Chemopreventive effect and angiogenic activity of punicalagin isolated from leaves of Lafoensia pacari A. St.-Hil.

Carneiro, Cristiene Costa; Santos, Suzana da Costa; Lino, Ruy de Souza; Bara, Maria Teresa Freitas; Chaibub, Beatriz Abdallah; Reis, Paulo Roberto de Melo; Chaves, Dwight Assis; Silva, Antônio J. R. da; Silva, Luana Santos; Silva, Daniela de Melo e; Chen-Chen, Lee

doi:10.1016/j.taap.2016.08.015

Cited by 33 publications

(23 citation statements)

References 60 publications

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“…It has strong antioxidant, chemopreventive effect and angiogenic activities in addition to its beneficial effects in attention of prostate cancer cell growth, management of diabetes, myocardial ischemia reperfusion injury, and liver toxicity, tissue repairing and wound healing [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective Effect of Punicalagin against Ethanol-Induced Gastric Ulcer: The Possible Underlying Mechanisms

Mohamed¹,

Salahuddin²

2017

Biomark J

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Gastric ulcer is the most digestive disease found in clinical practice. Punicalagin (PCG) found in pomegranate juice has antioxidant and tissue repair properties. Therefore, the aim of this study was to investigate punicalagin's gastroprotective effect against ethanol-induce gastric injury. Four groups of rats; first group served as control, group 2: Treated with absolute ethanol (5 ml/kg, po), group 3: Rats were pre-treated with ranitidine (as a reference drug) (50 mg/kg, po) before ethanol and group 4: Pre-treated with PCG (4 mg/kg, po) before ethanol. Pretreatment with PCG reduced ulcer index and histopathological changes, oxidative stress induced by ethanol while it elevated antioxidant activity. Although, it down regulated Tumor Necrosis Factor (TNF-α) gene expression and mucosal levels of inflammatory cytokines; TNF-α, Interleukin (IL-1β) and Interferon Gamma (IFNγ), it up regulated mucosal level of IL-10. Also, it reduced mucosal Nuclear Factor Kappa B (NFκB) protein expression, mylopeoxidase and caspase 3 activities as well as gene expression of caspase 9 while it elevated antiapoptotic B-Cell Lymphoma 2 (Bcl-2) gene expression, mucosal nitric oxide and mucin content. However, it had negative action on prostaglandin E2 and acid secretions. These findings indicate gastroprotective effects of punicalagin against ethanol induced gastric ulcer through suppression of mucosal oxidative stress and inflammation through NFκB pathway as well cytoprotective defences independent on prostaglandin E2 and acid secretions.

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Section: Introductionmentioning

confidence: 99%

Gastroprotective Effect of Punicalagin against Ethanol-Induced Gastric Ulcer: The Possible Underlying Mechanisms

Mohamed¹,

Salahuddin²

2017

Biomark J

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“…Leaves from L. pacari A. St.-Hil (Lythraceae) were submitted to ultrasound extraction with acetone:water (70:30) and punicalagin was characterized by HPLC/UV and ESI-TOF MS, 1D and 2D NMR spectroscopic evaluations as described by Carneiro et al 1 .…”

Section: Methodsmentioning

confidence: 99%

“…Punicalagin extracted from Lafoensia pacari A. St.-Hil (Lythraceae) is a compound that has medicinal properties 1 . Lafoensia pacari is a plant known in Brazil as dedaleiro ou pacari.…”

Section: Introductionmentioning

confidence: 99%

Antifungal potential of punicalagin against Cryptococcus neoformans species complex

Silva

Zara

Sá

et al. 2018

Rev. Inst. Med. trop. S. Paulo

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This study evaluated the antifungal activity and cytotoxicity profile of the ellagitannin punicalagin, a compound extracted from the L. pacari A. St.-Hil (Lythraceae) leaf, against Cryptococcus neoformans species complex. Minimum inhibitory concentrations (MIC) were checked using the broth microdilution method. Minimum fungicidal concentrations (MFC) and time of death were used to confirm the antifungal activity of the compound. The in vitro cytotoxicity of punicalagin was tested in BALB/c3T3 fibroblasts and A549 human lung cancer cell line, while the hemolytic potential was tested on sheep erythrocytes. The morphological changes induced in yeast strains by the presence of punicalagin were also analyzed. Tested on eight isolates of the C. neoformans complex punicalagin showed MIC of 0.5 to 4.0 μg/mL and MFC> 256 μg/mL. Punicalagin also demonstrated a good growth inhibitory activity in time-kill curves, but it was not able to achieve a statistically significant reduction of fungal growth suggesting a fungistatic effect of the compound. In vitro cytotoxicity studies using the two cell lines showed that punicalagin has low activity on these cells and no activity on sheep erythrocytes. Morphological changes were seen in the yeasts strains studied when treated with punicalagin. Therefore, punicalagin is a potential antifungal for important pathogenic yeasts and presents a low cytotoxicity profile associated with no hemolytic effects.

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“…There are still few studies conducted on the plant's leaves, but an antinociceptive activity has been reported (Guimarães et al 2010). Its stem bark has pyrrogalic tannins, steroids, triterpenoids, and simple phenols such as ellagic acid (Tamashiro Filho et al 2012), and its leaves have phenolic compounds (Sampaio et al 2011) and punicalagin (1) (Carneiro et al 2016). The latter is an ellagitannin that shows biological activities, e.g., antifungal (Silva et al 2018), chemopreventive, antigenotoxic, and angiogenic (Carneiro et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective activity of punicalagin and Lafoensia pacari in mice

Chaibub

Martins

Paula

et al. 2020

Rev. Bras. Farmacogn.

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Lafoensia pacari A. St.-Hil., Lythraceae, is used in Brazilian folk medicine to treat ulcer and gastritis; thus, it is important to conduct research so as to better understand its medicinal properties. The aim of this study was to assess the antisecretory and antiulcerogenic activities of lyophilized aqueous fraction and punicalagin isolated from leaves of L. pacari. Antisecretory gastric acid activity and antiulcerogenic activity were investigated by pyloric ligation-induced and indomethacin-induced gastric lesion models, respectively. Results show that the lyophilized aqueous fraction of L. pacari and punicalagin reduced the volume of gastric secretion, free acidity, and total acidity in mice 4 h after pyloric ligation, as well as the rate of gastric damage following the indomethacin administration model. Reduction percentages varied according to the dose of each treatment and showed statistical difference. This finding indicates that the lyophilized aqueous fraction of L. pacari and punicalagin exert an antiulcerogenic effect due to their acid antisecretory activity.

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Chemopreventive effect and angiogenic activity of punicalagin isolated from leaves of Lafoensia pacari A. St.-Hil.

Cited by 33 publications

References 60 publications

Gastroprotective Effect of Punicalagin against Ethanol-Induced Gastric Ulcer: The Possible Underlying Mechanisms

Gastroprotective Effect of Punicalagin against Ethanol-Induced Gastric Ulcer: The Possible Underlying Mechanisms

Antifungal potential of punicalagin against Cryptococcus neoformans species complex

Gastroprotective activity of punicalagin and Lafoensia pacari in mice

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