Biochem. Funct.

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We evaluated the chemopreventive effects of ethanolic neem leaf extract in the initiation and post-initiation phases of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. The frequency of bone marrow micronuclei as well as the concentrations of lipid peroxides, ratio of reduced to oxidized glutathione (GSH/GSSG), and the activities of the GSH-dependent enzymes glutathione peroxidase (GPx) and glutathione-S-transferase (GST) in the buccal pouch, liver and erythrocytes were used as biomarkers of chemoprevention. All the hamsters painted with DMBA alone for 14 weeks developed buccal pouch carcinomas that showed diminished lipid peroxidation and enhanced antioxidant status associated with increased frequencies of bone marrow micronuclei. In the liver and erythrocytes of tumour-bearing animals, enhanced lipid peroxidation was accompanied by compromised antioxidant defences. Administration of ethanolic neem leaf extract effectively suppressed DMBA-induced HBP carcinogenesis as revealed by the absence of tumours in the initiation phase and reduced tumour incidence in the post-initiation phase. In addition, ethanolic neem leaf extract modulated lipid peroxidation and enhanced antioxidant status in the pouch, liver and erythrocytes and reduced the incidence of bone marrow micronuclei. The results of the present study, demonstrate that ethanolic neem leaf extract inhibits the development of DMBA-induced HBP tumours by protecting against oxidative stress.

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“…Neem's anti viral [36], anti fungal [37], anti bacterial [39] and anti carcinogenic activity [38] makes it a potential agent for root canal irrigation. Neem leaf extract is also used to treat dental plaque and gingivitis.…”

Section: Azadirachta Indica (Neem)mentioning

confidence: 99%

Role of herbs in root canal irrigation-A review

Jain¹,

Ranjan²

2014

IOSRJPBS

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Chemopreventive potential of neem (Azadirachta indica) on 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis

Cited by 86 publications

References 24 publications

The Efficacy of Neem Extract on Four Microorganisms Responsible for causing Dental Caries viz Streptococcus mutans, Streptococcus salivarius, Streptococcus mitis and Streptococcus sanguis: An in vitro Study

The Efficacy of Neem Extract on Four Microorganisms Responsible for causing Dental Caries viz Streptococcus mutans, Streptococcus salivarius, Streptococcus mitis and Streptococcus sanguis: An in vitro Study

Ethanolic leaf extract of neem (Azadirachta indica) inhibits buccal pouch carcinogenesis in hamsters

Role of herbs in root canal irrigation-A review

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