Chemopreventive effect of Myricetin, a natural occurring compound, on colonic chronic inflammation and inflammation-driven tumorigenesis in mice

Zhang, Mei-Jia; Su, Han; Yan, Jiajie; Li, Na; Song, Zhiyu; Wang, Huai-Jie; Huo, Lianguang; Feng, Wei; Ji, Wansheng; Qu, Xian‐Jun; Qu, Mei-Hua

doi:10.1016/j.biopha.2017.11.018

Cited by 46 publications

(18 citation statements)

References 27 publications

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“…The relative organ weight in each group only the spleen weight of AOM/DSS group was heavier than other groups, due to the DSS cause inflammation in spleen (Perše and Cerar 2012) (Table 1). Table 2 shows that AOM/DSS treatment significantly reduced the colon length, which was also observed in several other studies (Neufert, Becker et al 2007, Chou, Suh et al 2017, Zhang, Su et al 2018. Dietary supplementation with NOB and DMNB restored the colon length (mm) to 78.3 ± 14.3 and 90.6 ± 14.4, and 81.2 ± 10.2 and 101.3 ± 11.4, at 0.01 and 0.025% NOB or DMNB, respectively, compared to 67.4 ± 6.0 in the AOM/DSStreated group.…”

Section: Dmnb Exhibited Higher Activity In Preventing Colonic Tumor Fsupporting

confidence: 85%

5-Demethylnobiletin is more effective than nobiletin in preventing AOM/DSS-induced colorectal carcinogenesis in ICR mice

Wu¹,

Tung²,

Zheng³

et al. 2018

JFB

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Nobiletin and 5-demethylnobiletin as polymethoxyflavone and hydroxy polymethoxyflavone, especially, have been reported to exhibit various beneficial biological activities for human health. In this study, the effects of NOB and 5-demethylnobiletin (DMNB), on azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal carcinogenesis in Institute for Cancer Research (ICR) mice were compared. We found that NOB and DMNB significantly alleviated the weight loss, colon length and reduced colon tumor formation in AOM/DSS-induced colorectal carcinogenesis mice. At the molecular level, our results from western blot and polymerase chain reaction (PCR) analysis showed that 0.025% of NOB and DMNB presented an anti-inflammation property by reducing cyclooxygenase- 2 (COX-2) and interleukin 6 (IL-6) expression. Taken together, these results demonstrate that DMNB had a better chemo-preventive efficacy than NOB in AOM/DSS-induced colorectal carcinogenesis in ICR mice model.

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Section: Dmnb Exhibited Higher Activity In Preventing Colonic Tumor Fsupporting

confidence: 85%

5-Demethylnobiletin is more effective than nobiletin in preventing AOM/DSS-induced colorectal carcinogenesis in ICR mice

Wu¹,

Tung²,

Zheng³

et al. 2018

JFB

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“…Candidate compound screening and putative target prediction for AMP: Four candidate compounds of AMP were obtained from the TCMSP database, including dihydromyricetin, myricetin, quercetin and taxifolin (Figure 2A and Supplementary Table 3). Since recent research studies have demonstrated strong antiinflammatory activities for all the selected compounds[ 16 , 23 - 25 ], which may be crucially involved in the improvement of UC, putative target prediction was subsequently performed to confirm this hypothesis. Given that the comprehensive biological and pharmacological effects of Chinese herbal plants rely upon their complex compounds and multitarget interactions, a compound-target network was built based on massive open-source initiatives and free web-based tools.…”

Section: Resultsmentioning

confidence: 99%

Systems pharmacology approach reveals the antiinflammatory effects of Ampelopsis grossedentata on dextran sodium sulfate-induced colitis

Chen¹,

Zhang²,

Dai³

et al. 2018

WJG

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AIMTo investigate the protective effects of Ampelopsis grossedentata (AMP) on dextran sulfate sodium (DSS)-induced colitis in mice based on systems pharmacology approach.METHODSSystems pharmacology approach was used to predict the active ingredients, candidate targets and the efficacy of AMP on ulcerative colitis (UC) using a holistic process of active compound screening, target fishing, network construction and analysis. A DSS-induced colitis model in C57BL/6 mice (n = 10/group) was constructed and treated with 5-aminosalicylic acid (100 mg/kg/d) and AMP (400 mg/kg/d) to confirm the underlying mechanisms and effects of AMP on UC with western blot analyses, polymerase chain reaction, histological staining and immunohistochemistry.RESULTSThe therapeutic effects of AMP against DSS-induced colitis were determined in the beginning, and the results showed that AMP significantly improved the disease in general observations and histopathology analysis. Subsequent systems pharmacology predicted 89 corresponding targets for the four candidate compounds of AMP, as well as 123 candidate targets of UC, and protein-protein interaction networks were constructed for the interaction of putative targets of AMP against UC. Enrichment analyses on TNF-α and RANKL/RANK, a receptor activator of NF-κB signaling pathways, were then carried out. Experimental validation revealed that inflammation-related signaling pathways were activated in the DSS group, and AMP significantly suppressed DSS-induced high expression of IRAK1, TRAF6, IκB and NF-κB, and inhibited the elevated expression levels of TNF-α, IL-1β, IL-6 and IL-8.CONCLUSIONAMP could exert protective effects on UC via suppressing the IRAK1/TRAF6/NF-κB-mediated inflammatory signaling pathways.

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“…The doses of myricetin chosen in this study were referred to the previous literature. [13,15,25] The results showed that administration of myricetin (80 mg/kg) significantly decreased the DAI and colon shortening in mice with UC. In addition, myricetin (80 mg/kg) alleviated the inflammation in colonic tissue characterized by reduced depletion of goblet cells, decreased crypt architecture destruction, increased crypt density and reduced ulceration.…”

Section: Discussionmentioning

confidence: 97%

“…In the current study, the potential of myricetin to improve immune balance in mice with UC was determined. The doses of myricetin chosen in this study were referred to the previous literature …”

Section: Discussionmentioning

confidence: 99%

Potential of myricetin to restore the immune balance in dextran sulfate sodium-induced acute murine ulcerative colitis

Liu

Song

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Myricetin is a bioactive compound in many edible plants with anti‐inflammatory and anticarcinogenic activity. The current study aimed to determine the protective effects and mechanism of myricetin against ulcerative colitis (UC). Methods Myricetin was orally administered at doses of 40 and 80 mg/kg to C57BL/6 mice with UC induced using dextran sulfate sodium. The disease‐associated index and colon length were determined at the end of the experiment, the proportion of Treg, Th1 and Th17 was analysed by cytometry, and cytokines were detected using ELISA. Key findings Myricetin (80 mg/kg) ameliorated the severity of inflammation in acute UC and significantly improved the condition. Myricetin (80 mg/kg) elevated the levels of IL‐10 and transforming growth factor β. In addition, the proportion of regulatory T cells significantly increased in mice in the myricetin treatment group. Conclusions Taking together, these results suggest that myricetin exhibits significant protective effects against UC and it could be used as a potential treatment for UC.

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Chemopreventive effect of Myricetin, a natural occurring compound, on colonic chronic inflammation and inflammation-driven tumorigenesis in mice

Cited by 46 publications

References 27 publications

5-Demethylnobiletin is more effective than nobiletin in preventing AOM/DSS-induced colorectal carcinogenesis in ICR mice

5-Demethylnobiletin is more effective than nobiletin in preventing AOM/DSS-induced colorectal carcinogenesis in ICR mice

Systems pharmacology approach reveals the antiinflammatory effects of Ampelopsis grossedentata on dextran sodium sulfate-induced colitis

Potential of myricetin to restore the immune balance in dextran sulfate sodium-induced acute murine ulcerative colitis

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