Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the epstein–barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis

Kapadia, Govind J.; Azuine, Magnus A.; Tokuda, Harukuni; Takasaki, Midori; Mukainaka, Teruo; Konoshima, Takao; Nishino, Hoyoku

doi:10.1006/phrs.2002.0992

Cited by 200 publications

(134 citation statements)

References 37 publications

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“…The above observations are in conflict with the reported information, which indicated that isolated sesame protein had limited solubility in water between pH 6-7and this (according to the investigators) limits its use in certain food formulation (particularly in fluids and beverages) [9] . This conflict between the reported information regarding sesame protein solubility and the relatively high total solids yield in the prepared milk from the primary experiment could be cleared when discussing the relationship between protein solubility and emulsification properties.…”

Section: Discussionmentioning

confidence: 63%

“…For instance, the proteins of serum albumin, gelatin and egg-white proteins show the maximum emulsifying activity and emulsion capacity at their isoelectric pH. However, this may be valid for thick viscous emulsions, while in more dilute emulsions this effect may minimize repulsion between adjacent droplets, facilitate contact and cause flocculation of emulsion droplets and sedimentation [9] . Additionally, the positive interaction between sesame protein, carbohydrates and sesame oil make the system quite different from observation reported on isolated protein.…”

Section: Discussionmentioning

confidence: 99%

“…Decorticated sesame seed have the following composition: 45-63% (averaging about 50%) oil, 19-31% (averaging about 25%) proteins, about 14% carbohydrate and about 3% ash. Sesame is rich in sulfur-containing amino acids and limited in lysine and contains significant amounts of oxalic (2.5%) and phytic acids (5%) [9] . Because oxalic acid is present in the hulls, decortication can remove most of it [19] .…”

Section: Introductionmentioning

confidence: 99%

“…The last property limits the use of sesame proteins in certain food formulation, particularly in fluids and beverages, which indicates the need for modifying the functionality of sesame proteins before it can be used in processing of imitated dairy products. Functional properties reflect the intrinsic physical attributes of the protein as influenced by interactions with food components and the processing treatments [9] . Defatting, Roasting, puffing, pressure-cooking, microwave cooking, germination, fermentation [10] and soaking were used to modify the functional properties of sesame seed and its meal.…”

Section: Introductionmentioning

confidence: 99%

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Development of Vegetable Based Milk from Decorticated Sesame (Sesamum Indicum)

Quasem¹,

Mazahreh²,

Abu-Alruz³

2009

American J. of Applied Sciences

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Problem statement: Decorticated sesame seed can supply us with nutritious, functional and healthy meals with relatively low cost. These properties make sesame a valuable source of protein and other nutrients to be utilized in imitated dairy products, which could be used for infant and adults with lactose intolerance as well as for vegetarian or others who like to eat dairy products free from cholesterol. Additionally, the production of sesame-based dairy products can overcome the problems that limit consumption of soy-based dairy products such as antinutritional factors, flavor and flatulence. The major challenges in developing dairy analogs from plant sources are: unacceptable flavor, low solids yield and low dispersion stability. Approach: The following factors were investigated to increase/optimize the sesame milk yield, dispersion stability and sensory acceptance: pretreatment of sesame seed with simple physical treatments (soaking in water, boiling, pressure cooking, steaming and combination treatments) and heat treatment of sesame milk (pasteurization or sterilization). Results: Heat treatments during all steps of processing proved to be the most important factor in determining the yield and quality of sesame milk. The best treatment was pasteurized sesame milk (75°C for 5 min) with 12% initial sesame seed concentration (previously dried at 170°C for 5 sec) and formulated with the addition of 2% sucrose. Conclusion: The developed procedure for sesame milk production resulted in high yield, excellent dispersion stability and good sensory acceptability.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development of Vegetable Based Milk from Decorticated Sesame (Sesamum Indicum)

Quasem¹,

Mazahreh²,

Abu-Alruz³

2009

American J. of Applied Sciences

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“…The cytotoxic properties of these extracts were examined using brine shrimp lethality assay (Kapadia et al, 2002;Pimenta et al, 2003). The lethal dose required to kill 50 % of brine shrimps population (LD 50 ) was calculated.…”

Section: Biological Assaysmentioning

confidence: 99%

Comparative Study of the Secondary Metabolites of Sponge-derived Aspergillus flavus

Tawfik

Mesbah

Khalifa

et al. 2017

Records of Pharmaceutical and Biomedical Sciences

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The fungal sources of novel metabolites have broadened from saprophytic terrestrial strains to marine habitats and living plants with their endophytes. Specifically, metabolites isolated from species of genus Aspergillus have continually attracted the interest of pharmacologists due to their broad array of biological activities and their structural diversity. Bioassay guided fractionation of the extract of saline culture of marine-derived Aspergillus flavus led to the isolation of eight compounds; kojic acid (1), aflatoxin B1 (2), maculosin1 (3), hexahydro-3-(4-hydroxybenzyl)pyrrolo[1,2-a]pyrazine-1,4-dione (4), cyclopiazonic acid (5), cyclopiazonic acid imine (6), aspergillic acid (7) and hydroxyaspergillic acid (8). Structure elucidation of the compounds was based on dereplication using NMR and MS data. A cultivation-based approach was employed to compare the secondary metabolites diversity associated with A. flavus in eight sea water culture media. The type of medium exhibited a significant difference in the yield and the chemistry of compounds responsible for biological activities of the corresponding extract.

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Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis

Rho

Kim

Kiguchi

et al. 2011

Molecular Carcinogenesis

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Growth factor receptor (GFR) signaling controls epithelial cell growth by responding to various endogenous or exogenous stimuli and subsequently activating downstream signaling pathways including Stat3, PI3K/Akt/mTOR, MAPK, and c-Src. Environmental chemical toxicants and UVB irradiation cause enhanced and prolonged activation of GFR signaling and downstream pathways that contributes to epithelial cancer development including skin cancer. Recent studies, especially those using tissue-specific transgenic mouse models, have demonstrated that GFRs and their downstream signaling pathways contribute to all three stages of epithelial carcinogenesis by regulating a wide variety of biological functions including proliferation, apoptosis, angiogenesis, cell adhesion and migration. Inhibiting these signaling pathways early in the carcinogenic process results in reduced cell proliferation and survival, leading to decreased tumor formation. Collectively, these studies suggest that GFR signaling and subsequent downstream signaling pathways are potential targets for the prevention of epithelial cancers including skin cancer.

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Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the epstein–barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis

Cited by 200 publications

References 37 publications

Development of Vegetable Based Milk from Decorticated Sesame (Sesamum Indicum)

Development of Vegetable Based Milk from Decorticated Sesame (Sesamum Indicum)

Comparative Study of the Secondary Metabolites of Sponge-derived Aspergillus flavus

Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis

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