Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: Phenolic acids, monophenol, polyphenol, and their derivatives

Resveratrol Exerts Differential Effects in Vitro and in Vivo against Ovarian Cancer Cells

“…Review of the recent literature provides a convincing body of evidence demonstrating resveratrol to have numerous antitumor properties including the ability to decrease cell proliferation, induce apoptosis, and inhibit angiogenesis and tumor growth by mediating a variety of cellular pathways (Bishayee, 2009;Athar et al, 2009;Weng & Yen, 2012). These effects have been documented in numerous types of cancer cells from skin, breast, ovary, prostate, gastrointestinal tract and lung (Aggarwal et al, 2004;Kundu & Surh, 2008).…”

“…Although NuTu-19 ovarian cancer cells were shown to be apoptosis resistant, these cells can be induced to undergo apoptosis when tumor-associated cellular mechanisms are stabilized (Feki et al, 2005;Brard et al, 2006). Since resveratrol mediates effects on a range of pathways (Athar et al, 2009;Bishayee, 2009;Weng & Yen, 2012), cellular stabilization and apoptosis was expected. However, regions of ovarian cancer from control and resveratrol-treated animals showed no detectable difference in fluorescence compared to the negative controls, indicating the absence of resveratrol-mediated apoptosis in the NuTu-19 cells in an in vivo condition.…”

“…Apoptosis is induced in various malignant cells by resveratrol through up-regulation of CD95L expression, caspase activation, stabilization of p53, and inhibition of nuclear factor κB activity (Athar et al, 2009;Delmas et al, 2011;Shukla and Singh, 2011). Several pathways are intertwined and influence additional mechanisms involved in cellular invasion and metastasis, such as the regulation of growth factors and matrix metalloproteins (Weng & Yen, 2012). These multiple overlapping mechanisms contribute to the overall impact of resveratrol's effects against precancerous or cancer cells.…”

A comparative study of the antioxidant, antimicrobial, cytotoxic and thrombolytic potential of the fruits and leaves of Spondias dulcis

“…About 2.0 mL of methanol solution of each extract at different concentration (2,4,6,8,10 µg/mL) were mixed with 3.0 mL of DPPH methanol solution (20 µg/mL). After an incubation period of 30 min, the absorbance was measured at 517 nm against methanol as blank by using a UV-visible spectrophotometer.…”

“…Because of their potent pharmacological activity, low toxicity and economic feasibility, investigation of the medicinal properties of plant has been performed [1] . Along with the nutritional value, plants contribute in the protection from free radical deterioration by hindrance of lipid peroxidation via numerous mechanisms including scavenging free radicals [2] , inducing antioxidant enzymes [3] , modulating protein kinase, and lipid kinase signaling pathway [4] , inhibiting cyclooxygenase-2 (COX 2) and matrix metalloproteinases (MMP 2 and MMP 9) enzymatic activity [5,6] , influencing phytoestrogenic and nuclear transcription factor NF-κB [7,8] , inducing cell cycle arrest and phase 1 or phase 2 metabolizing enzymes [9,10] . Oxidative damage done by free radicals causes the pathogenesis of many deadly diseases like cancer, Alzheimer's and diabetes [11] .…”