Chemopreventive activity of very low dose dietary tannic acid administration in hepatoma bearing C3H male mice

Nepka, Charitini; Sivridis, Efthimios; Antonoglou, O.; Kortsaris, A.; Georgellis, Antonis; Taitzoglou, Ioannis; Hytiroglou, Prodromos; Papadimitriou, Constantine S.; Zintzaras, Ilias; Kouretas, Demetrios

doi:10.1016/s0304-3835(99)00145-7

Cited by 45 publications

(33 citation statements)

References 18 publications

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“…Polyphenols, which are among the most common naturally occurring anti-oxidants in fruits and vegetables, have been proposed as primary chemopreventive agents; several of these chemopreventive agents are suggested to confer protection against a wide range of cancers including colon cancer (Rajamanickam and Agarwal, 2008;Kang et al, 2011). Tannic acid is reported to be effective against various chemically induced toxicities and also carcinogenesis (Athar et al, 1989;Gali et al, 1992;Horikawa et al, 1994;Nepka et al, 1999;Chen and Chung, 2000;Ferguson, 2001;Ahmad et al, 2011;Ahmad and Sultana, 2012). In present study we showed that pretreatment as well as post treatment with TA resulted in the protection against DMH-induced colon toxicity by amelioration of oxidative stress and inflammatory damage.…”

Section: Discussionmentioning

confidence: 99%

Amelioration of 1,2 Dimethylhydrazine (DMH) Induced Colon Oxidative Stress, Inflammation and Tumor Promotion Response by Tannic Acid in Wistar Rats

Hamiza¹,

Rehman²,

Tahir³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Colon cancer is the third most common malignant neoplasm in the world and it remains an important cause of death, especially in western countries. The toxic environmental pollutant, 1, 2-dimethylhydrazine (DMH), is also a colon-specific carcinogen. Tannic acid (TA) is reported to be effective against various types of chemically induced toxicity and also carcinogenesis. In the present study, we evaluated the chemopreventive efficacy of TA against DMH induced colon toxicity in a rat model. Efficacy of TA against the colon toxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities, lipid peroxidation, histopathological changes and expression of early molecular markers of inflammation and tumor promotion. DMH treatment induced oxidative stress enzymes (p<0.001) and an early inflammatory and tumor promotion response in the colons of Wistar rats. TA treatment prevented deteriorative effects induced by DMH through a protective mechanism that involved reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression levels and TNF-α (p<0.001) release. It could be concluded from our results that TA markedly protects against chemically induced colon toxicity and acts plausibly by virtue of its antioxidant, anti-inflammatory and antiproliferative activities.

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Section: Discussionmentioning

confidence: 99%

Amelioration of 1,2 Dimethylhydrazine (DMH) Induced Colon Oxidative Stress, Inflammation and Tumor Promotion Response by Tannic Acid in Wistar Rats

Hamiza¹,

Rehman²,

Tahir³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Chemoprevention against hepatocellular carcinoma in mouse models has previously been achieved with antioxidants, including vitamin E (10), tannic acid (13), and some selenium compounds (11,12). In most cases, the chemopreventive agent was supplemented during several months, but in some models, a short prenatal and postnatal exposure resulted in significant decrease of hepatocellular carcinoma incidence (11).…”

Section: Discussionmentioning

confidence: 99%

“…To test the effect of inflammation at early age on liver tumor development at the later ages in this hepatocellular carcinoma model, we treated Mdr2-KO mice with chemopreventive agents during first 3 months of their life, the period of maximal inflammation. Doses were selected based on successful chemoprevention experiments on other mouse cancer models (11,13,38).…”

Section: Discussionmentioning

confidence: 99%

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Molecular mechanisms of the chemopreventive effect on hepatocellular carcinoma development in Mdr2 knockout mice

Katzenellenbogen¹,

Mizrahi²,

Pappo

et al. 2007

Molecular Cancer Therapeutics

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Dietary antioxidants and selenium compounds were shown to have a therapeutic effect against hepatocellular carcinoma in several mouse models. We tested the effects of tannic acid and selenomethionine on hepatocellular carcinoma development in Mdr2 knockout (Mdr2-KO) mice. Mdr2-KO and age-matched Mdr2 heterozygous control mice were fed with tannic acid or selenomethionine during the first 3 months of life. Then, several mice from each group were sacrificed, and liver tissue samples were removed for analysis. The remaining mice were fed a regular diet until the age of 16 months, at which time the number and size of liver tumors were determined. Liver tissue samples of 3-month-old mice were subjected to gene expression profiling analysis using cDNA macroarrays containing probes for 240 genes that regulate responses to oxidative stress and inflammation or lipid metabolism. Both tannic acid and selenomethionine had partial chemopreventive effect on development of hepatocellular carcinoma in Mdr2-KO mice: they reduced the incidence of large tumor nodules (diameter >1 cm) at age 16 months. Both agents inhibited gene expression and reversed up-regulation of many genes that control inflammation or response to oxidative stress in Mdr2-KO livers at age 3 months. This inhibitory effect on gene expression correlated with the ability of agents to reduce incidence of large tumors: selenomethionine was more active than tannic acid in both aspects. Understanding the molecular mechanism of chemoprevention effect could improve our therapeutic modalities while using these agents. [Mol Cancer Ther 2007;6(4):1283 -91]

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“…Similarly, to many polyphenols, tannic acid was proved to possess antioxidant [27], antimutagenic [28] and anticarcinogenic properties [29]. The antioxidant mechanism of tannic acid is still far from being fully understood; therefore, it requires further investigation.…”

Section: Polyphenolsmentioning

confidence: 99%

<em>Cistus incanus</em> from Strandja Mountain as a Source of Bioactive Antioxidants

Dimcheva¹,

Karsheva²

2017

Preprint

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Abstract:The purpose of the present study is survey of extraction conditions and exploring antioxidant potential of the non-traditional for the Bulgarian ethno-medicine wild herb Cistus incanus widespread in Strandja Mountain. The influence of the extraction time (0-500 min) and solvent composition (0-50% ethanol in water) on the polyphenols, flavanoids yields and on antioxidant capacity of the extracts of leaves, stalks (wood parts) and buds mixture were studied. The antioxidant capacity (AOC) was evaluated by use of scavenging assays of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. Total phenolic and flavonoid contents were quantified using UV-vis spectrometry. Optimal yield of desired components has been obtained with 30% ethanol in water solvent at 390th min extraction time. In addition, the evaluation of the influence of the seasonality (winter and summer Cistus incanus), and of the different areal parts-hard-coated seeds; buds, and mixture of leaves and stalks of the wild plant through the presence of polyphenols, flavanoids and AOC were investigated. Present work revealed the high values of the polyphenols, flavanoids, the high AOC not only in the summer leaves, but also found in the winter leaves, hard-coated seeds, buds and stalks. Based on the obtained results the Cistus incanus from Strandja mountain could be a new excellent source of natural antioxidants in food and pharmaceutical industries.

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Chemopreventive activity of very low dose dietary tannic acid administration in hepatoma bearing C3H male mice

Cited by 45 publications

References 18 publications

Amelioration of 1,2 Dimethylhydrazine (DMH) Induced Colon Oxidative Stress, Inflammation and Tumor Promotion Response by Tannic Acid in Wistar Rats

Amelioration of 1,2 Dimethylhydrazine (DMH) Induced Colon Oxidative Stress, Inflammation and Tumor Promotion Response by Tannic Acid in Wistar Rats

Molecular mechanisms of the chemopreventive effect on hepatocellular carcinoma development in Mdr2 knockout mice

<em>Cistus incanus</em> from Strandja Mountain as a Source of Bioactive Antioxidants

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