Chemopreventive effect of dietary flavonoid morin on chemically induced rat tongue carcinogenesis

Kawabata,; Kunihiro,; Tanaka, M.; Takuji,; Honjo,; Kakumoto,; Mikio,; Hara,; Akira,; Makita,; Hiroki,; Tatematsu,; Norichika,; Ushida,; Jun, Jun; Tsuda,; Hiroyuki,; Mori, Taketoshi; Hideki,

doi:10.1002/(sici)1097-0215(19991029)83:3<381::aid-ijc14>3.3.co;2-o

Cited by 15 publications

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“…Feeding of bLF significantly elevated the activity of GST in the liver (by "initiation feeding") and tongue (by "initiation feeding" and "post-initiation feeding"), and increased QR activity in the liver (by "initiation feeding" and "post-initiation feeding"). Similar results have been obtained in our previous studies showing that an organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate, 41) a citrus coumarin derivative, auraptene 33) and a flavonoid, morin, 46) inhibit 4-NQO-induced rat tongue tumorigenesis. These enzymatic alterations caused by bLF feeding may contribute to its chemopreventive activity, although other mechanisms, including immunomodulation, 25,26,28,29) by which bLF might inhibit tumor formation should also be considered.…”

Section: Discussionsupporting

confidence: 90%

Chemopreventive Effect of Bovine Lactoferrin on 4‐Nitroquinoline 1‐Oxide‐induced Tongue Carcinogenesis in Male F344 Rats

Tanaka

Kawabata

Kohno

et al. 2000

Japanese Journal of Cancer Research

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The modifying effects of dietary feeding of bovine lactoferrin (bLF) on tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide (4-NQO) were investigated in male F344 rats. The activities of phase II detoxifying enzymes, glutathione S-transferase (GST) and quinone reductase (QR), polyamine content and ornithine decarboxylase (ODC) activity in the tongue were also examined for mechanistic analysis of possible modifying effects of bLF on carcinogenesis. At 7 weeks of age, all animals except those treated with bLF alone and untreated rats were given 20 ppm 4-NQO in drinking water for 8 weeks to induce tongue neoplasms. Starting 7 days before 4-NQO exposure, experimental groups were fed experimental diets containing bLF (0.2% and 2%) for 10 weeks ("initiation feeding"). Starting 1 week after the cessation of exposure to 4-NQO, the other experimental groups given 4-NQO and a basal diet were fed the experimental diets for 22 weeks ("postinitiation feeding"). At week 32, the incidence and multiplicity of tongue neoplasms in the "initiation feeding" groups of 0.2% and 2% bLF and the "post-initiation feeding" group of 0.2% bLF were lower than those of the 4-NQO alone group, but without statistical significance. However, "post-initiation feeding" of 2% bLF caused a significant reduction in the incidence (20% vs. 55%, P = = = =0.02418) and multiplicity (0.25± ± ± ±0.54 vs. 0.70 ± ± ± ±0.71, P< < < <0.05) of tongue squamous cell carcinoma (by 64%, P = = = =0.02418). bLF treatment elevated liver and tongue GST activities and liver QR activity. The "post-initiation feeding" with 2% bLF significantly decreased QR activity, proliferating cell nulcear antigen-positive index and ODC activity in the tongue. In addition, feeding with bLF decreased tongue polyamine content. These results suggest that bLF, when given at the 2% dose level during the post-initiation phase, exerts chemopreventive action against tongue tumorigenesis through modification of cell proliferation activity and/or the activities of detoxifying enzymes.

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Section: Discussionsupporting

confidence: 90%

Chemopreventive Effect of Bovine Lactoferrin on 4‐Nitroquinoline 1‐Oxide‐induced Tongue Carcinogenesis in Male F344 Rats

Tanaka

Kawabata

Kohno

et al. 2000

Japanese Journal of Cancer Research

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“…Morin has been used as food and herbal medicines with no toxicity or side effects and exhibits various biological activities such as antioxidation, antiinflammation, and anticarcinogenesis in both in vivo and in vitro studies (Gupta et al, 2014;Jung et al, 2010). For instance, morin protects myocytes, endothelial cells, hepatocytes, and erythrocytes through antioxidative effect (Al-Numair et al, 2012), prevents neurodegeneration through inhibiting neuro-inflammation (Noor et al, 2012;Ola et al, 2014), and induces apoptosis to prevent carcinogenesis (Kawabata et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Morin Suppresses Astrocyte Activation and Regulates Cytokine Release in Bone Cancer Pain Rat Models

Jiang

Wang

Sun

et al. 2017

Phytotherapy Research

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As inflammatory and immune responses are involved in pathophysiology of debilitating neuropathic pain, reagents that can modulate these two responses may have therapeutic potential. Morin, derived from the moraceae family of plants, benefits inflammation-related diseases, but its antinociceptive effects on cancer pain remain elusive. In the present study, we investigated antinociceptive effects of morin on bone cancer pain using a rat model, where rats were subject to implantation of Walker 256 mammary gland carcinoma cells into the tibia. Morin (5-20 mg/kg) dose-dependently attenuated behavioral hypersensitivities, including mechanical allodynia and free movement pain, which was accompanied by downregulation of astrocyte marker glial fibrillary acidic protein in the spinal cord in cancer-bearing rats. Treatment with morin also induced reduction of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 and upregulation of an antiinflammatory cytokine IL-10. Furthermore, intrathecal injection of AM630 (an antagonist of cannabinoid receptor 2, CB ), but not naloxone (an antagonist of opioid receptors), significantly blocked morin attenuation of behavioral hypersensitivities. Taken together, these results suggest that morin suppresses astrocyte activation and neuro-inflammation induced by bone cancer pain and its antinociceptive effects on bone cancer pain may be associated with activation of CB receptors in the spinal cord. Copyright © 2017 John Wiley & Sons, Ltd.

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“…Oral lesions induced by 4-NQO are morphologically and histopathologically comparable to human lesions (10)(11)(12). Using 4-NQO-induced rat oral carcinogenesis models, naturally-occurring and related synthetic agents and other anti-oxidant/free radical scavengers derived from food have been reported to inhibit oral carcinogenesis (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31).…”

Section: Introductionmentioning

confidence: 99%

Chemopreventive effect of fermented brown rice and rice bran on 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats

Long

Makita²,

Yamashita³

et al. 2007

Oncol Rep

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The preventive effects of the dietary administration of brown rice and rice bran fermented with Aspergillus oryzae (FBRA) on oral carcinogenesis induced by 4-nitroquinoline 1-oxide (4-NQO) were investigated in male F344 rats. At 7 weeks of age, the animals were given 20 ppm 4-NQO in their drinking water for 8 weeks to induce tongue neoplasms. Groups of rats were fed diets containing 5 or 10% FBRA during the initiation or postinitiation phases of the 4-NQO-induced oral carcinogenesis. The other groups consisted of rats fed 10% FBRA or untreated rats. At the termination of the study (week 32), the incidences, multiplicities of tongue lesions (preneoplasms and neoplasms) and the cell proliferation activity estimated by the 5-bromodeoxyuridine (BrdU)-labeling index were compared among the groups. Feeding of 5% FBRA during the initiation phase significantly decreased the incidence (68.2 vs 36.8%; p<0.05) and multiplicity (1.05±0.84 vs 0.37±0.50; p<0.005) of the tongue carcinoma. When feeding of 10% FBRA occurred after the 4-NQO exposure, the multiplicity of tongue carcinoma was also reduced (1.05±0.84 vs 0.52±0.60; p<0.05). In addition, the dietary administration of FBRA at both doses significantly decreased the BrdU-labeling index in the oral squamous epithelium (p<0.05). Although a dose-dependent response was not observed, FBRA is effective in suppressing the development of 4-NQO-induced oral carcinogenesis by its concurrent exposure to the carcinogen. The inhibitory effect could be related to the suppression of the hyperproliferation of cells in the tongue epithelium and the radical scavenging activity of FBRA.

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Chemopreventive effect of dietary flavonoid morin on chemically induced rat tongue carcinogenesis

Cited by 15 publications

References 0 publications

Chemopreventive Effect of Bovine Lactoferrin on 4‐Nitroquinoline 1‐Oxide‐induced Tongue Carcinogenesis in Male F344 Rats

Chemopreventive Effect of Bovine Lactoferrin on 4‐Nitroquinoline 1‐Oxide‐induced Tongue Carcinogenesis in Male F344 Rats

Morin Suppresses Astrocyte Activation and Regulates Cytokine Release in Bone Cancer Pain Rat Models

Chemopreventive effect of fermented brown rice and rice bran on 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats

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