Chemopreventive mechanisms of amentoflavone: recent trends and advancements

Tuli, Hardeep Singh; Joshi, Hemant; Vashishth, Kanupriya; Ramniwas, Seema; Varol, Mehmet; Kumar, Manoj; Rani, Isha; Rani, Vibha; Sak, Katrin

doi:10.1007/s00210-023-02416-6

Cited by 8 publications

(4 citation statements)

References 72 publications

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“…Amentoflavone (AMF) is a natural biflavonoid compound isolated from plants such as ginkgo, hinoki, and St. John's wort (Tuli et al, 2023). Its anticancer features have been linked to its ability to induce cell cycle arrest, apoptosis, and autophagy alongside hindering metastasis and angiogenesis via modulating pathways such as the AMPK/mTOR pathway (Xiong et al, 2021), which is implicated in ferroptosis as well (Wang, Li, Wang, Chen, & Goh, 2023;Wang, Li, Wang, Zhu, Liu, et al, 2023;Wang, Lin, Huang, Liu, Chen, et al, 2023;Wang, Liu, Li, Zha, Chen, et al, 2023;Wang, Shen, Lian, Deng, Qu, et al, 2023;Wang, Tan, Zhang, Wu, & Shi, 2023;Wang, Wan, Peng, Zhao, Bai, & Hu, 2023).…”

Section: Amentoflavonementioning

confidence: 99%

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Zhang,

Xie

2024

Phytotherapy Research

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In recent years, heightened interest surrounds the exploration of natural phenols as potential agents for cancer therapy, specifically by inducing ferroptosis, a unique form of regulated cell death characterized by iron‐dependent lipid peroxidation. This review delves into the roles of key natural phenols, flavonoids, phenolic acids, curcumin, and stilbenes, in modulating ferroptosis and their underlying mechanisms. Emphasizing the significance of amino acid, lipid, and iron metabolism, the study elucidates the diverse pathways through which these phenols regulate ferroptosis. Notably, curcumin, a well‐known polyphenol, exhibits multifaceted interactions with cellular components involved in ferroptosis regulation, providing a distinctive therapeutic avenue. Stilbenes, another phenolic class, demonstrate promising potential in influencing lipid metabolism and iron‐dependent processes, contributing to ferroptotic cell death. Understanding the intricate interplay between these natural phenols and ferroptosis not only illuminates complex cellular regulatory networks but also unveils potential avenues for novel cancer therapies. Exploring these compounds as inducers of ferroptosis presents a promising strategy for targeted cancer treatment, capitalizing on the delicate balance between cellular metabolism and regulated cell death mechanisms. This article synthesizes current knowledge, aiming to stimulate further research into the therapeutic potential of natural phenols in the context of ferroptosis‐mediated cancer therapy.

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Section: Amentoflavonementioning

confidence: 99%

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Zhang,

Xie

2024

Phytotherapy Research

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“…Detecting and inhibiting malignant tumor metastasis is a significant challenge that must always be addressed in the modern practice of cancer treatment [70,72]. In order to combat this problem, scientists have found several natural and chemical compounds that inhibit tumor metastasis [73][74][75]. Anti-metastatic agents generally include angiogenesis inhibitors, integrin antagonists, VEGF inhibitors, anti-MMP agents, and receptor tyrosine kinase inhibitors [76,77].…”

Section: Anti-metastatic Effectmentioning

confidence: 99%

The Pharmacological Implications of Flavopiridol: An Updated Overview

Joshi,

Tuli,

Ranjan

et al. 2023

Molecules

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Flavopiridol is a flavone synthesized from the natural product rohitukine, which is derived from an Indian medicinal plant, namely Dysoxylum binectariferum Hiern. A deeper understanding of the biological mechanisms by which such molecules act may allow scientists to develop effective therapeutic strategies against a variety of life-threatening diseases, such as cancer, viruses, fungal infections, parasites, and neurodegenerative diseases. Mechanistic insight of flavopiridol reveals its potential for kinase inhibitory activity of CDKs (cyclin-dependent kinases) and other kinases, leading to the inhibition of various processes, including cell cycle progression, apoptosis, tumor proliferation, angiogenesis, tumor metastasis, and the inflammation process. The synthetic derivatives of flavopiridol have overcome a few demerits of its parent compound. Moreover, these derivatives have much improved CDK-inhibitory activity and therapeutic abilities for treating severe human diseases. It appears that flavopiridol has potential as a candidate for the formulation of an integrated strategy to combat and alleviate human diseases. This review article aims to unravel the potential therapeutic effectiveness of flavopiridol and its possible mechanism of action.

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“…Amentoflavone is involved in anti‐cancer activity by mediating various signalling pathways such as extracellular signal‐regulated kinase (ERK), nuclear factor kappa‐B (NF‐κB), and phosphoinositide 3‐kinase/protein kinase B (PI3K/Akt). 16 , 17 , 18 , 19 , 20 However, no studies exist regarding the effects of Amentoflavone on epithelial‐mesenchymal transition cells in HCC.…”

Section: Introductionmentioning

confidence: 99%

“…Amentoflavone [8‐[5‐(5,7‐dihydroxy‐4‐oxochromen‐2‐yl)‐2‐hydroxyphenyl]‐5,7‐dihydroxy‐2‐(4‐hydroxyphenyl) chromene‐4‐one, AF], a natural biflavonoids isolated from the medicinal plant Selaginella doederleinii Hieron, 15 is also its main active ingredient. Amentoflavone is involved in anti‐cancer activity by mediating various signalling pathways such as extracellular signal‐regulated kinase (ERK), nuclear factor kappa‐B (NF‐κB), and phosphoinositide 3‐kinase/protein kinase B (PI3K/Akt) 16–20 . However, no studies exist regarding the effects of Amentoflavone on epithelial‐mesenchymal transition cells in HCC.…”

Section: Introductionmentioning

confidence: 99%

Amentoflavone reverses epithelial‐mesenchymal transition in hepatocellular carcinoma cells by targeting p53 signalling pathway axis

Jian,

Zhang,

Liu

et al. 2024

J Cellular Molecular Medi

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Epithelial‐mesenchymal transition (EMT) and its reversal process are important potential mechanisms in the development of HCC. Selaginella doederleinii Hieron is widely used in Traditional Chinese Medicine for the treatment of various tumours and Amentoflavone is its main active ingredient. This study investigates the mechanism of action of Amentoflavone on EMT in hepatocellular carcinoma from the perspective of bioinformatics and network pharmacology. Bioinformatics was used to screen Amentoflavone‐regulated EMT genes that are closely related to the prognosis of HCC, and a molecular prediction model was established to assess the prognosis of HCC. The network pharmacology was used to predict the pathway axis regulated by Amentoflavone. Molecular docking of Amentoflavone with corresponding targets was performed. Detection and evaluation of the effects of Amentoflavone on cell proliferation, migration, invasion and apoptosis by CCK‐8 kit, wound healing assay, Transwell assay and annexin V‐FITC/propidium iodide staining. Eventually three core genes were screened, inculding NR1I2, CDK1 and CHEK1. A total of 590 GO enrichment entries were obtained, and five enrichment results were obtained by KEGG pathway analysis. Genes were mainly enriched in the p53 signalling pathway. The outcomes derived from both the wound healing assay and Transwell assay demonstrated significant inhibition of migration and invasion in HCC cells upon exposure to different concentrations of Amentoflavone. The results of Annexin V‐FITC/PI staining assay showed that different concentrations of Amentoflavone induces apoptosis in HCC cells. This study revealed that the mechanism of Amentoflavone reverses EMT in hepatocellular carcinoma, possibly by inhibiting the expression of core genes and blocking the p53 signalling pathway axis to inhibit the migration and invasion of HCC cells.

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Chemopreventive mechanisms of amentoflavone: recent trends and advancements

Cited by 8 publications

References 72 publications

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

The Pharmacological Implications of Flavopiridol: An Updated Overview

Amentoflavone reverses epithelial‐mesenchymal transition in hepatocellular carcinoma cells by targeting p53 signalling pathway axis

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