Chemoprevention of preneoplastic liver foci development by dietary mushroom Agaricus blazei Murrill in the rat

Pinheiro, Fabriciano; Faria, Rulian Ricardo; Camargo, João Lauro Viana de; Spinardi-Barbisan, Ana Lúcia Tozzi; Eira, Augusto Ferreira da; Barbisan, Luı́s Fernando

doi:10.1016/s0278-6915(03)00171-6

Cited by 48 publications

(41 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antioxidant activities (EC 50 values) of 50% methanolic extracts from mushrooms of four strains of A. bisporus, determined by scavenging of stable DPPH radicals, varied from 1.0 to 3.6 times. 16 In the work of Pinheiro et al 17 the protective influence of Agaricus blazei meal against the potential of diethylnitrosamine for rat liver carcinogenicity also depended on both the strain and the period of mushroom harvest. In the present study, all mushrooms were collected during the first flush at the same development stage and treated within 15 min after harvest.…”

Section: Results and Discussion Antioxidant Properties Of Methanolic mentioning

confidence: 99%

Radical‐scavenging properties of extracts from the white button mushroom, Agaricus bisporus

2008

View full text Add to dashboard Cite

BACKGROUND: Agaricus bisporus is the premier cultivated edible mushroom but is usually considered to be of lesser value nutritionally and medicinally compared with other cultivated mushrooms. The objective of this study was to investigate the radical-scavenging properties of methanolic extracts and the free radical-processing enzyme activities of water extracts from A. bisporus fruit bodies. Analyses were performed on total fruit bodies from three strains and on separated stipe, cap and gills from one strain, all cultivated experimentally under the same conditions.

show abstract

Section: Results and Discussion Antioxidant Properties Of Methanolic mentioning

confidence: 99%

Radical‐scavenging properties of extracts from the white button mushroom, Agaricus bisporus

2008

View full text Add to dashboard Cite

show abstract

“…Substances occurring in the powdered A. blazei meal may stimulate the hepatic detoxifying enzymatic system or the antioxidant free radical scavenging activities 35) . A. blazei fed in dry powdered form to Wister rats at 10% of the diet exhibited significant chemopreventive influence on the promoting phase of the rat chemical hepatocarcinogenesis 36) . Similar antimutagenic effects were reported for diets containing powder of other mushroom Lentinula edodes 37,38) .…”

mentioning

confidence: 95%

Therapy of Myeloma In Vivo Using Marine Phospholipid in Combination with Agaricus blazei Murill as an Immune Respond Activator

Murakawa

Fukunaga

Tanouchi³

et al. 2007

J. Oleo Sci.

View full text Add to dashboard Cite

“…As the immunohistochemical detection of GST-P 7-7-positive PNL was performed in various fragments of all liver lobes reminiscent after partial hepatectomy, our results were presented as number per cm 2 , mean size (mm 2 ) and percentage of liver area occupied by these lesions (% liver area). (Pinheiro et al 2003;Pires et al 2008).…”

Section: Animals and Treatmentsmentioning

confidence: 99%

“…PCNA labeling indices (PCNA LI %) for each animal were estimated by counting the number of immunohistochemically labeled hepatocytes nuclei (S-Phase) per total number of counted hepatocytes (*2,000) in normal or bearing PNL parenchyma (Pinheiro et al 2003;Pires et al 2008). PCNA LI% was also measured in neoplastic lesions diagnosed at week 35.…”

Section: Animals and Treatmentsmentioning

confidence: 99%

Metalloproteinases 2 and -9 activity during promotion and progression stages of rat liver carcinogenesis

et al. 2008

View full text Add to dashboard Cite

Activity of metalloproteinases 2 and 9 (MMP-2 and 9) during promotion and progression of rat liver carcinogenesis was investigated in a modified resistant hepatocyte model. Development of preneoplastic liver lesions positive for glutathione S-transferase 7-7-(GST-P 7-7-positive PNL) and tumors besides hepatocytes positive for proliferating cell nuclear antigen (PCNA) were quantified and compared to MMP-2 and-9 activity using gelatin zymography. Marked increases in GST-P 7-7-positive PNL development, PCNA labeling indices, MMP-2 (pro, intermediate and active forms) and pro-MMP-9 activity were observed after proliferative stimulus induced by 2-acetylaminofluorene (2-AAF) exposure cycles. After 2-AAF withdrawal, increase in MMP-2 activity was detected only in neoplastic mixed lesions, whereas active MMP-9 was increased in both PLN and neoplastic tissues. Our findings suggest that MMP-2 may be associated with proliferative events induced by 2-AAF rather than with selective growth of PNL and that MMP-9 could be associated with progression of PNL and neoplastic mixed lesions.

show abstract

Chemoprevention of preneoplastic liver foci development by dietary mushroom Agaricus blazei Murrill in the rat

Cited by 48 publications

References 34 publications

Radical‐scavenging properties of extracts from the white button mushroom, Agaricus bisporus

Radical‐scavenging properties of extracts from the white button mushroom, Agaricus bisporus

Therapy of Myeloma In Vivo Using Marine Phospholipid in Combination with Agaricus blazei Murill as an Immune Respond Activator

Metalloproteinases 2 and -9 activity during promotion and progression stages of rat liver carcinogenesis

Contact Info

Product

Resources

About