Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines

Araújo, João Pedro; Gonçalves, Pedro; Martel, Fátima

doi:10.1016/j.nutres.2011.01.006

Cited by 292 publications

(166 citation statements)

References 123 publications

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“…Indeed, the antiproliferative effects of the PWGPE were comparable to effects of catechin, epicatechin and gallic acid at similar concentrations to that found in the extract (p > 0.05). Although the precise concentrations of catechin, epicatechin, gallic acid and quercetin varied in the extract (12.2, 6.3, 3.0 and 2.9 mg/g PWGPE, respectively), as reported previously (Araújo et al, 2011), a combination of polyphenols may target overlapping and complementary phases of the carcinogenic process, thus increasing the efficacy and potency of its chemopreventive effects. Previous data support this, with a variety of phenolic compounds previously described as anticancer compounds with respect to colorectal cancer (Araújo et al, 2011;Ramos et al, 2011;Salucci, Stivala, Maiani, Bugianesi, & Vannini, 2002).…”

Section: Effect On Cell Proliferationmentioning

confidence: 66%

“…Several studies have indicated the anti-cancer potential of polyphenolic compounds, and in particular their ability to inhibit the proliferation of cancer cells via their effects on the cell-cycle and/or apoptosis (Lee et al, 2006;Ramos, Rodríguez-Ramiro, Martín, Goya, & Bravo, 2011;Vu et al, 2012), and have suggested their use as novel dietary chemopreventive agents (Araújo, Gonçalves, & Martel, 2011). For example, the antiproliferative effects of polyphenolic extracts from olive oil (Corona et al, 2007), red wine (Gómez-Alonso et al, 2012), tomato (Saunders, 2009), araçá (Medina et al, 2011), raspberry (Coates et al, 2007) and cranberry (Vu et al, 2012) have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of white grape pomace from winemaking as source of bioactive compounds, and its antiproliferative activity

et al. 2015

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a b s t r a c tThe antiproliferative effects of a purified white grape pomace extract (PWGPE), as well as of some phenolic standards on colon cancer cells were examined. The phenolic composition of the PWGPE was determined by rapid resolution liquid chromatography/mass spectrometry (RRLC/MS). The PWGPE had 92.6, 43.3 and 6.01 mg/g of flavanols, flavonols and phenolic acids, respectively and, along with pure catechin, epicatechin, quercetin and gallic acid, they were all found capable of inhibiting cellular proliferation. PWGPE (100 lg/ml) inhibited the proliferation of cells by 52.1% at 48 h, whilst catechin, epicatechin, quercetin and gallic acid (60 lg/ml) inhibited growth by 65.2%, 62.2%, 81.0% and 71.0%, respectively, at 72 h. The PWGPE is an interesting source of phenolic compounds with antiproliferative properties, that could be of interest in the food and pharmaceutical industries.

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Section: Effect On Cell Proliferationmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Assessment of white grape pomace from winemaking as source of bioactive compounds, and its antiproliferative activity

et al. 2015

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“…These widespread flavonoids, commonly found in various foods [5] , exert numerous biochemical and pharmacological activities, such as antioxidant [6] , anti-inflammatory [7] and antitumor activities [8] . However, the pharmacological effects of rutin and its aglycone may differ, suggesting that the presence of the rutinoside moiety is crucial for some of the protective effects of rutin.…”

Section: Introductionmentioning

confidence: 99%

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

et al. 2012

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Aim: To investigate the mechanisms underlying the protective effects of quercetin-rutinoside (rutin) and its aglycone quercetin against CCl 4 -induced liver damage in mice. Methods: BALB/cN mice were intraperitoneally administered rutin (10, 50, and 150 mg/kg) or quercetin (50 mg/kg) once daily for 5 consecutive days, followed by the intraperitoneal injection of CCl 4 in olive oil (2 mL/kg, 10% v/v). The animals were sacrificed 24 h later. Blood was collected for measuring the activities of ALT and AST, and the liver was excised for assessing Cu/Zn superoxide dismutase (SOD) activity, GSH and protein concentrations and also for immunoblotting. Portions of the livers were used for histology and immunohistochemistry. Results: Pretreatment with rutin and, to a lesser extent, with quercetin significantly reduced the activity of plasma transaminases and improved the histological signs of acute liver damage in CCl 4 -intoxicated mice. Quercetin prevented the decrease in Cu/Zn SOD activity in CCl 4 -intoxicated mice more potently than rutin. However, it was less effective in the suppression of nitrotyrosine formation. Quercetin and, to a lesser extent, rutin attenuated the inflammation in the liver by down-regulating the CCl 4 -induced activation of nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α) and cyclooxygenase (COX-2). The expression of inducible nitric oxide synthase (iNOS) was more potently suppressed by rutin than by quercetin. Treatment with both flavonoids significantly increased NF-E2-related factor 2 (Nrf2) and heme oxygenase (HO-1) expression in injured livers, although quercetin was less effective than rutin at an equivalent dose. Quercetin more potently suppressed the expression of transforming growth factor-β1 (TGF-β1) than rutin. Conclusion: Rutin exerts stronger protection against nitrosative stress and hepatocellular damage but has weaker antioxidant and antiinflammatory activities and antifibrotic potential than quercetin, which may be attributed to the presence of a rutinoside moiety in position 3 of the C ring.

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“…Dietary polyphenols are currently receiving considerable attention for their presumed role in the prevention of various degenerative diseases such as cancers and cardiovascular diseases (Araújo et al 2011). The biological activities of rosemary (Rosmarinus officinalis) polyphenols have been investigated by several research groups (Herrero et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Effect of rosemary polyphenols on human colon cancer cells: transcriptomic profiling and functional enrichment analysis

et al. 2012

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In this work, the effect of rosemary extracts rich on polyphenols obtained using pressurized fluids was investigated on the gene expression of human SW480 and HT29 colon cancer cells. The application of transcriptomic profiling and functional enrichment analysis was done via two computational approaches, Ingenuity Pathway Analysis and Gene Set Enrichment Analysis. These two approaches were used for functional enrichment analysis as a previous step for a reliable interpretation of the data obtained from microarray analysis. Reverse transcription quantitative-PCR was used to confirm relative changes in mRNA levels of selected genes from microarrays. The selection of genes was based on their expression change, adjusted p value, and known biological function. According to genome-wide transcriptomics analysis, rosemary polyphenols altered the expression of *4 % of the genes covered by the Affymetrix Human Gene 1.0ST chip in both colon cancer cells. However, only *18 % of the differentially expressed genes were common to both cell lines, indicating markedly different expression profiles in response to the treatment. Differences in induction of G2/ M arrest observed by rosemary polyphenols in the two colon adenocarcinoma cell lines suggest that the extract may be differentially effective against tumors with specific mutational pattern. From our results, it is also concluded that rosemary polyphenols induced a low degree of apoptosis indicating that other multiple signaling pathways may contribute to colon cancer cell death.

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Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines

Cited by 292 publications

References 123 publications

Assessment of white grape pomace from winemaking as source of bioactive compounds, and its antiproliferative activity

Assessment of white grape pomace from winemaking as source of bioactive compounds, and its antiproliferative activity

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

Effect of rosemary polyphenols on human colon cancer cells: transcriptomic profiling and functional enrichment analysis

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